Developments in understanding acquired immunity and innate susceptibility to norovirus and rotavirus gastroenteritis in children

Details

• Alternative Title:
  Curr Opin Pediatr
• Personal Author:
  Payne, Daniel C. ; Parashar, Umesh D. ; Lopman, Benjamin A.
• Description:
  Purpose of review
  
  We discuss recent advances in the understanding of acquired immunity and susceptibility to the two major pediatric enteric viral pathogens, norovirus and rotavirus.
  
  Recent findings
  
  The prominent decline in severe rotavirus gastroenteritis in areas with mature rotavirus vaccination programmes has correspondingly unmasked the significant burden of disease associated with norovirus gastroenteritis among children. As epidemiologists and vaccinologists set their sights on this next vaccine target, we provide an update on norovirus vaccine development.
  
  Summary
  
  This information can potentially be used to tailor both applied and developmental efforts to public health interventions against these important pediatric enteric viral pathogens.
  
  
• Subjects:
  Adaptive Immunity Caliciviridae Infections Child Child, Preschool Disease Susceptibility Gastroenteritis Humans Incidence Molecular Epidemiology Norovirus Rotavirus Rotavirus Infections

  More +
• Keywords:
  Acquired FUT2 Histo-blood Group Antigen Immunity Innate Norovirus Rotavirus Vaccine
• Source:
  Curr Opin Pediatr. 27(1):105-109
• Pubmed ID:
  25490691
• Pubmed Central ID:
  PMC4618547
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Volume:
  27
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a925b67ae2eb832afc48cf8dea7ade26eb64dcbdcb324c70990ba7c657c434e0
• Download URL:
  https://stacks.cdc.gov/view/cdc/35324/cdc_35324_DS1.pdf
• File Type:
  [PDF - 107.44 KB ]