Descriptive Epidemiology of Nonsyndromic Complete Atrioventricular Canal Defects

Agopian, A. J.; Moulik, Mousumi; Gupta-Malhotra, Monesha; Marengo, Lisa K.; Mitchell, Laura E.

doi:10.1111/ppe.12006

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Descriptive Epidemiology of Nonsyndromic Complete Atrioventricular Canal Defects

Published Date:

Sep 24 2012

Publisher's site:

http://dx.doi.org/10.1111/ppe.12006 New Site Icon

Source:

Paediatr Perinat Epidemiol. 26(6):515-524.

[PDF - 59.74 KB]

Details:

Personal Authors:

Agopian, A. J. ; Moulik, Mousumi ; Gupta-Malhotra, Monesha ; Marengo, Lisa K. ; Mitchell, Laura E. ;

Keywords:

[+]

Pubmed ID:

23061687

Pubmed Central ID:

PMC3482101

Description:

Background

Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated nonsyndromic CAVC. Risk factors for nonsyndromic CAVC have not been well established.

Methods

To assess the relationship between risk for nonsyndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 nonsyndromic cases with CAVC.

Results

Significant associations were observed between nonsyndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR): 6.74, 95% confidence interval (CI): 3.67–12.37), gestational diabetes [aPR: 1.69, 95% CI: 1.03, 2.79], and obesity [aPR: 1.69, 95% CI: 1.24, 2.30].

Comments

Our findings add nonsyndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

5K08HL091176-04/HL/NHLBI NIH HHS/United States
5K23HL089301-02/HL/NHLBI NIH HHS/United States
5U01DD000494/DD/NCBDD CDC HHS/United States
K08 HL091176/HL/NHLBI NIH HHS/United States
K23 HL089391/HL/NHLBI NIH HHS/United States

Supporting Files:

NIHMS404540-supplement-Table_S1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
nihms404540.nxml	text/plain

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