Human Coronavirus in Young Children Hospitalized for Acute Respiratory Illness and Asymptomatic Controls

Prill, Mila M.; Iwane, Marika K.; Edwards, Kathryn M.; Williams, John V.; Weinberg, Geoffrey A.; Staat, Mary A.; Willby, Melisa J.; Talbot, H. Keipp; Hall, Caroline B.; Szilagyi, Peter G.; Griffin, Marie R.; Curns, Aaron T.; Erdman, Dean D.

doi:10.1097/INF.0b013e31823e07fe

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Human Coronavirus in Young Children Hospitalized for Acute Respiratory Illness and Asymptomatic Controls

Published Date:

Mar 2012

Publisher's site:

http://dx.doi.org/10.1097/INF.0b013e31823e07fe New Site Icon

Source:

Pediatr Infect Dis J. 31(3):235-240.

[PDF - 297.75 KB]

Details:

Personal Authors:

Prill, Mila M. ; Iwane, Marika K. ; Edwards, Kathryn M. ; Williams, John V. ; Weinberg, Geoffrey A. ; ... More ▼

Corporate Authors:

for the New Vaccine Surveillance Network

Keywords:

[+]

Pubmed ID:

22094637

Pubmed Central ID:

PMC3288315

Description:

Background

Human coronaviruses (HCoVs) have been detected in children with upper and lower respiratory symptoms but little is known about their relationship with severe respiratory illness.

Objective

To compare the prevalence of HCoV species among children hospitalized for acute respiratory illness and/or fever with asymptomatic controls and to assess the severity of outcomes among hospitalized children with HCoV compared with other respiratory viruses.

Methods

From December 2003–April 2004 and October 2004–April 2005, we conducted prospective, population-based surveillance of children <5 years of age hospitalized for ARI/fever in three U.S. counties. Asymptomatic outpatient controls were enrolled concurrently. Nasal/throat swabs were tested for HCoV species HKU1, NL63, 229E, and OC43 by RT-PCR. Specimens from hospitalized children were also tested for other common respiratory viruses. Demographic and medical data were collected by parent/guardian interview and medical chart review.

Results

Overall, HCoV was detected in 113 (7.6%) of 1,481 hospitalized children (83 [5.7%] after excluding 30 cases coinfected with other viruses) and 53 (7.1%) of 742 controls. The prevalence of HCoV or individual species was not significantly higher among hospitalized children than controls. Hospitalized children testing positive for HCoV alone tended to be less ill than those infected with other viruses, while those coinfected with HCoV and other viruses were clinically similar to those infected with other viruses alone.

Conclusion

In this study of children hospitalized for acute respiratory illness and/or fever, HCoV infection was not associated with hospitalization or with increased severity of illness.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1K23AI074863-01/AI/NIAID NIH HHS/United States
K23 AI074863/AI/NIAID NIH HHS/United States
K23 AI074863-01A1/AI/NIAID NIH HHS/United States
N01 AI-25462/AI/NIAID NIH HHS/United States
N01AI25462/AI/NIAID NIH HHS/United States
R03 AI068069/AI/NIAID NIH HHS/United States
U01/IP000017/IP/NCIRD CDC HHS/United States
U01/IP000022/IP/NCIRD CDC HHS/United States
U01/IP000147/IP/NCIRD CDC HHS/United States
U38/CCU217969/PHS HHS/United States
U38/CCU417958/PHS HHS/United States
U38/CCU522352/PHS HHS/United States

Supporting Files:

NIHMS339775-supplement-01.pdf	application/pdf
nihms339775.nxml	text/plain

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