Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

Payne, Daniel C.; Parashar, Umesh D.; Lopman, Benjamin A.

doi:10.1097/MOP.0000000000000166

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

Published Date:

Feb 2015

Publisher's site:

http://dx.doi.org/10.1097/MOP.0000000000000166 New Site Icon

Source:

Curr Opin Pediatr. 27(1):105-109.

[PDF - 107.44 KB]

Details:

Personal Authors:

Payne, Daniel C. ; Parashar, Umesh D. ; Lopman, Benjamin A. ;

Keywords:

[+]

Pubmed ID:

25490691

Pubmed Central ID:

PMC4618547

Description:

Purpose of review

We discuss recent advances in the understanding of acquired immunity and susceptibility to the two major pediatric enteric viral pathogens, norovirus and rotavirus.

Recent findings

The prominent decline in severe rotavirus gastroenteritis in areas with mature rotavirus vaccination programmes has correspondingly unmasked the significant burden of disease associated with norovirus gastroenteritis among children. As epidemiologists and vaccinologists set their sights on this next vaccine target, we provide an update on norovirus vaccine development.

Summary

This information can potentially be used to tailor both applied and developmental efforts to public health interventions against these important pediatric enteric viral pathogens.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Supporting Files:

nihms724408.nxml

application/octet-stream

No Related Documents.

You May Also Like:

Innate Resistance and Susceptibility to Norovirus Infection

Personal Author:

Nordgren, Johan; Sharma, Sumit; Kambhampati, Anita; Lopman, Ben; Svensson, Lennart;

Published:

Apr 26 2016

Source:

PLoS Pathog. 12(4).

File Type:

[PDF - 666.71 KB]
Norovirus and Gastroenteritis in Hospitalized Children, Italy

Personal Author:

Colomba, Claudia; Saporito, Laura; Giammanco, Giovanni M.; De Grazia, Simona; Ramirez, Stefania; Arista, Serenella; Titone, Lucina;

Published:

Sep 2007

Source:

Emerg Infect Dis. 13(9):1389-1391.

Description:

Noroviruses were detected in 48.4% of 192 children (<3 years of age) hospitalized for gastroenteritis in Palermo, Italy, during 2004; predominant genotypes were GGIIb/Hilversum and GGII.4 Hunter. Of children with viral enteritis, 19.6% had a mixed no...

File Type:

[PDF - 202.09 KB]
Norovirus and Medically Attended Gastroenteritis in U.S. Children

Personal Author:

Payne, Daniel C.; Vinjé, Jan; Szilagyi, Peter G.; Edwards, Kathryn M.; Staat, Mary Allen; Weinberg, Geoffrey A.; Hall, Caroline B.; Chappell, James; Bernstein, David I.; Curns, Aaron T.; Wikswo, Mary; Shirley, S. Hannah; Hall, Aron J.; Lopman, Benjamin; Parashar, Umesh D.;

Published:

Mar 21 2013

Source:

N Engl J Med. 368(12):1121-1130.

Description:

BACKGROUND : Cases of rotavirus-associated acute gastroenteritis have declined since the introduction of rotavirus vaccines, but the burden of norovirus-associated acute gastroenteritis in children remains to be assessed. : METHODS : We conducted act...

File Type:

[PDF - 245.67 KB]
Rotavirus Serotype G9P[8] and Acute Gastroenteritis Outbreak in Children, Northern Australia

Personal Author:

Kirkwood, Carl; Bogdanovic-Sakran, Nada; Barnes, Graeme; Bishop, Ruth;

Published:

Sep 2004

Source:

Emerg Infect Dis. 10(9):1593-1600.

Description:

During 2001, an outbreak of severe acute gastroenteritis swept through Central and northern Australia and caused serious disruption to health services. We tracked and characterized the rotavirus strain implicated in the outbreak. Comparison of the el...

File Type:

[PDF - 167.81 KB]
Duration of Immunity to Norovirus Gastroenteritis

Personal Author:

Simmons, Kirsten; Gambhir, Manoj; Leon, Juan; Lopman, Ben;

Published:

Aug 2013

Source:

Emerg Infect Dis. 19(8):1260-1267.

Description:

The duration of immunity to norovirus (NoV) gastroenteritis has been believed to be from 6 months to 2 years. However, several observations are inconsistent with this short period. To gain better estimates of the duration of immunity to NoV, we devel...

File Type:

[PDF - 481.51 KB]