i
A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families
-
May 15 2011
Source: Am J Psychiatry. 168(8):848-852. -
Alternative Title:Am J Psychiatry
-
Publisher's site:
-
Personal Author:
-
Description:Objective
The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking.
Method
Within a study that targeted families characterized by a history of smoking, analyses derived a subset of 91 Australian families with two or more offspring with a history of DSM-IV major depressive disorder (affected sibling pairs, N=187) and 25 Finnish families (affected sibling pairs, N=33). Within this affected sibling pair design, the authors conducted nonparametric linkage analysis.
Results
In the Australian heavy smoking families, the authors found a genome-wide significant multipoint LOD score of 4.14 for major depressive disorder on chromosome 3 at 24.9 cM (3p26-3p25).
Conclusions
Genome-wide significant linkage was detected for major depressive disorder on chromosome 3p in a sample ascertained for smoking. A linkage peak at this location was also observed in an independent study of major depressive disorder.
-
Subjects:
-
Source:
-
Pubmed ID:21572167
-
Pubmed Central ID:PMC3433250
-
Document Type:
-
Funding:
-
Place as Subject:
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
[PDF-294.86 KB]
Details:
Supporting Files
More +
Email
CDC-INFO
