Rifampicin-resistant Mycobacterium tuberculosis: susceptibility to isoniazid and other anti-tuberculosis drugs

Kurbatova, Ekaterina V.; Cavanaugh, J. Sean; Shah, N. Sarita; Wright, Abigail; Kim, HeeJin; Metchock, Beverly; Van Deun, Armand; Barrera, Lucia; Boulahbal, Fadila; Richter, Elvira; Martín-Casabona, Nuria; Arias, Fabiola; Zemanova, Ilona; Drobniewski, Francis; Silva, Anabela Santos; Coulter, Christopher; Lumb, Richard; Cegielski, J. Peter

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CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners. As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.

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Rifampicin-resistant Mycobacterium tuberculosis: susceptibility to isoniazid and other anti-tuberculosis drugs

2012
By Kurbatova, Ekaterina V. ; Cavanaugh, J. Sean ; Shah, N. Sarita ; ...
Source: Int J Tuberc Lung Dis. 16(3):355-357

[PDF-120.90 KB]

English

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Details:

Alternative Title:

Int J Tuberc Lung Dis
Personal Author:

Kurbatova, Ekaterina V. ; Cavanaugh, J. Sean ; Shah, N. Sarita ; Wright, Abigail ; Kim, HeeJin ; ... More +

Kurbatova, Ekaterina V. ; Cavanaugh, J. Sean ; Shah, N. Sarita ; Wright, Abigail ; Kim, HeeJin ; Metchock, Beverly ; Van Deun, Armand ; Barrera, Lucia ; Boulahbal, Fadila ; Richter, Elvira ; Martín-Casabona, Nuria ; Arias, Fabiola ; Zemanova, Ilona ; Drobniewski, Francis ; Silva, Anabela Santos ; Coulter, Christopher ; Lumb, Richard ; Cegielski, J. Peter Less -
Description:

Based on data from 14 Supranational Tuberculosis (TB) Reference Laboratories worldwide, the proportion of rifampicin (RMP) resistant isolates that were isoniazid (INH) susceptible by phenotypic drug susceptibility testing varied widely (0.5-11.6%). RMP-resistant isolates that were INH-susceptible had significantly lower rates of resistance to other first- and second-line anti-tuberculosis drugs (except rifabutin) compared to multidrug-resistant isolates. RMP resistance is not always a good proxy for a presumptive diagnosis of multidrug-resistant TB, which has implications for use of molecular assays that identify only RMP resistance-associated DNA mutations.
Subjects:

[+]

Antitubercular Agents Article DNA Mutational Analysis Drug Resistance Drug Resistance, Bacterial Humans Isoniazid Microbial Sensitivity Tests Molecular Diagnostic Tests Mycobacterium Tuberculosis Retrospective Studies Rifampicin Resistance Rifampin Tuberculosis Tuberculosis, Multidrug-Resistant
Source:

Int J Tuberc Lung Dis. 16(3):355-357
Pubmed ID:

22640449
Pubmed Central ID:

PMC4593496
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Volume:

16
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:929793ca088822139f4d78e5db1028d5549eb31728b37deaa6285d029f556fbf
Download URL:

https://stacks.cdc.gov/view/cdc/34755/cdc_34755_DS1.pdf
File Type:

nihms725518.nxml

xml

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