Content
and Copyright
i
Superseded
This Document Has Been Replaced By:
i
Retired
This Document Has Been Retired
i
Up-to-date Information
This is the latest update:
A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families
-
Published Date:
May 15 2011
-
Publisher's site:
-
Source:Am J Psychiatry. 168(8):848-852.
-
Language:English
-
[PDF-294.86 KB]
Details:
-
Alternative Title:Am J Psychiatry
-
Personal Author:
-
Description:Objective The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking. Method Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pair design, the authors conducted nonparametric linkage analysis. Results In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25). Conclusions Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.
-
Subject:
-
Pubmed ID:21572167
-
Pubmed Central ID:PMC3433250
-
Document Type:
-
Funding:
-
Place as Subject:
-
Collection(s):
-
Main Document Checksum:
- File Type:
-
Supporting Files:
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/vnd.ms-excel 
text/plain 
image/gif 
image/jpeg
No Related Documents.
Email
CDC-INFO
