Descriptive Epidemiology of Nonsyndromic Complete Atrioventricular Canal Defects

Agopian, A. J.; Moulik, Mousumi; Gupta-Malhotra, Monesha; Marengo, Lisa K.; Mitchell, Laura E.

doi:10.1111/ppe.12006

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Descriptive Epidemiology of Nonsyndromic Complete Atrioventricular Canal Defects

Published Date:

Sep 24 2012

Publisher's site:

http://dx.doi.org/10.1111/ppe.12006 New Site Icon

Source:

Paediatr Perinat Epidemiol. 26(6):515-524.

[PDF-59.74 KB]

Details:

Personal Authors:

Agopian, A. J. ; Moulik, Mousumi ; Gupta-Malhotra, Monesha ; Marengo, Lisa K. ; Mitchell, Laura E. ;

Keywords:

[+]

Pubmed ID:

23061687

Pubmed Central ID:

PMC3482101

Description:

Background

Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated nonsyndromic CAVC. Risk factors for nonsyndromic CAVC have not been well established.

Methods

To assess the relationship between risk for nonsyndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 nonsyndromic cases with CAVC.

Results

Significant associations were observed between nonsyndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR): 6.74, 95% confidence interval (CI): 3.67–12.37), gestational diabetes [aPR: 1.69, 95% CI: 1.03, 2.79], and obesity [aPR: 1.69, 95% CI: 1.24, 2.30].

Comments

Our findings add nonsyndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

5K08HL091176-04/HL/NHLBI NIH HHS/United States
5K23HL089301-02/HL/NHLBI NIH HHS/United States
5U01DD000494/DD/NCBDD CDC HHS/United States
K08 HL091176/HL/NHLBI NIH HHS/United States
K23 HL089391/HL/NHLBI NIH HHS/United States

Supporting Files:

	NIHMS404540-supplement-Table_S1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	nihms404540.nxml	text/plain

No Related Documents.

You May Also Like:

Laterality Defects in the National Birth Defects Prevention Study (1998–2007): Birth Prevalence and Descriptive Epidemiology

Personal Author:

Lin, Angela E.; Krikov, Sergey; Riehle-Colarusso, Tiffany; Frías, Jaime L.; Belmont, John; Anderka, Marlene; Geva, Tal; Getz, Kelly D.; Botto, Lorenzo D.;

Corporate Author:

National Birth Defects Prevention Study

Published:

Aug 06 2014

Source:

Am J Med Genet A. 2014; 0(10):2581-2591.

Description:

Little is known epidemiologically about laterality defects. Using data from the National Birth Defects Prevention Study (NBDPS), a large multi-site case-control study of birth defects, we analyzed prevalence and selected characteristics in children b...

File Type:

[PDF - 422.55 KB]
Analysis of Selected Maternal Exposures and Non-Syndromic Atrioventricular Septal Defects in the National Birth Defects Prevention Study, 1997–2005

Personal Author:

Patel, Sonali S.; Burns, Trudy L.; Botto, Lorenzo D.; Riehle-Colarusso, Tiffany J.; Lin, Angela E.; Shaw, Gary M.; Romitti, Paul A.;

Published:

Aug 17 2012

Source:

Am J Med Genet A. 2012; 0(10):2447-2455.

Description:

Although the descriptive epidemiology of atrioventricular septal defects (AVSDs), a group of serious congenital heart defects (CHDs), has been recently reported, non-genetic risk factors have not been consistently identified. Using data (1997-2005) f...

File Type:

[PDF - 225.92 KB]
Prenatal Diagnosis of Non-Syndromic Congenital Heart Defects

Personal Author:

Ailes, Elizabeth C.; Gilboa, Suzanne M.; Riehle-Colarusso, Tiffany; Johnson, Candice Y.; Hobbs, Charlotte A.; Correa, Adolfo; Honein, Margaret A.;

Corporate Author:

National Birth Defects Prevention Study

Published:

Dec 17 2013

Source:

Prenat Diagn. 34(3):214-222.

Description:

Objectives : Congenital heart defects (CHDs) occur in nearly 1% of live births. We sought to assess factors associated with prenatal CHD diagnosis in the National Birth Defects Prevention Study (NBDPS). : Methods : We analyzed data from mothers with ...

File Type:

[PDF - 1.80 MB]
Vasoactive Exposures during Pregnancy and Risk of Microtia

Personal Author:

Van Bennekom, Carla M.; Mitchell, Allen A.; Moore, Cynthia A.; Werler, Martha M.;

Published:

Nov 24 2012

Source:

Birth Defects Res A Clin Mol Teratol. 97(1):53-59.

Description:

Background : Little is known about the etiology of nonsyndromic microtia. This study investigated the hypothesis that microtia is caused by vascular disruption. : Methods : The study analyzed data from the population-based National Birth Defects Prev...

File Type:

[PDF - 216.78 KB]
Late Detection of Critical Congenital Heart Disease Among US Infants

Personal Author:

Peterson, Cora; Ailes, Elizabeth; Riehle-Colarusso, Tiffany; Oster, Matthew E.; Olney, Richard S.; Cassell, Cynthia H.; Fixler, David E.; Carmichael, Suzan L.; Shaw, Gary M.; Gilboa, Suzanne M.;

Published:

Apr 2014

Source:

JAMA Pediatr. 2014; 168(4):361-370.

Description:

IMPORTANCE : Critical congenital heart disease (CCHD) was added to the Recommended Uniform Screening Panel for Newborns in the United States in 2011. Many states have recently adopted or are considering requirements for universal CCHD screening throu...

File Type:

[PDF - 594.33 KB]