Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

Payne, Daniel C.; Parashar, Umesh D.; Lopman, Benjamin A.

doi:10.1097/MOP.0000000000000166

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Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

2 2015
By Payne, Daniel C. ; Parashar, Umesh D. ; Lopman, Benjamin A.
http://dx.doi.org/10.1097/MOP.0000000000000166
Source: Curr Opin Pediatr. 27(1):105-109

[PDF-107.44 KB]

English

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Details:

Alternative Title:

Curr Opin Pediatr
Personal Author:

Payne, Daniel C. ; Parashar, Umesh D. ; Lopman, Benjamin A.

Payne, Daniel C. ; Parashar, Umesh D. ; Lopman, Benjamin A. Less -
Description:

Purpose of review

We discuss recent advances in the understanding of acquired immunity and susceptibility to the two major pediatric enteric viral pathogens, norovirus and rotavirus.

Recent findings

The prominent decline in severe rotavirus gastroenteritis in areas with mature rotavirus vaccination programmes has correspondingly unmasked the significant burden of disease associated with norovirus gastroenteritis among children. As epidemiologists and vaccinologists set their sights on this next vaccine target, we provide an update on norovirus vaccine development.

Summary

This information can potentially be used to tailor both applied and developmental efforts to public health interventions against these important pediatric enteric viral pathogens.
Subjects:

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Adaptive Immunity Caliciviridae Infections Child Child, Preschool Disease Susceptibility Gastroenteritis Humans Incidence Molecular Epidemiology Norovirus Rotavirus Rotavirus Infections
Keywords:

[+]

Acquired FUT2 Histo-blood Group Antigen Immunity Innate Norovirus Rotavirus Vaccine
Source:

Curr Opin Pediatr. 27(1):105-109
Pubmed ID:

25490691
Pubmed Central ID:

PMC4618547
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/
Volume:

27
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:a925b67ae2eb832afc48cf8dea7ade26eb64dcbdcb324c70990ba7c657c434e0
Download URL:

https://stacks.cdc.gov/view/cdc/35324/cdc_35324_DS1.pdf
File Type:

nihms724408.nxml

xml

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