Evaluation of Fibrogenic Potential of Industrial Multi-Walled Carbon Nanotubes in Acute Aspiration Experiment

Khaliullin, T. O.; Shvedova, A. A.; Kisin, E. R.; Zalyalov, R. R.; Fatkhutdinova, L. M.

doi:10.1007/s10517-015-2835-7

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Evaluation of Fibrogenic Potential of Industrial Multi-Walled Carbon Nanotubes in Acute Aspiration Experiment

Published Date:

Mar 17 2015

Publisher's site:

http://dx.doi.org/10.1007/s10517-015-2835-7 New Site Icon

Source:

Bull Exp Biol Med. 158(5):684-687.

[PDF - 1.10 MB]

Details:

Personal Authors:

Khaliullin, T. O. ; Shvedova, A. A. ; Kisin, E. R. ; Zalyalov, R. R. ; Fatkhutdinova, L. M. ;

Keywords:

[+]

Pubmed ID:

25778660

Pubmed Central ID:

PMC4592486

Description:

Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Supporting Files:

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