Arsenic exposure and hepatitis E virus infection during pregnancy

Details

• Alternative Title:
  Environ Res
• Personal Author:
  Heaney, Christopher D. ; Kmush, Brittany ; Navas-Acien, Ana ; Francesconi, Kevin ; Gössler, Walter ; Schulze, Kerry ; Fairweather, DeLisa ; Mehra, Sucheta ; Nelson, Kenrad E. ; Klein, Sabra L. ; Li, Wei ; Ali, Hasmot ; Shaikh, Saijuddin ; Merrill, Rebecca D. ; Wu, Lee ; West, Keith P. ; Christian, Parul ; Labrique, Alain B.
• Description:
  Background
  
  Arsenic has immunomodulatory properties and may have the potential to alter susceptibility to infection in humans.
  
  Objectives
  
  We aimed to assess the relation of arsenic exposure during pregnancy with immune function and hepatitis E virus (HEV) infection, defined as seroconversion during pregnancy and postpartum.
  
  Methods
  
  We assessed IgG seroconversion to HEV between 1st and 3rd trimester (TM) and 3 months postpartum (PP) among 1100 pregnancies in a multiple micronutrient supplementation trial in rural Bangladesh. Forty women seroconverted to HEV and were matched with 40 non-seroconverting women (controls) by age, parity and intervention. We assessed urinary inorganic arsenic plus methylated species (∑As) (µg/L) at 1st and 3rd TM and plasma cytokines (pg/mL) at 1st and 3rd TM and 3 months PP.
  
  Results
  
  HEV seroconverters’ urinary ∑As was elevated throughout pregnancy. Non-seroconverters’ urinary ∑As was similar to HEV seroconverters at 1st TM but declined at 3rd TM. The adjusted odds ratio (95% confidence interval) of HEV seroconversion was 2.17 (1.07, 4.39) per interquartile range (IQR) increase in average-pregnancy urinary ∑As. Increased urinary ∑As was associated with increased concentrations of IL-2 during the 1st and 3rd TM and 3 months PP among HEV seroconverters but not non-seroconverters.
  
  Conclusions
  
  The relation of urinary arsenic during pregnancy with incident HEV seroconversion and with IL-2 levels among HEV-seroconverting pregnant women suggests arsenic exposure during pregnancy may enhance susceptibility to HEV infection.
  
  
• Subjects:
  Adolescent Adult Antibodies, Viral Arsenic Bangladesh Case-Control Studies Cytokines Disease Susceptibility Environmental Exposure Environmental Pollutants Female Hepatitis E Hepatitis E Virus Humans Immunoglobulin G Pregnancy Pregnancy Trimester, First Pregnancy Trimester, Third Seroconversion Young Adult

  More +
• Keywords:
  Immunotoxicity Infection
• Source:
  Environ Res. 142:273-280
• Pubmed ID:
  26186135
• Pubmed Central ID:
  PMC4609253
• Document Type:
  Journal Article
• Funding:
  K01 OH010193/OH/NIOSH CDC HHSUnited States/ ; R56 AI068813/AI/NIAID NIH HHSUnited States/ ; R01HL111938/HL/NHLBI NIH HHSUnited States/ ; P30ES003819/ES/NIEHS NIH HHSUnited States/ ; R56 AI068813-01A2/AI/NIAID NIH HHSUnited States/ ; R01ES021367/ES/NIEHS NIH HHSUnited States/ ; R21 ES024414/ES/NIEHS NIH HHSUnited States/ ; 1K01OH010193-01A1/OH/NIOSH CDC HHSUnited States/ ; R01 HL111938/HL/NHLBI NIH HHSUnited States/ ; R01 ES021367/ES/NIEHS NIH HHSUnited States/ ; P30 ES003819/ES/NIEHS NIH HHSUnited States/
• Volume:
  142
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:8c13f01d898e8da8002927bbc2453bae3f153b25dfa843f41cc5bcd310322854a5eda3aec0c23c2aa29e50a87ee31db784c54a9540579d09dcc6dac404ab818b
• Download URL:
  https://stacks.cdc.gov/view/cdc/35079/cdc_35079_DS1.pdf
• File Type:
  [PDF - 519.67 KB ]