Details:

Alternative Title:
Ultrasound Med Biol
Publisher's site:
http://dx.doi.org/10.1016/j.ultrasmedbio.2012.04.015
Personal Author:
Treat, Lisa H. ; McDannold, Nathan ; Zhang, Yongzhi ; Vykhodtseva, Natalia ; Hynynen, Kullervo
Treat, Lisa H. ; McDannold, Nathan ; Zhang, Yongzhi ; Vykhodtseva, Natalia ; Hynynen, Kullervo Less -
Description:
The blood-brain barrier (BBB) inhibits the entry of the majority of chemotherapeutic agents into the brain. Previous studies have illustrated the feasibility of drug delivery across the BBB using focused ultrasound (FUS) and microbubbles. Here, we investigated the effect of FUS-enhanced delivery of doxorubicin on survival in rats with and 9L gliosarcoma cells inoculated in the brain. Each rat received either: (1) no treatment (control; N = 11), (2) FUS only (N = 9), (3) IV liposomal doxorubicin (DOX only; N = 17), or (4) FUS with concurrent IV injections of liposomal doxorubicin (FUS+DOX; N = 20). Post-treatment by magnetic resonance imaging (MRI) showed that FUS+DOX reduced tumor growth compared with DOX only. Further, we observed a modest but significant increase in median survival time after a single treatment FUS+DOX treatment (p = 0.0007), whereas neither DOX nor FUS had any significant impact on survival on its own. These results suggest that combined ultrasound-mediated BBB disruption may significantly increase the antineoplastic efficacy of liposomal doxorubicin in the brain.
Subjects:
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9L Gliosarcoma Animals Antineoplastic Agents Article Blood-brain Barrier Brain Neoplasms Cell Line, Tumor Doxorubicin Focused Ultrasound Gliosarcoma Liposomes Magnetic Resonance Imaging, Interventional Male Microbubbles Rats Rats, Sprague-Dawley Sonication Survival Treatment Outcome
Source:
Ultrasound Med Biol. 2012; 38(10):1716-1725.
Pubmed ID:
22818878
Pubmed Central ID:
PMC3438387
Document Type:
Journal Article
Funding:
41PR019703/PR/OCPHP CDC HHS/United States ; P41 EB015898/EB/NIBIB NIH HHS/United States ; P41 RR019703/RR/NCRR NIH HHS/United States ; P41EB015898/EB/NIBIB NIH HHS/United States ; R01 EB003268/EB/NIBIB NIH HHS/United States ; ... More +
41PR019703/PR/OCPHP CDC HHS/United States ; P41 EB015898/EB/NIBIB NIH HHS/United States ; P41 RR019703/RR/NCRR NIH HHS/United States ; P41EB015898/EB/NIBIB NIH HHS/United States ; R01 EB003268/EB/NIBIB NIH HHS/United States ; R01EB003268/EB/NIBIB NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4bafb06899fea1fef6373f78dd4f5d511803f40492470f38efea6a79d7f880e7
Download URL:
https://stacks.cdc.gov/view/cdc/33426/cdc_33426_DS1.pdf
File Type:

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