Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
van Ginkel, F. W. ; Nguyen, H. H. ; McGhee, J. R.
van Ginkel, F. W. ; Nguyen, H. H. ; McGhee, J. R. Less -
Description:
The mucosal immune system consists of molecules, cells, and organized lymphoid structures intended to provide immunity to pathogens that impinge upon mucosal surfaces. Mucosal infection by intracellular pathogens results in the induction of cell- mediated immunity, as manifested by CD4-positive (CD4 + ) T helper-type 1 cells, as well as CD8 + cytotoxic T-lymphocytes. These responses are normally accompanied by the synthesis of secretory immunoglobulin A (S-IgA) antibodies, which provide an important first line of defense against invasion of deeper tissues by these pathogens. New-generation live, attenuated viral vaccines, such as the cold-adapted, recombinant nasal influenza and oral rotavirus vaccines, optimize this form of mucosal immune protection. Despite these advances, new and reemerging infectious diseases are tipping the balance in favor of the parasite; continued mucosal vaccine development will be needed to effectively combat these new threats.
Subject:
[+]
B-Lymphocytes
Communicable Disease Control
Cytokines
Humans
Immunity, Cellular
Immunity, Mucosal
Immunoglobulin A, Secretory
T-Lymphocytes
T-Lymphocytes, Cytotoxic
Vaccines

Source:
Emerg Infect Dis. 6(2):123-132.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:c5033a65075684e5e28712c02bd865c0e85855e7322869da6923e6c110535f53
File Type:

Supporting Files

• 	10756145.nxml	txt
  	license.txt	txt

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