A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

Pergadia, Michele L.; Glowinski, Anne L.; Wray, Naomi R.; Agrawal, Arpana; Saccone, Scott F.; Loukola, Anu; Broms, Ulla; Korhonen, Tellervo; Penninx, Brenda W.J.H.; Grant, Julia D.; Nelson, Elliot C.; Henders, Anjali K.; Schrage, Andrew J.; Chou, Yi-Ling; Keskitalo-Vuokko, Kaisu; Zhu, Qin; Gordon, Scott D.; Vink, Jacqueline M.; de Geus, Eco J.C.; MacGregor, Stuart; Liu, Jimmy Z.; Willemsen, Gonneke; Medland, Sarah E.; Boomsma, Dorret I.; Montgomery, Grant W.; Rice, John P.; Goate, Alison M.; Heath, Andrew C.; Kaprio, Jaakko; Martin, Nicholas G.; Madden, Pamela A.F.

doi:10.1176/appi.ajp.2011.10091319

Back to Previous Page

A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

Published Date:

May 15 2011

Publisher's site:

http://dx.doi.org/10.1176/appi.ajp.2011.10091319

Source:

Am J Psychiatry. 168(8):848-852.

Language:

English

[PDF-294.86 KB]

Details:

Alternative Title:

Am J Psychiatry

Personal Author:

Pergadia, Michele L. ; Glowinski, Anne L. ; Wray, Naomi R. ; Agrawal, Arpana ; Saccone, Scott F. ; ... More ▼

Description:

Objective The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking. Method Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pair design, the authors conducted nonparametric linkage analysis. Results In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). Conclusions Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.

Subject:

[+]

Pubmed ID:

21572167

Pubmed Central ID:

PMC3433250

Document Type:

Journal Article

Funding:

AA011998/AA/NIAAA NIH HHS/United States ; AA015210/AA/NIAAA NIH HHS/United States ; AA017688/AA/NIAAA NIH HHS/United States ; AA017915/AA/NIAAA NIH HHS/United States ; AA07580/AA/NIAAA NIH HHS/United States ; ... More ▼

Place as Subject:

Finland

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

File Type:

Supporting Files:

	NIHMS397801-supplement-1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS397801-supplement-2.xls	application/vnd.ms-excel
	nihms397801.nxml	text/plain
	nihms397801f1.gif	image/gif
	nihms397801f1.jpg	image/jpeg

No Related Documents.

Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

[PDF - 692.77 KB]

Personal Author:

Lill, Christina M. ; Roehr, Johannes T. ; ...

Corporate Authors:

23andMe, The Genetic Epidemiology of Parkinson's Disease (GEO-PD) Consortium ; The International Parkinson's Disease Genomics Consortium (IPDGC) ; ...

Published Date:

Mar 15 2012

Source:

PLoS Genet. 2012; 8(3).

Description:

More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the inter...

File Type:

[PDF - 692.77 KB]

File Type:

[PDF - 692.77 KB]
A genome-wide association study of marginal zone lymphoma shows association to the HLA region

[PDF - 518.47 KB]

Personal Author:

Vijai, Joseph ; Wang, Zhaoming ; ...

Published Date:

January 08 2015

Source:

Nat Commun. 6:5751

Description:

Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and ...

File Type:

[PDF - 518.47 KB]

File Type:

[PDF - 518.47 KB]
Parent-Of-Origin Effects in Autism Identified through Genome-Wide Linkage Analysis of 16,000 SNPs

[PDF - 404.12 KB]

Personal Author:

Fradin, Delphine ; Cheslack-Postava, Keely ; ...

Published Date:

Sep 02 2010

Source:

PLoS One. 5(9).

Description:

BackgroundAutism is a common heritable neurodevelopmental disorder with complex etiology. Several genome-wide linkage and association scans have been ...

File Type:

[PDF - 404.12 KB]

File Type:

[PDF - 404.12 KB]
Age-specific genome-wide association study in glioblastoma identifies increased proportion of ‘lower grade glioma’-like features associated with younger age

[PDF - 717.18 KB]

Personal Author:

Ostrom, Quinn T. ; Kinnersley, Ben ; ...

Published Date:

September 19 2018

Source:

Int J Cancer. 143(10):2359-2366

Description:

Glioblastoma (GBM) is the most common malignant brain tumor in the United States. Incidence of GBM increases with age, and younger age-at-diagnosis is...

File Type:

[PDF - 717.18 KB]

File Type:

[PDF - 717.18 KB]
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

[PDF - 1.02 MB]

Personal Author:

Melin, Beatrice S ; Barnholtz-Sloan, Jill S ; ...

Corporate Authors:

GliomaScan Consortium

Published Date:

March 27 2017

Source:

Nat Genet. 49(5):789-794

Description:

Genome-wide association studies (GWAS) have transformed our understanding of glioma susceptibility, but individual studies have had limited power to i...

File Type:

[PDF - 1.02 MB]

File Type:

[PDF - 1.02 MB]

A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

You May Also Like:

Have Questions?

CDC INFORMATION

CONNECT WITH CDC