Details:

Alternative Title:
Bull Exp Biol Med
Publisher's site:
http://dx.doi.org/10.1007/s10517-015-2835-7
Personal Author:
Khaliullin, T. O. ; Shvedova, A. A. ; Kisin, E. R. ; Zalyalov, R. R. ; Fatkhutdinova, L. M. ;
Khaliullin, T. O. ; Shvedova, A. A. ; Kisin, E. R. ; Zalyalov, R. R. ; Fatkhutdinova, L. M. ; Less -
Description:
Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers.
Subject:
[+]
Article
Bronchoalveolar Lavage
Carbon Nanotubes
Fibrosis
In Vivo

Source:
Bull Exp Biol Med. 158(5):684-687. ;
Pubmed ID:
25778660
Pubmed Central ID:
PMC4592486
Document Type:
Journal Article ;
Funding:
CC999999/Intramural CDC HHS/United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:74f693c458711faa44c94b5c5fda0f8e5179960abbbca1cc619b56f4e3fa0891
File Type:

Supporting Files

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