Cardiovascular Disease Biomarkers Predict Susceptibility or Resistance to Lung Injury in World Trade Center Dust Exposed Firefighters

Details

• Alternative Title:
  Eur Respir J
• Personal Author:
  Weiden, Michael D. ; Naveed, Bushra ; Kwon, Sophia ; Cho, Soo Jung ; Comfort, Ashley L. ; Prezant, David J. ; Rom, William N. ; Nolan, Anna
• Description:
  Pulmonary vascular loss is an early feature of chronic obstructive pulmonary disease. Biomarkers of inflammation and of metabolic syndrome predict loss of lung function in World Trade Center (WTC) lung injury (LI). We investigated if other cardiovascular disease (CVD) biomarkers also predicted WTC-LI. This nested case-cohort study used 801 never-smoker, WTC-exposed firefighters with normal pre-9/11 lung function presenting for subspecialty pulmonary evaluation (SPE) before March 2008. A representative subcohort of 124 out of 801 subjects with serum drawn within 6 months of 9/11 defined CVD biomarker distribution. Post-9/11 forced expiratory volume in 1 s (FEV1) at defined cases were as follows: susceptible WTC-LI cases with FEV1 ≤77% predicted (66 out of 801) and resistant WTC-LI cases with FEV1 ≥107% predicted (68 out of 801). All models were adjusted for WTC exposure intensity, body mass index at SPE, age on 9/11 and pre-9/11 FEV1. Susceptible WTC-LI cases had higher levels of apolipoprotein-AII, C-reactive protein and macrophage inflammatory protein-4 with significant relative risks (RRs) of 3.85, 3.93 and 0.26, respectively, with an area under the curve (AUC) of 0.858. Resistant WTC-LI cases had significantly higher soluble vascular cell adhesion molecule and lower myeloperoxidase, with RRs of 2.24 and 2.89, respectively (AUC 0.830). Biomarkers of CVD in serum 6 months post-9/11 predicted either susceptibility or resistance to WTC-LI. These biomarkers may define pathways either producing or protecting subjects from pulmonary vascular disease and associated loss of lung function after an irritant exposure.
• Subjects:
  Adult Area Under Curve Biomarkers C-Reactive Protein Cardiovascular Diseases Case-Control Studies Chemokines, CC Cohort Studies Cytokines Dust Firefighters Humans Inflammation Lung Injury Male Middle Aged Occupational Exposure Respiratory Function Tests Risk September 11 Terrorist Attacks

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• Source:
  Eur Respir J. 2012; 41(5):1023-1030.
• Pubmed ID:
  22903969
• Pubmed Central ID:
  PMC3642231
• Document Type:
  Journal Article
• Funding:
  1 UL1RR029893/RR/NCRR NIH HHS/United States ; K23 HL084191/HL/NHLBI NIH HHS/United States ; K23HL084191/HL/NHLBI NIH HHS/United States ; K24 AI080298/AI/NIAID NIH HHS/United States ; K24A1080298/PHS HHS/United States ; R01 HL057879/HL/NHLBI NIH HHS/United States ; R01 HL090316/HL/NHLBI NIH HHS/United States ; R01HL057879/HL/NHLBI NIH HHS/United States ; R01HL090316/HL/NHLBI NIH HHS/United States ; T32 ES007267/ES/NIEHS NIH HHS/United States ; TL1 RR029892/RR/NCRR NIH HHS/United States ; U01CA008617/CA/NCI NIH HHS/United States ; U10-OH008242/OH/NIOSH CDC HHS/United States ; U10-OH008243/OH/NIOSH CDC HHS/United States ; UL1 RR029893/RR/NCRR NIH HHS/United States ; UL1 TR000038/TR/NCATS NIH HHS/United States
• Place as Subject:
  New York
• Volume:
  41
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4f1d8c408aa62d135eed2f3c6d4488cbbf396aeb2fcc7d2804122bce98b07a92
• Download URL:
  https://stacks.cdc.gov/view/cdc/33548/cdc_33548_DS1.pdf
• File Type:
  [PDF - 909.83 KB ]