Large-scale recording of astrocyte activity

Details

• Alternative Title:
  Curr Opin Neurobiol
• Personal Author:
  Nimmerjahn, Axel ; Bergles, Dwight E.
• Description:
  Astrocytes are highly ramified glial cells found throughout the central nervous system (CNS). They express a variety of neurotransmitter receptors that can induce widespread chemical excitation, placing these cells in an optimal position to exert global effects on brain physiology. However, the activity patterns of only a small fraction of astrocytes have been examined and techniques to manipulate their behavior are limited. As a result, little is known about how astrocytes modulate CNS function on synaptic, microcircuit, or systems levels. Here, we review current and emerging approaches for visualizing and manipulating astrocyte activity in vivo. Deciphering how astrocyte network activity is controlled in different physiological and pathological contexts is crucial for defining their roles in the healthy and diseased CNS.
• Subjects:
  Animals Article Astrocytes Central Nervous System Humans Nerve Net Signal Transduction
• Source:
  Curr Opin Neurobiol. 2015; 32:95-106.
• Pubmed ID:
  25665733
• Pubmed Central ID:
  PMC4447573
• Document Type:
  Journal Article
• Funding:
  1DP2NS083038/DP/NCCDPHP CDC HHS/United States ; 5P30NS050274/NS/NINDS NIH HHS/United States ; 5P50MH100024/MH/NIMH NIH HHS/United States ; 5R01NS085938/NS/NINDS NIH HHS/United States ; 5T32EY017203/EY/NEI NIH HHS/United States ; DP2 NS083038/NS/NINDS NIH HHS/United States ; P50 MH100024/MH/NIMH NIH HHS/United States ; R01 NS085938/NS/NINDS NIH HHS/United States
• Volume:
  32
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f80b9b7f9cc3b3b6da8717f331a013efe0d018ac47033aa0538117de4af573f9
• Download URL:
  https://stacks.cdc.gov/view/cdc/32314/cdc_32314_DS1.pdf
• File Type:
  [PDF - 702.12 KB ]