Genetic polymorphisms modify bladder cancer recurrence and survival in a U.S. population-based prognostic study
Published Date:Mar 26 2014
Source:BJU Int. 115(2):238-247.
Carcinoma, Transitional Cell
Molecular Targeted Therapy
Neoplasm Recurrence, Local
Polymorphism, Single Nucleotide
Urinary Bladder Neoplasms
Vascular Cell Adhesion Molecule-1
Pubmed Central ID:PMC4533837
Funding:5 P42 ES05947/ES/NIEHS NIH HHS/United States
5P20RR024475-02/RR/NCRR NIH HHS/United States
8P20GM103534-02/GM/NIGMS NIH HHS/United States
CA078609/CA/NCI NIH HHS/United States
CA099500/CA/NCI NIH HHS/United States
CA102327/CA/NCI NIH HHS/United States
CA121382/CA/NCI NIH HHS/United States
CA57494/CA/NCI NIH HHS/United States
CA82354/CA/NCI NIH HHS/United States
ES00002/ES/NIEHS NIH HHS/United States
ES07373/ES/NIEHS NIH HHS/United States
K07 CA102327/CA/NCI NIH HHS/United States
LM009012/LM/NLM NIH HHS/United States
P20 GM103534/GM/NIGMS NIH HHS/United States
P20 RR024475/RR/NCRR NIH HHS/United States
P30 CA023108/CA/NCI NIH HHS/United States
P30 ES000002/ES/NIEHS NIH HHS/United States
R01 LM009012/LM/NLM NIH HHS/United States
R03 CA121382/CA/NCI NIH HHS/United States
R21 CA182659/CA/NCI NIH HHS/United States
RR018787/RR/NCRR NIH HHS/United States
RR028309/RR/NCRR NIH HHS/United States
U58/DP000798/DP/NCCDPHP CDC HHS/United States
To identify genetic variants that modify bladder cancer prognosis focusing on genes involved in major biological carcinogenesis processes (apoptosis, proliferation, DNA repair, hormone regulation, immune surveillance, and cellular metabolism).
Subjects and methods
We analyzed variant genotypes hypothesized to modify these processes in 563 urothelial-cell carcinoma cases enrolled in a population-based study of incident bladder cancer conducted in New Hampshire, U.S.A.
Aldehyde dehydrogenase 2 (ALDH2) variants had shorter time to first bladder cancer recurrence (adjusted non-invasive HR 1.90 95%CI 1.29-2.78).
Our analysis suggests candidate prognostic SNPs that could guide personalized bladder cancer surveillance and treatment.
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