Cytokine profiles in children with acute intussusception in South Africa

Details

• Alternative Title:
  Cytokine
• Personal Author:
  Bessey, Theresa K. ; Parashar, Umesh D. ; Tate, Jacqueline E. ; Madhi, Shabir A. ; Jiang, Baoming ; Groome, Michelle J.
• Corporate Authors:
  The South African Intussusception Surveillance Group
• Description:
  Serum specimens of children hospitalized with acute intussusception (IS; n = 407) were analyzed for various pro- and anti-inflammatory cytokines to identify host markers specifically for IS compared to other surgical conditions (n = 235) or acute gastroenteritis (AGE; n = 68) in a cross-sectional study design. We showed that children with IS had elevated levels of pro-inflammatory cytokines IFN-γ, TNF-α, MIP-1β, IL-1β, IL-2, IL-6, IL-7, IL-8, and IL-17 as well as anti-inflammatory cytokines IL-1RA, IL-4, IL-5, and IL-13 compared to those admitted with surgical conditions or AGE symptoms, indicating these cytokines as markers for IS. In addition, we showed an increase in C-reactive protein (CRP) levels in children with IS. This study is the first to show a broad cytokine profile and identify cytokine markers in children with IS.
• Subjects:
  Acute Disease C-Reactive Protein Case-Control Studies Child Cytokines Female Humans Infant Infant, Newborn Inflammation Mediators Intussusception Male South Africa Up-Regulation

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• Keywords:
  Acute Gastroenteritis C-reactive Protein IFN-γ Pro-inflammatory Cytokines Rotavirus Vaccination Surveillance
• Source:
  Cytokine. 146:155639
• Pubmed ID:
  34284276
• Pubmed Central ID:
  PMC11325844
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  146
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f2d8704c15498a3be1d8945700f6f87bda63241bcee504e5c378013c6ce36da4bf0d24bc2fa6720f1a791fe001bf510293884ff729e6acdd878ff6d1ac146d18
• Download URL:
  https://stacks.cdc.gov/view/cdc/160174/cdc_160174_DS1.pdf
• File Type:
  [PDF - 452.06 KB ]