Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bright, A. Taylor ; Alenazi, Thamer ; Shokoples, Sandra ; Tarning, Joel ; Paganotti, Giacomo M. ; ... More +
Bright, A. Taylor ; Alenazi, Thamer ; Shokoples, Sandra ; Tarning, Joel ; Paganotti, Giacomo M. ; White, Nicholas J. ; Houston, Stanley ; Winzeler, Elizabeth A. ; Yanow, Stephanie K. Less -
Description:
Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
Subject:
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Adult
Antimalarials
Biotransformation
Chloroquine
Drug Tolerance
Genome, Protozoan
High-Throughput Nucleotide Sequencing
Humans
Malaria, Vivax
Male
Polymorphism, Single Nucleotide
Primaquine
Recurrence
Sequence Analysis, DNA

Source:
Emerg Infect Dis. 19(5):802-805.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:6842e624c3f7427d0c8e5ad06cdd67131d372529572c7f1cfb94e27a54142cb1
File Type:

Supporting Files

• 	12-1852-Techapp-s1.pdf	pdf
  	12-1852.nxml	txt
  	license.txt	txt

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