Vaccines for mucosal immunity to combat emerging infectious diseases.

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  van Ginkel, F. W. ; Nguyen, H. H. ; McGhee, J. R.
• Description:
  The mucosal immune system consists of molecules, cells, and organized lymphoid structures intended to provide immunity to pathogens that impinge upon mucosal surfaces. Mucosal infection by intracellular pathogens results in the induction of cell- mediated immunity, as manifested by CD4-positive (CD4 + ) T helper-type 1 cells, as well as CD8 + cytotoxic T-lymphocytes. These responses are normally accompanied by the synthesis of secretory immunoglobulin A (S-IgA) antibodies, which provide an important first line of defense against invasion of deeper tissues by these pathogens. New-generation live, attenuated viral vaccines, such as the cold-adapted, recombinant nasal influenza and oral rotavirus vaccines, optimize this form of mucosal immune protection. Despite these advances, new and reemerging infectious diseases are tipping the balance in favor of the parasite; continued mucosal vaccine development will be needed to effectively combat these new threats.
• Subjects:
  B-Lymphocytes Communicable Disease Control Cytokines Humans Immunity, Cellular Immunity, Mucosal Immunoglobulin A, Secretory T-Lymphocytes T-Lymphocytes, Cytotoxic Vaccines
• Source:
  Emerg Infect Dis. 6(2):123-132.
• Document Type:
  Journal Article
• Volume:
  6
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:c5033a65075684e5e28712c02bd865c0e85855e7322869da6923e6c110535f53
• Download URL:
  https://stacks.cdc.gov/view/cdc/14956/cdc_14956_DS1.pdf
• File Type:
  [PDF - 222.61 KB ]