Incidence of Respiratory Virus-Associated Pneumonia in Urban Poor Young Children of Dhaka, Bangladesh, 2009–2011

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Homaira, Nusrat ; Luby, Stephen P. ; Petri, William A. ; Vainionpaa, Raija ; Rahman, Mustafizur ; Hossain, Kamal ; Snider, Cynthia B. ; Rahman, Mahmudur ; Alamgir, A. S. M. ; Zesmin, Farzina ; Alam, Masud ; Gurley, Emily S. ; Zaman, Rashid Uz ; Azim, Tasnim ; Erdman, Dean D. ; Fry, Alicia M. ; Bresee, Joseph ; Widdowson, Marc-Alain ; Haque, Rashidul ; Azziz-Baumgartner, Eduardo
• Description:
  Background
  
  Pneumonia is the leading cause of childhood death in Bangladesh. We conducted a longitudinal study to estimate the incidence of virus-associated pneumonia in children aged <2 years in a low-income urban community in Dhaka, Bangladesh.
  
  Methods
  
  We followed a cohort of children for two years. We collected nasal washes when children presented with respiratory symptoms. Study physicians diagnosed children with cough and age-specific tachypnea and positive lung findings as pneumonia case-patients. We tested respiratory samples for respiratory syncytial virus (RSV), rhinoviruses, human metapneumovirus (HMPV), influenza viruses, human parainfluenza viruses (HPIV 1, 2, 3), and adenoviruses using real-time reverse transcription polymerase chain reaction assays.
  
  Results
  
  Between April 2009–March 2011, we followed 515 children for 730 child-years. We identified a total of 378 pneumonia episodes, 77% of the episodes were associated with a respiratory viral pathogen. The overall incidence of pneumonia associated with a respiratory virus infection was 40/100 child-years. The annual incidence of pneumonia/100 child-years associated with a specific respiratory virus in children aged <2years was 12.5 for RSV, 6 for rhinoviruses, 6 for HMPV, 4 for influenza viruses, 3 for HPIV and 2 for adenoviruses.
  
  Conclusion
  
  Young children in Dhaka are at high risk of childhood pneumonia and the majority of these episodes are associated with viral pathogens. Developing effective low-cost strategies for prevention are a high priority.
  
  
• Subjects:
  Adenoviridae Child Cohort Studies Humans Incidence Infant Infant, Newborn Longitudinal Studies Metapneumovirus Orthomyxoviridae Pneumonia, Viral Poverty Real-Time Polymerase Chain Reaction Respiratory Syncytial Viruses Respiratory Tract Infections Respirovirus Rhinovirus Risk Factors Urban Population

  More +
• Source:
  PLoS One. 2012; 7(2).
• Pubmed ID:
  22384139
• Pubmed Central ID:
  PMC3285198
• Document Type:
  Journal Article
• Funding:
  1U01CI000628-01/CI/NCPDCID CDC HHS/United States ; R01 AI043596/AI/NIAID NIH HHS/United States
• Volume:
  7
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:021e7c53e8b78a4ad350f600d7f3172869b52fda42e3d75c7828dc4cc6e7d97c
• Download URL:
  https://stacks.cdc.gov/view/cdc/8152/cdc_8152_DS1.pdf
• File Type:
  [PDF - 137.36 KB ]