Evaluation of Fibrogenic Potential of Industrial Multi-Walled Carbon Nanotubes in Acute Aspiration Experiment

Details

• Alternative Title:
  Bull Exp Biol Med
• Personal Author:
  Khaliullin, T. O. ; Shvedova, A. A. ; Kisin, E. R. ; Zalyalov, R. R. ; Fatkhutdinova, L. M.
• Description:
  Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers.
• Subjects:
  Article Bronchoalveolar Lavage Carbon Nanotubes Fibrosis In Vivo
• Source:
  Bull Exp Biol Med. 158(5):684-687.
• Pubmed ID:
  25778660
• Pubmed Central ID:
  PMC4592486
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  158
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:74f693c458711faa44c94b5c5fda0f8e5179960abbbca1cc619b56f4e3fa0891
• Download URL:
  https://stacks.cdc.gov/view/cdc/34680/cdc_34680_DS1.pdf
• File Type:
  [PDF - 1.10 MB ]