Details:

Alternative Title:
Paediatr Perinat Epidemiol
Publisher's site:
http://dx.doi.org/10.1111/ppe.12006
Personal Author:
Agopian, A. J. ; Moulik, Mousumi ; Gupta-Malhotra, Monesha ; Marengo, Lisa K. ; Mitchell, Laura E.
Agopian, A. J. ; Moulik, Mousumi ; Gupta-Malhotra, Monesha ; Marengo, Lisa K. ; Mitchell, Laura E. Less -
Description:
Background

Complete atrioventricular canal defects (CAVC) are a common heart defect, but few epidemiologic studies have evaluated nonsyndromic CAVC. Risk factors for nonsyndromic CAVC have not been well established.

Methods

To assess the relationship between risk for nonsyndromic CAVC in offspring and several sociodemographic and reproductive parental factors, including maternal diabetes and obesity, we conducted Poisson regression analyses, using data ascertained through the Texas Birth Defects Registry, a large, population-based birth defects registry. Data were evaluated for 563 nonsyndromic cases with CAVC.

Results

Significant associations were observed between nonsyndromic CAVC in offspring and maternal pregestational diabetes (adjusted prevalence ratio (aPR): 6.74, 95% confidence interval (CI): 3.67–12.37), gestational diabetes [aPR: 1.69, 95% CI: 1.03, 2.79], and obesity [aPR: 1.69, 95% CI: 1.24, 2.30].

Comments

Our findings add nonsyndromic CAVC to the growing list of birth defects that appear to be associated with maternal diabetes and obesity.


Subject:
[+]
Article
Diabetes, Gestational
Endocardial Cushion Defects
Female
Humans
Male
Marital Status
Maternal Age
Obesity
Pregnancy
Pregnancy In Diabetics
Registries
Regression Analysis
Risk Factors
Socioeconomic Factors

Source:
Paediatr Perinat Epidemiol. 26(6):515-524.
Pubmed ID:
23061687
Pubmed Central ID:
PMC3482101
Document Type:
Journal Article
Funding:
5K08HL091176-04/HL/NHLBI NIH HHS/United States ; 5K23HL089301-02/HL/NHLBI NIH HHS/United States ; 5U01DD000494/DD/NCBDD CDC HHS/United States ; K08 HL091176/HL/NHLBI NIH HHS/United States ; K23 HL089391/HL/NHLBI NIH HHS/United States
5K08HL091176-04/HL/NHLBI NIH HHS/United States ; 5K23HL089301-02/HL/NHLBI NIH HHS/United States ; 5U01DD000494/DD/NCBDD CDC HHS/United States ; K08 HL091176/HL/NHLBI NIH HHS/United States ; K23 HL089391/HL/NHLBI NIH HHS/United States Less -
Place as Subject:
Texas
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e86b27188ae9386de88f528929b02dd688a6671f8d2e3b6b9d60b5f2492ef0c3
File Type:

Supporting Files

• 	NIHMS404540-supplement-Table_S1.docx	docx
  	nihms404540.nxml	txt

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