Association between maternal occupational exposure to organic solvents and congenital heart defects, National Birth Defects Prevention Study, 1997–2002
Published Date:Jul 17 2012
Source:Occup Environ Med. 69(9):628-635.
Corporate Authors:National Birth Defects Prevention Study
Aortic Valve Stenosis
Congenital Heart Defects
Heart Defects, Congenital
Heart Septal Defects, Ventricular
Pulmonary Valve Stenosis
Transposition Of Great Vessels
Ventricular Outflow Obstruction
Pubmed Central ID:PMC4472304
Funding:200-2000-08018/PHS HHS/United States
FOA DD09-001/DD/NCBDD CDC HHS/United States
PA 02081/PHS HHS/United States
PA 96043/PHS HHS/United States
SUZ0/Intramural CDC HHS/United States
To examine the relation between congenital heart defects (CHDs) in offspring and estimated maternal occupational exposure to chlorinated solvents, aromatic solvents, and Stoddard solvent during the period from one month before conception through the first trimester.
The study population included mothers of infants with simple, isolated CHDs and mothers of control infants who delivered from 1997 through 2002 and participated in the National Birth Defects Prevention Study. Two methods to assess occupational solvent exposure were employed: an expert consensus-based approach and a literature-based approach. Multiple logistic regression was used to calculate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between solvent classes and CHDs.
2,951 control mothers and 2,047 CHD case mothers were included. Using the consensus-based approach, associations were observed for exposure to any solvent and any chlorinated solvent with perimembranous ventricular septal defects (OR 1.6; 95% CI 1.0 to 2.6 and OR 1.7; 95% CI 1.0 to 2.8 respectively). Using the literature-based approach, associations were observed for: any solvent exposure with aortic stenosis (OR 2.1; 95% CI 1.1 to 4.1); and Stoddard solvent exposure with d-transposition of the great arteries (OR 2.0; 95% CI 1.0 to 4.2), right ventricular outflow tract obstruction defects (OR 1.9; 95% CI 1.1 to 3.3), and pulmonary valve stenosis (OR 2.1; 95% CI 1.1 to 3.8).
We found evidence of associations between occupational exposure to solvents and several types of CHDs. These results should be interpreted in light of the potential for misclassification of exposure.
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