Immunological and Inflammatory Responses to Organic Dust in Agriculture

Details

• Alternative Title:
  Curr Opin Allergy Clin Immunol
• Personal Author:
  Poole, Jill A. ; Romberger, Debra J.
• Description:
  Purpose of review
  
  Agriculture represents a major industry worldwide, and despite protection against the development of IgE-mediated diseases, chronic exposure to agriculture-related organic dusts is associated with an increased risk of developing respiratory disease. This article will review the literature regarding new knowledge of important etiologic agents in the dusts and focus on the immunologic responses following acute and repetitive organic dust exposures.
  
  Recent findings
  
  Although endotoxin remains important, there is an emerging role for non-endotoxin components such as peptidoglycans from Gram-positive bacteria. Pattern recognition receptors including Toll-like receptor 4 (TLR4), TLR2 and intracellular nucleotide oligomerization domain-like receptors are partially responsible for mediating the inflammatory consequences. Repeated organic dust exposures modulate innate and adaptive immune function with a resultant adaptation-like response. However, repetitive exposures cause lung parenchymal inflammation, chronic disease, and lung function decline over time.
  
  Summary
  
  The immunological consequences of organic dust exposure in the farming industry are likely explained by the diversity of microbial motifs in dust that can elicit differing innate immune receptor signaling pathways. Whereas initial activation results in a robust inflammatory response, repetitive dust exposures modulate immunity. This can result in low-grade, chronic inflammation and/or protection against allergic disease.
  
  
• Subjects:
  Agricultural Workers' Diseases Animals Chronic Disease Dust Endotoxins Female General Adaptation Syndrome Humans Immunoglobulin E Male Mice Occupational Exposure Pneumonia Receptors, Pattern Recognition

  More +
• Source:
  Curr Opin Allergy Clin Immunol. 12(2):126-132.
• Pubmed ID:
  22306554
• Pubmed Central ID:
  PMC3292674
• Document Type:
  Journal Article
• Funding:
  1 U54 OH010162-01/OH/NIOSH CDC HHS/United States ; ES015522-03S1/ES/NIEHS NIH HHS/United States ; K08 ES015522/ES/NIEHS NIH HHS/United States ; K08 ES015522-01/ES/NIEHS NIH HHS/United States ; K08 ES015522-05/ES/NIEHS NIH HHS/United States ; R01 ES019325/ES/NIEHS NIH HHS/United States ; R01 ES019325-02/ES/NIEHS NIH HHS/United States ; R01 OH008539-01/OH/NIOSH CDC HHS/United States
• Volume:
  12
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:5bd0a9e8f0ad9c0472f070488dbf0b0b5d3483220cf4150fde2a14ebb0aa29a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/33315/cdc_33315_DS1.pdf
• File Type:
  [PDF - 635.66 KB ]