Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

Payne, Daniel C.; Parashar, Umesh D.; Lopman, Benjamin A.

doi:10.1097/MOP.0000000000000166

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

Published Date:

Feb 2015

Publisher's site:

http://dx.doi.org/10.1097/MOP.0000000000000166 New Site Icon

Source:

Curr Opin Pediatr. 27(1):105-109.

[PDF-107.44 KB]

Details:

Personal Authors:

Payne, Daniel C. ; Parashar, Umesh D. ; Lopman, Benjamin A. ;

Keywords:

[+]

Pubmed ID:

25490691

Pubmed Central ID:

PMC4618547

Description:

Purpose of review

We discuss recent advances in the understanding of acquired immunity and susceptibility to the two major pediatric enteric viral pathogens, norovirus and rotavirus.

Recent findings

The prominent decline in severe rotavirus gastroenteritis in areas with mature rotavirus vaccination programmes has correspondingly unmasked the significant burden of disease associated with norovirus gastroenteritis among children. As epidemiologists and vaccinologists set their sights on this next vaccine target, we provide an update on norovirus vaccine development.

Summary

This information can potentially be used to tailor both applied and developmental efforts to public health interventions against these important pediatric enteric viral pathogens.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

nihms724408.nxml

application/octet-stream

No Related Documents.

You May Also Like:

The Vast and Varied Global Burden of Norovirus: Prospects for Prevention and Control

Personal Author:

Lopman, Benjamin A.; Steele, Duncan; Kirkwood, Carl D.; Parashar, Umesh D.;

Published:

Apr 26 2016

Source:

PLoS Med. 13(4).

Description:

Globally, norovirus is associated with approximately one-fifth of all diarrhea cases, with similar prevalence in both children and adults, and is estimated to cause over 200,000 deaths annually in developing countries. Norovirus is an important patho...

File Type:

[PDF - 223.28 KB]
Global burden of norovirus and prospects for vaccine development

Personal Author:

Lopman, Benjamin A.

Corporate Author:

Centers for Disease Control and Prevention (U.S.). Bill & Melinda Gates Foundation.. CDC Foundation..

Published:

August 2015

Description:

The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention, or the US Department of Health and Human Services. : This work was funded i...

File Type:

[PDF - 4.17 MB]
Progress on norovirus vaccine research: public health considerations and future directions

Personal Author:

Mattison, Claire P.; Cardemil, Cristina V.; Hall, Aron J.;

Published:

August 27 2018

Source:

Expert Rev Vaccines. 17(9):773-784

Description:

Introduction: : Noroviruses are the leading cause of foodborne illness worldwide, account for approximately one-fifth of acute gastroenteritis (AGE) cases globally, and cause a substantial economic burden. Candidate norovirus vaccines are in developm...

File Type:

[PDF - 330.42 KB]
Norovirus Infection and Disease in an Ecuadorian Birth Cohort: Association of Certain Norovirus Genotypes With Host FUT2 Secretor Status

Personal Author:

Lopman, Ben A.; Trivedi, Tarak; Vicuña, Yosselin; Costantini, Veronica; Collins, Nikail; Gregoricus, Nicole; Parashar, Umesh; Sandoval, Carlos; Broncano, Nely; Vaca, Maritza; Chico, Martha E.; Vinjé, Jan; Cooper, Philip J.;

Published:

Dec 10 2014

Source:

J Infect Dis. 2014; 211(11):1813-1821.

Description:

Although norovirus is the most common cause of gastroenteritis, there are few data on the community incidence of infection/disease or the patterns of acquired immunity or innate resistance to norovirus.|We followed a community-based birth cohort of 1...

File Type:

[PDF - 303.13 KB]
Epidemiologic Association Between FUT2 Secretor Status and Severe Rotavirus Gastroenteritis in Children in the United States

Personal Author:

Payne, Daniel C.; Currier, Rebecca L.; Staat, Mary A.; Sahni, Leila C.; Selvarangan, Rangaraj; Halasa, Natasha B.; Englund, Janet A.; Weinberg, Geoffrey A.; Boom, Julie A.; Szilagyi, Peter G.; Klein, Eileen J.; Chappell, James; Harrison, Christopher J.; Davidson, Barbara S.; Mijatovic-Rustempasic, Slavica; Moffatt, Mary D.; McNeal, Monica; Wikswo, Mary; Bowen, Michael D.; Morrow, Ardythe L.; Parashar, Umesh D.;

Published:

Nov 2015

Source:

JAMA Pediatr. 169(11):1040-1045.

Description:

IMPORTANCE : A genetic polymorphism affecting FUT2 secretor status in approximately one-quarter of humans of European descent affects the expression of histo-blood group antigens on the mucosal epithelia of human respiratory, genitourinary, and diges...

File Type:

[PDF - 157.17 KB]