A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

Pergadia, Michele L.; Glowinski, Anne L.; Wray, Naomi R.; Agrawal, Arpana; Saccone, Scott F.; Loukola, Anu; Broms, Ulla; Korhonen, Tellervo; Penninx, Brenda W.J.H.; Grant, Julia D.; Nelson, Elliot C.; Henders, Anjali K.; Schrage, Andrew J.; Chou, Yi-Ling; Keskitalo-Vuokko, Kaisu; Zhu, Qin; Gordon, Scott D.; Vink, Jacqueline M.; de Geus, Eco J.C.; MacGregor, Stuart; Liu, Jimmy Z.; Willemsen, Gonneke; Medland, Sarah E.; Boomsma, Dorret I.; Montgomery, Grant W.; Rice, John P.; Goate, Alison M.; Heath, Andrew C.; Kaprio, Jaakko; Martin, Nicholas G.; Madden, Pamela A.F.

doi:10.1176/appi.ajp.2011.10091319

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

Published Date:

May 15 2011

Publisher's site:

http://dx.doi.org/10.1176/appi.ajp.2011.10091319 New Site Icon

Source:

Am J Psychiatry. 168(8):848-852.

[PDF-294.86 KB]

Details:

Personal Authors:

Pergadia, Michele L. ; Glowinski, Anne L. ; Wray, Naomi R. ; Agrawal, Arpana ; Saccone, Scott F. ; ... More ▼

Keywords:

[+]

Pubmed ID:

21572167

Pubmed Central ID:

PMC3433250

Description:

Objective

The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking.

Method

Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pair design, the authors conducted nonparametric linkage analysis.

Results

In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25).

Conclusions

Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Supporting Files:

	NIHMS397801-supplement-1.docx	application/vnd.openxmlformats-officedocument.wordprocessingml.document
	NIHMS397801-supplement-2.xls	application/vnd.ms-excel
	nihms397801.nxml	text/plain
	nihms397801f1.gif	image/gif
	nihms397801f1.jpg	image/jpeg

No Related Documents.

You May Also Like:

How tobacco smoke causes disease; the biology and behavioral basis for smoking-attributable disease : a report of the Surgeon General

Corporate Author:

United States, Public Health Service., Office of the Surgeon General.. Centers for Disease Control and Prevention (U.S.). National Center for Chronic Disease Prevention and Health Promotion (U.S.), Office on Smoking and Health..

Published:

2010

Description:

In 1964, the first Surgeon General's report on the effects of smoking on health was released. In the nearly 50 years since, extensive data from thousands of studies have consistently substantiated the devastating effects of smoking on the lives of mi...

File Type:

[PDF - 13.36 MB]
Fetal alcohol spectrum disorders; competency-based curriculum development guide for medical and allied health education and practice

Corporate Author:

National Center on Birth Defects and Developmental Disabilities (Centers for Disease Control and Prevention). Centers for Disease Control and Prevention (U.S.). National Organization on Fetal Alcohol Syndrome.

Published:

2009

Description:

"The Fetal Alcohol Spectrum Disorders (FASD) Competency-Based Curriculum Development Guide for Medical and Allied Health Education and Practice was developed by the FASD Regional Training Centers (RTCs), the Centers for Disease Control and Prevention...

File Type:

[PDF - 1.88 MB]
The relationship between cannabis involvement and suicidal thoughts and behaviors

Personal Author:

Delforterie, M. J.; Lynskey, M.; Huizink, A. C.; Creemers, H. E.; Grant, J.D.; Few, L. R.; Glowinski, A. L.; Statham, D. J.; Trull, T. J.; Bucholz, K. K.; Madden, P. A. F.; Martin, N. G.; Heath, A. C.; Agrawal, A.;

Published:

Feb 26 2015

Source:

Drug Alcohol Depend. 150:98-104.

Description:

Background : In the present study, we examined the relationship between cannabis involvement and suicidal ideation (SI), plan and attempt, differentiating the latter into planned and unplanned attempt, taking into account other substance involvement ...

File Type:

[PDF - 292.65 KB]
Characteristics of adults with serious psychological distress as measured by the K6 scale, United States, 2001-04

Personal Author:

Pratt, Laura A.; Dey, Achintya N.; Cohen, Alan J.;

Corporate Author:

National Center for Health Statistics (U.S.). Centers for Disease Control and Prevention (U.S.).

Published:

March 30, 2007

Series:

Advance data from vital and health statistics of the National Center for Health Statistics ; no. 382

Description:

"OBJECTIVE: This report estimates the prevalence of serious psychological distress (SPD) in the noninstitutionalized adult population of the United States, as measured by the K6 scale of nonspecific psychological distress, and describes the character...

File Type:

[PDF - 310.95 KB]
Genomics and Autism Spectrum Disorder

Personal Author:

Johnson, Norah L.; Giarelli, Ellen; Lewis, Celine; Rice, Catherine E.;

Published:

Jan 31 2013

Source:

J Nurs Scholarsh. 2013; 45(1):69-78.

Description:

Purpose : To present the current state of the evidence regarding translation of genetics (the study of single genes) and genomics (the study of all genes and gene-gene or gene-environment interactions) into health care of children with autism spectru...

File Type:

[PDF - 131.77 KB]