Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Zanetti, G. ; Giardina, R. ; Platt, R.
Zanetti, G. ; Giardina, R. ; Platt, R. Less -
Description:
Intraoperative redosing of prophylactic antibiotics is recommended for prolonged surgical procedures, although its efficacy has not been assessed. We retrospectively compared the risk of surgical site infections in 1,548 patients who underwent cardiac surgery lasting >240 min after preoperative administration of cefazolin prophylaxis. The overall risk of surgical site infection was similar among patients with (43 [9.4%] of 459) and without (101 [9.3%] of 1,089) intraoperative redosing (odds ratio [OR] 1.01, 95% confidence interval [CI] 0.70-1.47). However, redosing was beneficial in procedures lasting >400 min: infection occurred in 14 (7.7%) of 182 patients with redosing and in 32 (16.0%) of 200 patients without (adjusted OR 0.44, 95% CI 0.23-0.86). Intraoperative redosing of cefazolin was associated with a 16% reduction in the overall risk for surgical site infection after cardiac surgery, including procedures lasting <240 min.
Subjects:
[+]
Adolescent Adult Aged Aged, 80 And Over Antibiotic Prophylaxis Cardiac Surgical Procedures Cefazolin Cephalosporins Drug Administration Schedule Female Humans Intraoperative Care Male Middle Aged Research Article Retrospective Studies Risk Factors Surgical Wound Infection Time Factors
Source:
Emerg Infect Dis. 7(5):828-831.
Pubmed ID:
11791504
Pubmed Central ID:
PMC2631868
Document Type:
Journal Article
Funding:
UR8/CCU115079/CC/ODCDC CDC HHS/United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:5238511badf5520f2d80d4fbd200725d0cf6f8c4653812f6066bc60ba7a741ea
Download URL:
https://stacks.cdc.gov/view/cdc/3352/cdc_3352_DS1.pdf
File Type:

Supporting Files

• 	11791504.nxml	txt
  	license.txt	txt

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