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Structural characterization of human Uch37.
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Sep 26 2011
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Source: Proteins. 80(2):649-654
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Alternative Title:Proteins
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Description:Uch37 is a de-ubiquitylating enzyme that is functionally linked with the 26S proteasome via Rpn13, and is essential for metazoan development. Here, we report the X-ray crystal structure of full-length human Uch37 at 2.95 Å resolution. Uch37's catalytic domain is similar to those of all UCH enzymes characterized to date. The C-terminal extension is elongated, predominantly helical and contains coiled coil interactions. Additionally, we provide an initial characterization of Uch37's oligomeric state and identify a systematic error in previous analyses of Uch37 activity. Taken together, these data provide a strong foundation for further analysis of Uch37's several functions.
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Pubmed ID:21953935
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Pubmed Central ID:PMC3251636
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Volume:80
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Issue:2
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