Details:

Alternative Title:
Cancer Causes Control
Personal Author:
Contreras, Zuelma A ; Ritz, Beate ; Virk, Jasveer ; Cockburn, Myles ; Heck, Julia E
Contreras, Zuelma A ; Ritz, Beate ; Virk, Jasveer ; Cockburn, Myles ; Heck, Julia E Less -
Description:
Purpose

We aimed to examine the influence of pre-pregnancy diabetes, pre-pregnancy body mass index (BMI), gestational diabetes, and gestational weight gain on childhood cancer risk in offspring.

Methods

We identified cancer cases (n=11,149) younger than age 6 years at diagnosis from the California Cancer Registry registered between 1988–2013. Controls (n=270,147) were randomly sampled from California birth records, and frequency-matched by year of birth to all childhood cancers during the study period. Exposure and covariate information was extracted from birth records. Unconditional logistic regression models were generated to assess the importance of pre-pregnancy diabetes, pre-pregnancy BMI, gestational diabetes, and gestational weight gain on childhood cancer risk.

Results

We observed increased risks of acute lymphoblastic leukemia (ALL) and Wilms’ tumor in children of mothers with pre-pregnancy diabetes [odds ratio (OR) =1.37, 95% confidence interval (CI): (1.11, 1.69), OR=1.45, 95% CI: (0.97, 2.18), respectively]. When born to mothers who were overweight prior to pregnancy (BMI 25–<30), children were at increased risk of leukemia [OR=1.27, 95% CI: (1.01, 1.59)]. Insufficient gestational weight gain increased the risk of acute myeloid leukemia (AML) [OR=1.50 (95% CI: 0.92, 2.42)] while excessive gestational weight gain increased the risk of astrocytomas [OR=1.56, 95% CI: (0.97, 2.50)]. No associations were found between gestational diabetes and childhood cancer risk in offspring.

Conclusions

We estimated elevated risks of several childhood cancers in the offspring of mothers who had diabetes and were overweight prior to pregnancy, as well as mothers who gained insufficient or excessive weight. Since few studies have focused on these factors in relation to childhood cancer, replication of our findings in future studies is warranted.


Subject:
[+]
Adult
Article
Birth Weight
BMI
Body Mass Index
California
Child
Childhood Cancer Epidemiology
Diabetes
Diabetes, Gestational
Female
Gestational Weight Gain
Humans
Logistic Models
Male
Neoplasms
Obesity
Odds Ratio
Overweight
Pregnancy
Pregnancy Complications
Pregnancy In Diabetics
Risk Factors
Weight Gain

Source:
Cancer Causes Control. 27(10):1273-1285
Pubmed ID:
27613707
Pubmed Central ID:
PMC5066566
Document Type:
Journal Article
Funding:
HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; R21 ES018960/ES/NIEHS NIH HHS/United States ; T32 CA009142/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; ... More +
HHSN261201000140C/CA/NCI NIH HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; R21 ES018960/ES/NIEHS NIH HHS/United States ; T32 CA009142/CA/NCI NIH HHS/United States ; HHSN261201000035I/CA/NCI NIH HHS/United States ; R21 ES019986/ES/NIEHS NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP003862/DP/NCCDPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e67123ce21ee6cdbebd0475eed754ec27f59105afafbf234cae9a80dcb53bfa4
File Type:

Supporting Files

• 	NIHMS815903-supplement-10552_2016_807_MOESM1_ESM.docx	docx
  	nihms815903.nxml	xml

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