Genetic polymorphisms modify bladder cancer recurrence and survival in a U.S. population-based prognostic study

Details

• Alternative Title:
  BJU Int
• Personal Author:
  Andrew, Angeline S. ; Gui, Jiang ; Hu, Ting ; Wyszynski, Asaf ; Marsit, Carmen J. ; Kelsey, Karl T. ; Schned, Alan R. ; Tanyos, Sam A. ; Pendleton, Eben M. ; Ekstrom, Rebecca M. ; Li, Zhongze ; Zens, Michael S. ; Borsuk, Mark ; Moore, Jason H. ; Karagas, Margaret R.
• Description:
  Objective
  
  To identify genetic variants that modify bladder cancer prognosis focusing on genes involved in major biological carcinogenesis processes (apoptosis, proliferation, DNA repair, hormone regulation, immune surveillance, and cellular metabolism).
  
  Subjects and methods
  
  We analyzed variant genotypes hypothesized to modify these processes in 563 urothelial-cell carcinoma cases enrolled in a population-based study of incident bladder cancer conducted in New Hampshire, U.S.A.
  
  Results
  
  Aldehyde dehydrogenase 2 (ALDH2) variants had shorter time to first bladder cancer recurrence (adjusted non-invasive HR 1.90 95%CI 1.29-2.78).
  
  Conclusion
  
  Our analysis suggests candidate prognostic SNPs that could guide personalized bladder cancer surveillance and treatment.
  
  
• Subjects:
  Adult Aged Aldehyde Dehydrogenase Aldehyde Dehydrogenase, Mitochondrial Antineoplastic Agents Carcinoma, Transitional Cell DNA-Binding Proteins DNA Repair Female Genetic Variation Genotype Humans Male Middle Aged Molecular Targeted Therapy Neoplasm Recurrence, Local Neoplasm Staging Polymorphism, Single Nucleotide Precision Medicine Prognosis Survival Analysis Urinary Bladder Neoplasms Vascular Cell Adhesion Molecule-1

  More +
• Keywords:
  Bladder Cancer DNA Repair Immune Polymorphism Prognosis Recurrence Survival
• Source:
  BJU Int. 115(2):238-247
• Pubmed ID:
  24666523
• Pubmed Central ID:
  PMC4533837
• Document Type:
  Journal Article
• Funding:
  ES00002/ES/NIEHS NIH HHSUnited States/ ; CA82354/CA/NCI NIH HHSUnited States/ ; CA121382/CA/NCI NIH HHSUnited States/ ; P30 ES000002/ES/NIEHS NIH HHSUnited States/ ; P30 CA023108/CA/NCI NIH HHSUnited States/ ; P42 ES005947/ES/NIEHS NIH HHSUnited States/ ; K07 CA102327/CA/NCI NIH HHSUnited States/ ; U58/DP000798/DP/NCCDPHP CDC HHSUnited States/ ; R21 CA182659/CA/NCI NIH HHSUnited States/ ; R01 LM009012/LM/NLM NIH HHSUnited States/ ; CA099500/CA/NCI NIH HHSUnited States/ ; R01 CA082354/CA/NCI NIH HHSUnited States/ ; P20 RR024475/RR/NCRR NIH HHSUnited States/ ; LM009012/LM/NLM NIH HHSUnited States/ ; 8P20GM103534-02/GM/NIGMS NIH HHSUnited States/ ; R01 CA057494/CA/NCI NIH HHSUnited States/ ; P20 GM103534/GM/NIGMS NIH HHSUnited States/ ; ES07373/ES/NIEHS NIH HHSUnited States/ ; 5 P42 ES05947/ES/NIEHS NIH HHSUnited States/ ; P42 ES007373/ES/NIEHS NIH HHSUnited States/ ; U58 DP000798/DP/NCCDPHP CDC HHSUnited States/ ; P20 RR018787/RR/NCRR NIH HHSUnited States/ ; 5P20RR024475-02/RR/NCRR NIH HHSUnited States/ ; R03 CA099500/CA/NCI NIH HHSUnited States/ ; R01 CA078609/CA/NCI NIH HHSUnited States/ ; RR028309/RR/NCRR NIH HHSUnited States/ ; CA102327/CA/NCI NIH HHSUnited States/ ; R03 CA121382/CA/NCI NIH HHSUnited States/ ; CA078609/CA/NCI NIH HHSUnited States/ ; RR018787/RR/NCRR NIH HHSUnited States/ ; CA57494/CA/NCI NIH HHSUnited States/
• Volume:
  115
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e8342650d366ef67e3efdbcdcdc1d97f772dfeb1cb85390f108a138afabecd4d
• Download URL:
  https://stacks.cdc.gov/view/cdc/32852/cdc_32852_DS1.pdf
• File Type:
  [PDF - 561.42 KB ]