Descriptive Epidemiology of Nonsyndromic Complete Atrioventricular Canal Defects
Published Date:Sep 24 2012
Source:Paediatr Perinat Epidemiol. 26(6):515-524.
Pubmed Central ID:PMC3482101
Funding:5K08HL091176-04/HL/NHLBI NIH HHS/United States
5K23HL089301-02/HL/NHLBI NIH HHS/United States
5U01DD000494/DD/NCBDD CDC HHS/United States
K08 HL091176/HL/NHLBI NIH HHS/United States
K23 HL089391/HL/NHLBI NIH HHS/United States
Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated nonsyndromic CAVC. Risk factors for nonsyndromic CAVC have not been well established.
To assess the relationship between risk for nonsyndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 nonsyndromic cases with CAVC.
Significant associations were observed between nonsyndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR): 6.74, 95% confidence interval (CI): 3.67–12.37), gestational diabetes [aPR: 1.69, 95% CI: 1.03, 2.79], and obesity [aPR: 1.69, 95% CI: 1.24, 2.30].
Our findings add nonsyndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.
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