A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families

Details

• Alternative Title:
  Am J Psychiatry
• Personal Author:
  Pergadia, Michele L. ; Glowinski, Anne L. ; Wray, Naomi R. ; Agrawal, Arpana ; Saccone, Scott F. ; Loukola, Anu ; Broms, Ulla ; Korhonen, Tellervo ; Penninx, Brenda W.J.H. ; Grant, Julia D. ; Nelson, Elliot C. ; Henders, Anjali K. ; Schrage, Andrew J. ; Chou, Yi-Ling ; Keskitalo-Vuokko, Kaisu ; Zhu, Qin ; Gordon, Scott D. ; Vink, Jacqueline M. ; de Geus, Eco J.C. ; MacGregor, Stuart ; Liu, Jimmy Z. ; Willemsen, Gonneke ; Medland, Sarah E. ; Boomsma, Dorret I. ; Montgomery, Grant W. ; Rice, John P. ; Goate, Alison M. ; Heath, Andrew C. ; Kaprio, Jaakko ; Martin, Nicholas G. ; Madden, Pamela A.F.
• Description:
  Objective
  
  The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking.
  
  Method
  
  Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pair design, the authors conducted nonparametric linkage analysis.
  
  Results
  
  In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25).
  
  Conclusions
  
  Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.
  
  
• Subjects:
  Adult Alleles Article Chromosomes, Human, Pair 3 Depressive Disorder, Major Diagnostic And Statistical Manual Of Mental Disorders Diseases In Twins Genetic Linkage Genome-Wide Association Study Genotype Humans Lod Score Polymorphism, Single Nucleotide Queensland Receptors, Metabotropic Glutamate Smoking

  More +
• Source:
  Am J Psychiatry. 168(8):848-852.
• Pubmed ID:
  21572167
• Pubmed Central ID:
  PMC3433250
• Document Type:
  Journal Article
• Funding:
  AA011998/AA/NIAAA NIH HHS/United States ; AA015210/AA/NIAAA NIH HHS/United States ; AA017688/AA/NIAAA NIH HHS/United States ; AA017915/AA/NIAAA NIH HHS/United States ; AA07580/AA/NIAAA NIH HHS/United States ; AA07728/AA/NIAAA NIH HHS/United States ; AA11998/AA/NIAAA NIH HHS/United States ; AA13320/AA/NIAAA NIH HHS/United States ; AA13321/AA/NIAAA NIH HHS/United States ; DA018267/DA/NIDA NIH HHS/United States ; DA024722/DA/NIDA NIH HHS/United States ; DA027995/DA/NIDA NIH HHS/United States ; DA12854/DA/NIDA NIH HHS/United States ; DA23668/DA/NIDA NIH HHS/United States ; K01 DA024722/DA/NIDA NIH HHS/United States ; K05 AA017688/AA/NIAAA NIH HHS/United States ; K08 DA019951/DA/NIDA NIH HHS/United States ; K08 DA019951-05/DA/NIDA NIH HHS/United States ; MH-073151/MH/NIMH NIH HHS/United States ; MH-081802/MH/NIMH NIH HHS/United States ; P60 AA011998/AA/NIAAA NIH HHS/United States ; R01 AA007728/AA/NIAAA NIH HHS/United States ; R01 AA013320/AA/NIAAA NIH HHS/United States ; R01 AA013321/AA/NIAAA NIH HHS/United States ; R01 AA015210/AA/NIAAA NIH HHS/United States ; R01 AA017915/AA/NIAAA NIH HHS/United States ; R01 DA012854/DA/NIDA NIH HHS/United States ; R01 DA018267/DA/NIDA NIH HHS/United States ; R01 DA023668/DA/NIDA NIH HHS/United States ; R01 MH-059160/MH/NIMH NIH HHS/United States ; R01 MH059160/MH/NIMH NIH HHS/United States ; R01 MH073151/MH/NIMH NIH HHS/United States ; R01 MH081802/MH/NIMH NIH HHS/United States ; R25 DA027995/DA/NIDA NIH HHS/United States ; R49CE001510/CE/NCIPC CDC HHS/United States ; T32 AA007580/AA/NIAAA NIH HHS/United States
• Place as Subject:
  Finland
• Volume:
  168
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7f425a9632c2d88ae58de2b91ae7ec3d1fb1db6291ac87372c149b34159e3811
• Download URL:
  https://stacks.cdc.gov/view/cdc/33424/cdc_33424_DS1.pdf
• File Type:
  [PDF - 294.86 KB ]