Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

Payne, Daniel C.; Parashar, Umesh D.; Lopman, Benjamin A.

doi:10.1097/MOP.0000000000000166

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Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

Published Date:

Feb 2015

Publisher's site:

http://dx.doi.org/10.1097/MOP.0000000000000166 New Site Icon

Source:

Curr Opin Pediatr. 27(1):105-109.

[PDF-107.44 KB]

Details:

Personal Authors:

Payne, Daniel C. ; Parashar, Umesh D. ; Lopman, Benjamin A. ;

Keywords:

[+]

Pubmed ID:

25490691

Pubmed Central ID:

PMC4618547

Description:

Purpose of review

We discuss recent advances in the understanding of acquired immunity and susceptibility to the two major pediatric enteric viral pathogens, norovirus and rotavirus.

Recent findings

The prominent decline in severe rotavirus gastroenteritis in areas with mature rotavirus vaccination programmes has correspondingly unmasked the significant burden of disease associated with norovirus gastroenteritis among children. As epidemiologists and vaccinologists set their sights on this next vaccine target, we provide an update on norovirus vaccine development.

Summary

This information can potentially be used to tailor both applied and developmental efforts to public health interventions against these important pediatric enteric viral pathogens.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Supporting Files:

nihms724408.nxml

application/octet-stream

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