Lack of evidence of endogenous avian leukosis virus and endogenous avian retrovirus transmission to measles, mumps, and rubella vaccine recipients.

Hussain, Althaf I.; Shanmugam, Vedapuri.; Switzer, William M.; Tsang, Shirley X.; Fadly, Aly.; Thea, Donald.; Helfand, Rita.; Bellini, William. J.; Folks, Thomas M.; Heneine, Walid.

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Lack of evidence of endogenous avian leukosis virus and endogenous avian retrovirus transmission to measles, mumps, and rubella vaccine recipients.

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2001 Jan-Feb
By Hussain, Althaf I. ; Shanmugam, Vedapuri. ; Switzer, William M. ; ...

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Hussain, Althaf I. ; Shanmugam, Vedapuri. ; Switzer, William M. ; Tsang, Shirley X. ; Fadly, Aly. ; Thea, Donald. ; Helfand, Rita. ; Bellini, William. J. ; Folks, Thomas M. ; Heneine, Walid.
Description:

The identification of endogenous avian leukosis virus (ALV) and endogenous avian retrovirus (EAV) in chick cell-derived measles and mumps vaccines in current use has raised concern about transmission of these retroviruses to vaccine recipients. We used serologic and molecular methods to analyze specimens from 206 recipients of measles, mumps, and rubella (MMR) vaccine for evidence of infection with ALV and EAV. A Western blot assay for detecting antibodies to endogenous ALV was developed and validated. All serum samples were negative for antibodies to endogenous ALV by Western blot analysis. Peripheral blood lymphocyte samples from 100 vaccinees were further tested by polymerase chain reaction for both ALV and EAV proviral sequences; all were negative. Matching serum samples were tested by reverse transcriptase polymerase chain reaction for ALV and EAV RNA, and all 100 samples were negative, providing no evidence of viremia. These findings do not indicate the presence of either ALV or EAV infection in MMR vaccine recipients and provide support for current immunization policies.
Subjects:

Animals Avian Leukosis Virus Blotting, Western Chickens Child Endogenous Retroviruses Humans Measles-Mumps-Rubella Vaccine Research Article Retroviridae Infections
Source:

Emerg Infect Dis. 7(1):66-72.
Document Type:

Journal Article
Volume:

7
Issue:

1
Collection(s):

Emerging Infectious Diseases
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urn:sha256:9ff8a3b74e911d23305566b835d2cd587114fe5d1006a6f10bd0c8ac0076def4
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