Lung Function, Airway Inflammation, and Polycyclic Aromatic Hydrocarbons Exposure in Mexican Schoolchildren

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Barraza-Villarreal, Albino ; Escamilla-Nuñez, Maria Consuelo ; Schilmann, Astrid ; Hernandez-Cadena, Leticia ; Li, Zheng ; Romanoff, Lovisa ; Sjödin, Andreas ; Del Río-Navarro, Blanca Estela ; Díaz-Sanchez, David ; Díaz-Barriga, Fernando ; Sly, Peter ; Romieu, Isabelle
• Description:
  Objective
  
  To determine the association of exposure to polycyclic aromatic hydrocarbons (PAHs) with lung function and pH of exhaled breath condensate (EBC) in Mexican schoolchildren.
  
  Methods
  
  A pilot study was performed in a subsample of 64 schoolchildren from Mexico City. Lung function and pH of EBC were measured and metabolites of PAHs in urine samples were determined. The association was analyzed using robust regression models.
  
  Results
  
  A 10% increase in the concentrations of 2-hydroxyfluorene was significantly negatively associated with forced expiratory volume in 1 second (−11.2 mL, 95% CI: −22.2 to −0.02), forced vital capacity (−11.6 mL, 95% CI: −22.9 to −0.2), and pH of EBC (−0.035, 95% CI: −0.066 to −0.005).
  
  Conclusion
  
  Biomarkers of PAHs exposure were inversely associated with lung function and decrease of ph of EBC as a marker of airway inflammation in Mexican schoolchildren.
  
  
• Subjects:
  Adolescent Biomarkers Child Cross-Sectional Studies Environmental Exposure Female Humans Male Mexico Pilot Projects Polycyclic Aromatic Hydrocarbons Respiratory Function Tests Risk Factors Surveys And Questionnaires

  More +
• Source:
  J Occup Environ Med. 56(4):415-419
• Pubmed ID:
  24500378
• Pubmed Central ID:
  PMC4604599
• Document Type:
  Journal Article
• Funding:
  001/WHO_/World Health OrganizationInternational/ ; CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  56
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:29222251886ec273f44f16dd8d6766b1c927c6f4468452b5700b29ae57e29890
• Download URL:
  https://stacks.cdc.gov/view/cdc/34953/cdc_34953_DS1.pdf
• File Type:
  [PDF - 165.63 KB ]