Arsenic exposure and hepatitis E virus infection during pregnancy

Details

• Personal Author:
  Ali H ; Christian P ; Fairweather D ; Francesconi K ; Gössler W ; Heaney CD ; Klein SL ; Kmush B ; Labrique AB ; Li W ; Mehra S ; Merrill RD ; Navas-Acien A ; Nelson KE ; Schulze K ; Shaikh S ; West KP Jr. ; Wu L
• Description:
  BACKGROUND: Arsenic has immunomodulatory properties and may have the potential to alter susceptibility to infection in humans. OBJECTIVES: We aimed to assess the relation of arsenic exposure during pregnancy with immune function and hepatitis E virus (HEV) infection, defined as seroconversion during pregnancy and postpartum. METHODS: We assessed IgG seroconversion to HEV between 1st and 3rd trimester (TM) and 3 months postpartum (PP) among 1100 pregnancies in a multiple micronutrient supplementation trial in rural Bangladesh. Forty women seroconverted to HEV and were matched with 40 non-seroconverting women (controls) by age, parity and intervention. We assessed urinary inorganic arsenic plus methylated species (EAs) (ug/L) at 1st and 3rd TM and plasma cytokines (pg/mL) at 1st and 3rd TM and 3 months PP. RSULTS: EV seroconverters' urinary EAs was elevated throughout pregnancy. Non-seroconverters' urinary EAs was similar to HEV seroconverters at 1st TM but declined at 3rd TM. The adjusted odds ratio (95% confidence interval) of HEV seroconversion was 2.17 (1.07, 4.39) per interquartile range (IQR) increase in average-pregnancy urinary EAs. Increased urinary EAs was associated with increased concentrations of IL-2 during the 1st and 3rd TM and 3 months PP among HEV seroconverters but not non-seroconverters. CONCLUSIONS: The relation of urinary arsenic during pregnancy with incident HEV seroconversion and with IL-2 levels among HEV-seroconverting pregnant women suggests arsenic exposure during pregnancy may enhance susceptibility to HEV infection. [Description provided by NIOSH]
• Subjects:
  Arsenic Communicable Diseases Inorganic Chemicals Occupational Health Pregnancy Risk Assessment Risk Factors Safety Urine Viral Diseases Women

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• Keywords:
  Arsenic-compounds Author Keywords: Arsenic Cytokines Exposure-levels Hepatitis E Virus Humans Immunotoxicity Infection Infection-control Infectious-diseases Risk-factors Urinalysis Viral-diseases Viral-infections

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Michigan ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  273-280
• Volume:
  142
• NIOSHTIC Number:
  nn:20047377
• Citation:
  Environ Res 2015 Oct; 142:273-280
• Contact Point Address:
  Christopher D. Heaney , Department of Environmental Health Sciences and Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room W7033B, 615 North Wolfe Street, Baltimore, MD 21205
• Email:
  cheaney1@jhu.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2016
• Performing Organization:
  Johns Hopkins University, Baltimore, Maryland
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  Environmental Research
• End Date:
  20150630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ef0aec3c5d8a8ffff3a8f7ad63fa00c5ecec05e9f200a1816ffbd20b2e4a722ee1d49226c33ec89a7b3456abf30bd8e656298519abd8425adcb9bf89d66221ed
• Download URL:
  https://stacks.cdc.gov/view/cdc/202461/cdc_202461_DS1.pdf
• File Type:
  [PDF - 399.83 KB ]