Evaluation of fibrogenic potential of industrial multi-walled carbon nanotubes in acute aspiration experiment

Details

• Personal Author:
  Fatkhutdinova LM ; Khaliullin TO ; Kisin ER ; Shvedova AA ; Zalyalov RR
• Description:
  Local inflammatory response in the lungs and fibrogenic potential of multi-walled carbon nanotubes were studied in an acute aspiration experiment in mice. The doses were chosen based on the concentration of nanotubes in the air at a workplace of the company-producer. ELISA, flow cytometry, enhanced darkfield microscopy, and histological examination showed that multi-walled carbon nanotubes induced local inflammation, oxidative stress, and connective tissue growth (fibrosis). Serum levels of TGF-β1 and osteopontin proteins can serve as potential exposure biomarkers. [Description provided by NIOSH]
• Subjects:
  Animals Fibrosis Laboratories Lung Occupational Health Oxidants Respiratory System Safety
• Keywords:
  Author Keywords: Carbon Nanotubes Bronchoalveolar Lavage In Vivo Laboratory-animals Lung-fibrosis Lung-function Lung-irritants Lung-tissue Microscopy Nanotechnology Oxidative-metabolism Proteins

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• ISSN:
  0007-4888
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  158
• Issue:
  5
• NIOSHTIC Number:
  nn:20045976
• Citation:
  Bull Exp Biol Med 2015 Mar; 158(5):684-687
• Email:
  liliya.fatkhutdinova@gmail.com
• Federal Fiscal Year:
  2015
• Peer Reviewed:
  True
• Source Full Name:
  Bulletin of Experimental Biology and Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:db13ff96a94ee25cc1cc9eb1da4d407bf6b049e5c1daf942c9fe5ca908c391fe4d103e44c96a58c8c73abb9702cd39cbcc73e1ab1ea8c3d05aabb4c3a0840e8d
• Download URL:
  https://stacks.cdc.gov/view/cdc/201180/cdc_201180_DS1.pdf
• File Type:
  [PDF - 2.62 MB ]