Biomarkers of exposure to polycyclic aromatic hydrocarbons (PAHs) and DNA damage: a cross-sectional pilot study among roofers in South Florida.

Details

• Personal Author:
  Dou Z ; Lee D ; Serdar B ; Dou Z ; Lee D ; Serdar B
• Description:
  Objective: The main goal of this pilot study was to assess the technical and logistic feasibility of a future study. The research hypothesis is that occupational exposures to polycyclic aromatic hydrocarbons (PAHs) are associated with increased risk of DNA damage among roofers who work with hot asphalt. Design: This is a cross-sectional pilot study. Setting: The study included roofers from four different construction sites in Miami-Dade County, Florida. Participants: 19 roofers were recruited (six Hispanics and 13 African-Americans, all male), all of whom were eligible (no history of cancer and no history of chronic diseases of kidneys or liver). All participants provided pre-shift samples and 18 provided post-shift samples. Samples of one participant were excluded from the final analyses as they were considered unreliable. Results: Levels of urinary PAH metabolites increased during 6 h of work. Linear regression models of post-shift metabolites included their pre-shift levels, post-shift urinary creatinine levels (for models of 1-OHPyr and 9-OHPhe), and skin burn due to contact with hot asphalt (for models of 1-OHPyr and 1-OHNap). Pre-shift levels of urinary 8-OHdG were not associated with any of the variables considered. For post-shift levels of 8-OHdG, however, post-shift 1-OHPyr (95% CI 0.091 to 0.788) and use of protective gloves (95% CI -1.57 to -0.61) during work explained 86.8% of its variation. Overall, highest levels of urinary PAH metabolites and of 8-OHdG were observed among workers who reported having skin burn and who did not use gloves during work. Conclusions: Urinary 1-OHPyr is a promising predictor of oxidative DNA damage among roofers. Work-related skin burn and use of protective gloves appear to influence PAH exposure and DNA damage levels in this group, suggesting the importance of dermal absorption. A correction to this article has been published and can be viewed here: https://doi.org/10.1136/bmjopen-2012-001318Corr1. [Description provided by NIOSH]
• Subjects:
  Biomarkers Construction Industry Hydrocarbons Occupational Exposure Occupational Health Polycyclic Aromatic Hydrocarbons Safety
• Keywords:
  Roofers; Roofing industry; Biomarkers; Cross sectional studies; Polycyclic aromatic hydrocarbons; DNA damage; Asphalt fumes; Occupational exposure
• ISSN:
  2044-6055
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  Colorado ; Florida ; New Jersey ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  2
• Issue:
  4
• NIOSHTIC Number:
  nn:20065289
• Citation:
  BMJ Open 2012 Jul; 2(4):e001318
• Contact Point Address:
  Dr Berrin Serdar, Department of Environmental and Occupational Health, Robert Stempel College of Public Health and Social Work, Florida International University, Aurora, Colorado, USA
• Email:
  berrin.serdar@ucdenver.edu
• Federal Fiscal Year:
  2012
• Performing Organization:
  Sunshine Education and Research Center, University of South Florida
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  BMJ Open
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:88e9b0e275c01801998192d2afb318d16dcbd993268fe4c28f5a8b749101130bb8937bd677dead04270a36ff18325da43ed2011986b614774fabe8ff40b0bcad
• Download URL:
  https://stacks.cdc.gov/view/cdc/248774/cdc_248774_DS1.pdf
• File Type:
  [PDF - 206.72 KB ]