A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

Pergadia, Michele L.; Glowinski, Anne L.; Wray, Naomi R.; Agrawal, Arpana; Saccone, Scott F.; Loukola, Anu; Broms, Ulla; Korhonen, Tellervo; Penninx, Brenda W.J.H.; Grant, Julia D.; Nelson, Elliot C.; Henders, Anjali K.; Schrage, Andrew J.; Chou, Yi-Ling; Keskitalo-Vuokko, Kaisu; Zhu, Qin; Gordon, Scott D.; Vink, Jacqueline M.; de Geus, Eco J.C.; MacGregor, Stuart; Liu, Jimmy Z.; Willemsen, Gonneke; Medland, Sarah E.; Boomsma, Dorret I.; Montgomery, Grant W.; Rice, John P.; Goate, Alison M.; Heath, Andrew C.; Kaprio, Jaakko; Martin, Nicholas G.; Madden, Pamela A.F.

doi:10.1176/appi.ajp.2011.10091319

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A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

Published Date:

May 15 2011

Publisher's site:

http://dx.doi.org/10.1176/appi.ajp.2011.10091319 New Site Icon

Source:

Am J Psychiatry. 168(8):848-852.

[PDF-294.86 KB]

Details:

Personal Authors:

Pergadia, Michele L. ; Glowinski, Anne L. ; Wray, Naomi R. ; Agrawal, Arpana ; Saccone, Scott F. ; ... More ▼

Keywords:

[+]

Pubmed ID:

21572167

Pubmed Central ID:

PMC3433250

Description:

Objective

The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking.

Method

Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pair design, the authors conducted nonparametric linkage analysis.

Results

In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25).

Conclusions

Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

Supporting Files:

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