Arsenic exposure and hepatitis E virus infection during pregnancy

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Heaney, Christopher D. ; Kmush, Brittany ; Navas-Acien, Ana ; Francesconi, Kevin ; Gössler, Walter ; Schulze, Kerry ; Fairweather, DeLisa ; Mehra, Sucheta ; Nelson, Kenrad E. ; Klein, Sabra L. ; Li, Wei ; Ali, Hasmot ; Shaikh, Saijuddin ; Merrill, Rebecca D. ; Wu, Lee ; West, Keith P. ; Christian, Parul ; Labrique, Alain B.
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• Description:
  Background ; Arsenic has immunomodulatory properties and may have the potential to alter susceptibility to infection in humans. ; Objectives ; We aimed to assess the relation of arsenic exposure during pregnancy with immune function and hepatitis E virus (HEV) infection, defined as seroconversion during pregnancy and postpartum. ; Methods ; We assessed IgG seroconversion to HEV between 1st and 3rd trimester (TM) and 3 months postpartum (PP) among 1100 pregnancies in a multiple micronutrient supplementation trial in rural Bangladesh. Forty women seroconverted to HEV and were matched with 40 non-seroconverting women (controls) by age, parity and intervention. We assessed urinary inorganic arsenic plus methylated species (∑As) (µg/L) at 1st and 3rd TM and plasma cytokines (pg/mL) at 1st and 3rd TM and 3 months PP. ; Results ; HEV seroconverters’ urinary ∑As was elevated throughout pregnancy. Non-seroconverters’ urinary ∑As was similar to HEV seroconverters at 1st TM but declined at 3rd TM. The adjusted odds ratio (95% confidence interval) of HEV seroconversion was 2.17 (1.07, 4.39) per interquartile range (IQR) increase in average-pregnancy urinary ∑As. Increased urinary ∑As was associated with increased concentrations of IL-2 during the 1st and 3rd TM and 3 months PP among HEV seroconverters but not non-seroconverters. ; Conclusions ; The relation of urinary arsenic during pregnancy with incident HEV seroconversion and with IL-2 levels among HEV-seroconverting pregnant women suggests arsenic exposure during pregnancy may enhance susceptibility to HEV infection.
• Subjects:
  • Adolescent
  • Adult
  • Antibodies, Viral
  • Arsenic
  • Bangladesh
  • Case-Control Studies
  • Cytokines
  • Disease Susceptibility
  • Environmental Exposure
  • Environmental Pollutants
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• Keywords:
  • Arsenic
  • Immunotoxicity
  • Hepatitis E virus
  • Pregnancy
  • Cytokines
  • Infection
• Source:
  Environ Res. 142:273-280
• Pubmed ID:
  26186135
• Pubmed Central ID:
  PMC4609253
• Document Type:
  Journal Article
• Funding:
  K01 OH010193/OH/NIOSH CDC HHSUnited States/ ; R56 AI068813/AI/NIAID NIH HHSUnited States/ ; R01HL111938/HL/NHLBI NIH HHSUnited States/ ; P30ES003819/ES/NIEHS NIH HHSUnited States/ ; R56 AI068813-01A2/AI/NIAID NIH HHSUnited States/ ; R01ES021367/ES/NIEHS NIH HHSUnited States/ ; R21 ES024414/ES/NIEHS NIH HHSUnited States/ ; 1K01OH010193-01A1/OH/NIOSH CDC HHSUnited States/ ; R01 HL111938/HL/NHLBI NIH HHSUnited States/ ; R01 ES021367/ES/NIEHS NIH HHSUnited States/ ; P30 ES003819/ES/NIEHS NIH HHSUnited States/
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• Volume:
  142
• Download URL:
  https://stacks.cdc.gov/view/cdc/35079/cdc_35079_DS1.pdf
• File Type:
  [PDF - 519.67 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:8c13f01d898e8da8002927bbc2453bae3f153b25dfa843f41cc5bcd310322854a5eda3aec0c23c2aa29e50a87ee31db784c54a9540579d09dcc6dac404ab818b