Higher diet quality reduces risks of neural tube defects and orofacial clefts

Details

• Alternative Title:
  Arch Pediatr Adolesc Med
• Personal Author:
  Carmichael, SL ; Yang, W ; Feldkamp, ML ; Munger, RG ; Siega-Riz, AM ; Botto, LD ; Shaw, GM
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Objective
  
  To examine whether better maternal diet quality was associated with reduced risk for selected birth defects.
  
  Design
  
  A multi-center, population-based case-control study, the National Birth Defects Prevention Study.
  
  Setting
  
  Ten participating centers in the United States.
  
  Patients/Participants
  
  Eligible subjects’ estimated due dates were from October, 1997 through December, 2005. Telephone interviews were conducted with 72% of case and 67% of control mothers. Analyses included 936 cases with neural tube defects (NTDs), 2,475 with orofacial clefts, and 6,147 non-malformed controls.
  
  Main exposures
  
  Food-frequency data were used to calculate the Mediterranean Diet Score (MDS) and Diet Quality Index (DQI), modeled after existing indices.
  
  Main outcome measures
  
  Adjusted odds ratios.
  
  Results
  
  After covariate adjustment, increasing diet quality based on either index was associated with reduced risks for the birth defects studied. The strongest association was between anencephaly and DQI; the odds ratio (OR) for highest versus lowest quartile was 0.49 (95% CI 0.31, 0.75). ORs for cleft lip+/−cleft palate and cleft palate and DQI were also notable, with ORs = 0.66 (0.54, 0.81) and 0.74 (0.56, 0.96), respectively.
  
  Conclusions
  
  Healthier maternal dietary patterns, as measured by diet quality scores, were associated with reduced risks of NTDs and clefts. These results suggest that dietary approaches could lead to further reduction in risks of major birth defects and complement existing efforts to fortify foods and encourage periconceptional multivitamin use.
  
  
• Subjects:
  Case-Control Studies Cleft Lip Cleft Palate Diet Diet Surveys Educational Status Female Humans Infant, Newborn Neural Tube Defects Obesity Pregnancy Racial Groups Smoking

  More +
• Source:
  Arch Pediatr Adolesc Med. 166(2):121-126.
• Pubmed ID:
  21969361
• Pubmed Central ID:
  PMC3973484
• Document Type:
  Journal Article
• Funding:
  1U01-DD-0006982/DD/NCBDD CDC HHS/United States ; 6U01-DD-000489/DD/NCBDD CDC HHS/United States ; R01 NS050249/NS/NINDS NIH HHS/United States ; R03 DE020112/DE/NIDCR NIH HHS/United States ; R03DE020112/DE/NIDCR NIH HHS/United States
• Place as Subject:
  United States
• Volume:
  166
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f81cf02c4a1e07d50d11b60a952c30ed437319a0ae8a2dc27311b1a03a94d4b7
• Download URL:
  https://stacks.cdc.gov/view/cdc/33670/cdc_33670_DS1.pdf
• File Type:
  [PDF - 50.58 KB ]