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Evaluation of Fibrogenic Potential of Industrial Multi-Walled Carbon Nanotubes in Acute Aspiration Experiment
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Mar 17 2015
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Source: Bull Exp Biol Med. 158(5):684-687.
[PDF-1.10 MB]
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Alternative Title:Bull Exp Biol Med
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Description:Local inflammatory response in the lungs and fi brogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, fl ow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers.
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Pubmed ID:25778660
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Pubmed Central ID:PMC4592486
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Volume:158
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Issue:5
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