Genetic Analysis of Primaquine Tolerance in a Patient with Relapsing Vivax Malaria

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Bright, A. Taylor ; Alenazi, Thamer ; Shokoples, Sandra ; Tarning, Joel ; Paganotti, Giacomo M. ; White, Nicholas J. ; Houston, Stanley ; Winzeler, Elizabeth A. ; Yanow, Stephanie K.
• Description:
  Patients with Plasmodium vivax malaria are treated with primaquine to prevent relapse infections. We report primaquine failure in a patient with 3 relapses without any possibility of re-infection. Using whole genome sequencing of the relapsing parasite isolates, we identified single nucleotide variants as candidate molecular markers of resistance.
• Subjects:
  Adult Antimalarials Biotransformation Chloroquine Drug Tolerance Genome, Protozoan High-Throughput Nucleotide Sequencing Humans Malaria, Vivax Male Polymorphism, Single Nucleotide Primaquine Recurrence Sequence Analysis, DNA

  More +
• Source:
  Emerg Infect Dis. 19(5):802-805.
• Document Type:
  Journal Article
• Volume:
  19
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6842e624c3f7427d0c8e5ad06cdd67131d372529572c7f1cfb94e27a54142cb1
• Download URL:
  https://stacks.cdc.gov/view/cdc/19044/cdc_19044_DS1.pdf
• File Type:
  [PDF - 2.06 MB ]