Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997–2002

Gilboa, SM; Desrosiers, TA; Lawson, CC; Lupo, PJ; Riehle-Colarusso, T; Stewart, PA; van Wijngaarden, E; Waters, MA; Correa, A

doi:10.1136/oemed-2011-100536

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Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997–2002

9 2012
By Gilboa, SM ; Desrosiers, TA ; Lawson, CC ; ...
http://dx.doi.org/10.1136/oemed-2011-100536
Source: Occup Environ Med. 69(9):628-635

[PDF-280.33 KB]

English

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Details:

Alternative Title:

Occup Environ Med
Personal Author:

Gilboa, SM ; Desrosiers, TA ; Lawson, CC ; Lupo, PJ ; Riehle-Colarusso, T ; ... More +

Gilboa, SM ; Desrosiers, TA ; Lawson, CC ; Lupo, PJ ; Riehle-Colarusso, T ; Stewart, PA ; van Wijngaarden, E ; Waters, MA ; Correa, A Less -
Corporate Authors:

National Birth Defects Prevention Study
Description:

Objective

To examine the relation between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents, and Stoddard solvent during the period from one month before conception through the first trimester.

Methods

The study population included mothers of infants with simple, isolated CHDs and mothers of control infants who delivered from 1997 through 2002 and participated in the National Birth Defects Prevention Study. Two methods to assess occupational solvent exposure were employed: an expert consensus-based approach and a literature-based approach. Multiple logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between solvent classes and CHDs.

Results

2,951 control mothers and 2,047 CHD case mothers were included. Using the consensus-based approach, associations were observed for exposure to any solvent and any chlorinated solvent with perimembranous ventricular septal defects (OR 1.6; 95% CI 1.0 to 2.6 and OR 1.7; 95% CI 1.0 to 2.8 respectively). Using the literature-based approach, associations were observed for: any solvent exposure with aortic stenosis (OR 2.1; 95% CI 1.1 to 4.1); and Stoddard solvent exposure with d-transposition of the great arteries (OR 2.0; 95% CI 1.0 to 4.2), right ventricular outflow tract obstruction defects (OR 1.9; 95% CI 1.1 to 3.3), and pulmonary valve stenosis (OR 2.1; 95% CI 1.1 to 3.8).

Conclusions

We found evidence of associations between occupational exposure to solvents and several types of CHDs. These results should be interpreted in light of the potential for misclassification of exposure.
Subjects:

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Adolescent Adult Aortic Valve Stenosis Case-Control Studies Female Heart Defects, Congenital Heart Septal Defects, Ventricular Humans Hydrocarbons Hydrocarbons, Chlorinated Infant, Newborn Logistic Models Maternal Exposure Occupational Exposure Odds Ratio Pregnancy Pregnancy Complications Pulmonary Valve Stenosis Risk Factors Solvents Transposition Of Great Vessels Ventricular Outflow Obstruction Young Adult
Keywords:

[+]

Congenital Heart Defects Occupational Exposure Solvents
Source:

Occup Environ Med. 69(9):628-635
Pubmed ID:

22811060
Pubmed Central ID:

PMC4472304
Document Type:

Journal Article
Funding:

200-2000-08018/PHS HHSUnited States/ ; FOA DD09-001/DD/NCBDD CDC HHSUnited States/ ; PA 02081/PHS HHSUnited States/ ; PA 96043/PHS HHSUnited States/ ; CC999999/Intramural CDC HHSUnited States/

200-2000-08018/PHS HHSUnited States/ ; FOA DD09-001/DD/NCBDD CDC HHSUnited States/ ; PA 02081/PHS HHSUnited States/ ; PA 96043/PHS HHSUnited States/ ; CC999999/Intramural CDC HHSUnited States/ Less -
Volume:

69
Issue:

9
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:d56c605273b95ba1183a1e9fb019702a9f9c609672347eae7ce1339ee91c29bd
Download URL:

https://stacks.cdc.gov/view/cdc/33786/cdc_33786_DS1.pdf
File Type:

	NIHMS699375-supplement-Appendix.docx	docx
	nihms699375.nxml	xml

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