Details:

Alternative Title:
Cell
Publisher's site:
http://dx.doi.org/10.1016/j.cell.2012.07.009
Personal Author:
Lachance, Joseph ; Vernot, Benjamin ; Elbers, Clara C. ; Ferwerda, Bart ; Froment, Alain ; ... More +
Lachance, Joseph ; Vernot, Benjamin ; Elbers, Clara C. ; Ferwerda, Bart ; Froment, Alain ; Bodo, Jean-Marie ; Lema, Godfrey ; Fu, Wenqing ; Nyambo, Thomas B. ; Rebbeck, Timothy R. ; Zhang, Kun ; Akey, Joshua M. ; Tishkoff, Sarah A. ; Less -
Description:
To reconstruct modern human evolutionary history and identify loci that have shaped hunter-gatherer adaptation, we sequenced the whole genomes of five individuals in each of three different hunter-gatherer populations at > 60× coverage: Pygmies from Cameroon and Khoesan-speaking Hadza and Sandawe from Tanzania. We identify 13.4 million variants, substantially increasing the set of known human variation. We found evidence of archaic introgression in all three populations, and the distribution of time to most recent common ancestors from these regions is similar to that observed for introgressed regions in Europeans. Additionally, we identify numerous loci that harbor signatures of local adaptation, including genes involved in immunity, metabolism, olfactory and taste perception, reproduction, and wound healing. Within the Pygmy population, we identify multiple highly differentiated loci that play a role in growth and anterior pituitary function and are associated with height.
Subject:
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Blacks
Evolution, Molecular
Genetics, Medical
Genome, Human
High-Throughput Nucleotide Sequencing
Human Activities
Humans
Polymorphism, Single Nucleotide
Sequence Analysis, DNA

Source:
Cell. 2012 ; 150(3):457-469;
Pubmed ID:
22840920
Pubmed Central ID:
PMC3426505
Document Type:
Journal Article ;
Funding:
R01GM076637/GM/NIGMS NIH HHS/United States ; 8 DP1 ES022557-04/DP/NCCDPHP CDC HHS/United States ; R01 GM076637/GM/NIGMS NIH HHS/United States ; P30-ES013508-07/ES/NIEHS NIH HHS/United States ; P30 ES013508/ES/NIEHS NIH HHS/United States ; ... More +
R01GM076637/GM/NIGMS NIH HHS/United States ; 8 DP1 ES022557-04/DP/NCCDPHP CDC HHS/United States ; R01 GM076637/GM/NIGMS NIH HHS/United States ; P30-ES013508-07/ES/NIEHS NIH HHS/United States ; P30 ES013508/ES/NIEHS NIH HHS/United States ; F32HG006648-01/HG/NHGRI NIH HHS/United States ; F32 HG006648/HG/NHGRI NIH HHS/United States ; DP1 ES022577/ES/NIEHS NIH HHS/United States ; Less -
Place as Subject:
Africa ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:7b07263b5646af77ca1a6f19461ca9130e759243b34ef2c55f17b68041c9783e
File Type:

Supporting Files

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  	NIHMS398077-supplement-01.pdf	pdf
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