Human Coronavirus in Young Children Hospitalized for Acute Respiratory Illness and Asymptomatic Controls

Details

• Alternative Title:
  Pediatr Infect Dis J
• Personal Author:
  Prill, Mila M. ; Iwane, Marika K. ; Edwards, Kathryn M. ; Williams, John V. ; Weinberg, Geoffrey A. ; Staat, Mary A. ; Willby, Melisa J. ; Talbot, H. Keipp ; Hall, Caroline B. ; Szilagyi, Peter G. ; Griffin, Marie R. ; Curns, Aaron T. ; Erdman, Dean D.
• Corporate Authors:
  for the New Vaccine Surveillance Network
• Description:
  Background
  
  Human coronaviruses (HCoVs) have been detected in children with upper and lower respiratory symptoms but little is known about their relationship with severe respiratory illness.
  
  Objective
  
  To compare the prevalence of HCoV species among children hospitalized for acute respiratory illness and/or fever with asymptomatic controls and to assess the severity of outcomes among hospitalized children with HCoV compared with other respiratory viruses.
  
  Methods
  
  From December 2003–April 2004 and October 2004–April 2005, we conducted prospective, population-based surveillance of children <5 years of age hospitalized for ARI/fever in three U.S. counties. Asymptomatic outpatient controls were enrolled concurrently. Nasal/throat swabs were tested for HCoV species HKU1, NL63, 229E, and OC43 by RT-PCR. Specimens from hospitalized children were also tested for other common respiratory viruses. Demographic and medical data were collected by parent/guardian interview and medical chart review.
  
  Results
  
  Overall, HCoV was detected in 113 (7.6%) of 1,481 hospitalized children (83 [5.7%] after excluding 30 cases coinfected with other viruses) and 53 (7.1%) of 742 controls. The prevalence of HCoV or individual species was not significantly higher among hospitalized children than controls. Hospitalized children testing positive for HCoV alone tended to be less ill than those infected with other viruses, while those coinfected with HCoV and other viruses were clinically similar to those infected with other viruses alone.
  
  Conclusion
  
  In this study of children hospitalized for acute respiratory illness and/or fever, HCoV infection was not associated with hospitalization or with increased severity of illness.
  
  
• Subjects:
  Article Child, Preschool Coronavirus Coronavirus Infections Female Hospitalization Humans Infant Infant, Newborn Male Nose Pharynx Prevalence Prospective Studies Real-Time Polymerase Chain Reaction Respiratory Tract Infections Severity Of Illness Index Treatment Outcome

  More +
• Source:
  Pediatr Infect Dis J. 31(3):235-240
• Pubmed ID:
  22094637
• Pubmed Central ID:
  PMC3288315
• Document Type:
  Journal Article
• Funding:
  U01 IP000147/IP/NCIRD CDC HHS/United States ; U38/CCU417958/PHS HHS/United States ; U01/IP000147/IP/NCIRD CDC HHS/United States ; N01 AI025462/AI/NIAID NIH HHS/United States ; K23 AI074863/AI/NIAID NIH HHS/United States ; U38/CCU217969/PHS HHS/United States ; U01/IP000022/IP/NCIRD CDC HHS/United States ; R03 AI068069/AI/NIAID NIH HHS/United States ; N01AI25462/AI/NIAID NIH HHS/United States ; 1K23AI074863-01/AI/NIAID NIH HHS/United States ; U01 IP000022/IP/NCIRD CDC HHS/United States ; U01/IP000017/IP/NCIRD CDC HHS/United States ; U38/CCU522352/PHS HHS/United States ; K23 AI074863-01A1/AI/NIAID NIH HHS/United States ; U01 IP000017/IP/NCIRD CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  31
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:bb864b2dd3163499b2dcb6b0a328476409850c6f17b0257e438146dc315b8521
• Download URL:
  https://stacks.cdc.gov/view/cdc/33311/cdc_33311_DS1.pdf
• File Type:
  [PDF - 297.75 KB ]