Details:

Alternative Title:
Pediatr Infect Dis J
Personal Author:
Prill, Mila M. ; Iwane, Marika K. ; Edwards, Kathryn M. ; Williams, John V. ; Weinberg, Geoffrey A. ; ... More +
Prill, Mila M. ; Iwane, Marika K. ; Edwards, Kathryn M. ; Williams, John V. ; Weinberg, Geoffrey A. ; Staat, Mary A. ; Willby, Melisa J. ; Talbot, H. Keipp ; Hall, Caroline B. ; Szilagyi, Peter G. ; Griffin, Marie R. ; Curns, Aaron T. ; Erdman, Dean D. ; Less -
Corporate Authors:
for the New Vaccine Surveillance Network ;
Description:
Background Human coronaviruses (HCoVs) have been detected in children with upper and lower respiratory symptoms but little is known about their relationship with severe respiratory illness. Objective To compare the prevalence of HCoV species among children hospitalized for acute respiratory illness and/or fever with asymptomatic controls and to assess the severity of outcomes among hospitalized children with HCoV compared with other respiratory viruses. Methods From December 2003–April 2004 and October 2004–April 2005, we conducted prospective, population-based surveillance of children <5 years of age hospitalized for ARI/fever in three U.S. counties. Asymptomatic outpatient controls were enrolled concurrently. Nasal/throat swabs were tested for HCoV species HKU1, NL63, 229E, and OC43 by RT-PCR. Specimens from hospitalized children were also tested for other common respiratory viruses. Demographic and medical data were collected by parent/guardian interview and medical chart review. Results Overall, HCoV was detected in 113 (7.6%) of 1,481 hospitalized children (83 [5.7%] after excluding 30 cases coinfected with other viruses) and 53 (7.1%) of 742 controls. The prevalence of HCoV or individual species was not significantly higher among hospitalized children than controls. Hospitalized children testing positive for HCoV alone tended to be less ill than those infected with other viruses, while those coinfected with HCoV and other viruses were clinically similar to those infected with other viruses alone. Conclusion In this study of children hospitalized for acute respiratory illness and/or fever, HCoV infection was not associated with hospitalization or with increased severity of illness.
Subject:
[+]
Article
Child, Preschool
Coronavirus
Coronavirus Infections
Female
Hospitalization
Humans
Infant
Infant, Newborn
Male
Nose
Pharynx
Prevalence
Prospective Studies
Real-Time Polymerase Chain Reaction
Respiratory Tract Infections
Severity Of Illness Index
Treatment Outcome

Source:
Pediatr Infect Dis J. 31(3):235-240
Pubmed ID:
22094637
Pubmed Central ID:
PMC3288315
Document Type:
Journal Article ;
Funding:
U01 IP000147/IP/NCIRD CDC HHS/United States ; U38/CCU417958/PHS HHS/United States ; U01/IP000147/IP/NCIRD CDC HHS/United States ; N01 AI025462/AI/NIAID NIH HHS/United States ; K23 AI074863/AI/NIAID NIH HHS/United States ; ... More +
U01 IP000147/IP/NCIRD CDC HHS/United States ; U38/CCU417958/PHS HHS/United States ; U01/IP000147/IP/NCIRD CDC HHS/United States ; N01 AI025462/AI/NIAID NIH HHS/United States ; K23 AI074863/AI/NIAID NIH HHS/United States ; U38/CCU217969/PHS HHS/United States ; U01/IP000022/IP/NCIRD CDC HHS/United States ; R03 AI068069/AI/NIAID NIH HHS/United States ; N01AI25462/AI/NIAID NIH HHS/United States ; 1K23AI074863-01/AI/NIAID NIH HHS/United States ; U01 IP000022/IP/NCIRD CDC HHS/United States ; U01/IP000017/IP/NCIRD CDC HHS/United States ; U38/CCU522352/PHS HHS/United States ; K23 AI074863-01A1/AI/NIAID NIH HHS/United States ; U01 IP000017/IP/NCIRD CDC HHS/United States ; Less -
Place as Subject:
United States ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:bb864b2dd3163499b2dcb6b0a328476409850c6f17b0257e438146dc315b8521
File Type:

Supporting Files

• 	NIHMS339775-supplement-01.pdf	pdf
  	nihms339775.nxml	xml

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