Large-scale recording of astrocyte activity

Nimmerjahn, Axel; Bergles, Dwight E.

doi:10.1016/j.conb.2015.01.015

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Large-scale recording of astrocyte activity

Published Date:

Feb 06 2015

Publisher's site:

http://dx.doi.org/10.1016/j.conb.2015.01.015 New Site Icon

Source:

Curr Opin Neurobiol. 2015; 32:95-106.

[PDF-702.12 KB]

Details:

Personal Authors:

Nimmerjahn, Axel ; Bergles, Dwight E. ;

Keywords:

[+]

Pubmed ID:

25665733

Pubmed Central ID:

PMC4447573

Description:

Astrocytes are highly ramified glial cells found throughout the central nervous system (CNS). They express a variety of neurotransmitter receptors that can induce widespread chemical excitation, placing these cells in an optimal position to exert global effects on brain physiology. However, the activity patterns of only a small fraction of astrocytes have been examined and techniques to manipulate their behavior are limited. As a result, little is known about how astrocytes modulate CNS function on synaptic, microcircuit, or systems levels. Here, we review current and emerging approaches for visualizing and manipulating astrocyte activity in vivo. Deciphering how astrocyte network activity is controlled in different physiological and pathological contexts is crucial for defining their roles in the healthy and diseased CNS.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

1DP2NS083038/DP/NCCDPHP CDC HHS/United States
5P30NS050274/NS/NINDS NIH HHS/United States
5P50MH100024/MH/NIMH NIH HHS/United States
5R01NS085938/NS/NINDS NIH HHS/United States
5T32EY017203/EY/NEI NIH HHS/United States
DP2 NS083038/NS/NINDS NIH HHS/United States
P50 MH100024/MH/NIMH NIH HHS/United States
R01 NS085938/NS/NINDS NIH HHS/United States

Supporting Files:

	nihms-662361-f0001.gif	image/gif
	nihms-662361-f0001.jpg	image/jpeg
	nihms-662361-f0002.gif	image/gif
	nihms-662361-f0002.jpg	image/jpeg
	nihms-662361.nxml	application/octet-stream

No Related Documents.

You May Also Like:

Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq

Personal Author:

Cadwell, Cathryn R; Palasantza, Athanasia; Jiang, Xiaolong; Berens, Philipp; Deng, Qiaolin; Yilmaz, Marlene; Reimer, Jacob; Shen, Shan; Bethge, Matthias; Tolias, Kimberley F; Sandberg, Rickard; Tolias, Andreas S;

Published:

Dec 21 2015

Source:

Nat Biotechnol. 34(2):199-203.

Description:

Despite the importance of the mammalian neocortex for complex cognitive processes, we still lack a comprehensive description of its cellular components. To improve the classification of neuronal cell types and the functional characterization of singl...

File Type:

[PDF - 558.26 KB]
Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits

Personal Author:

Sun, Ying; Liou, Benjamin; Ran, Huimin; Skelton, Matthew R.; Williams, Michael T.; Vorhees, Charles V.; Kitatani, Kazuyuki; Hannun, Yusuf A.; Witte, David P.; Xu, You-Hai; Grabowski, Gregory A.;

Published:

Jan 04 2010

Source:

Hum Mol Genet. 19(6):1088-1097.

Description:

Gaucher disease is caused by defective acid beta-glucosidase (GCase) function. Saposin C is a lysosomal protein needed for optimal GCase activity. To test the in vivo effects of saposin C on GCase, saposin C deficient mice (C-/-) were backcrossed to ...

File Type:

[PDF - 561.94 KB]
TAM receptors regulate multiple features of microglial physiology

Personal Author:

Fourgeaud, Lawrence; Través, Paqui G.; Tufail, Yusuf; Leal-Bailey, Humberto; Lew, Erin D.; Burrola, Patrick G.; Callaway, Perri; Zagórska, Anna; Rothlin, Carla V.; Nimmerjahn, Axel; Lemke, Greg;

Published:

Apr 06 2016

Source:

Nature. 532(7598):240-244.

Description:

Microglia are damage sensors for the central nervous system (CNS), and the phagocytes responsible for routine non-inflammatory clearance of dead brain cells. Here we show that the TAM receptor tyrosine kinases Mer and Axl regulate these microglial fu...

File Type:

[PDF - 2.99 MB]
Interrogating cellular fate decisions with high-throughput arrays of multiplexed cellular communities

Personal Author:

Chen, Sisi; Bremer, Andrew W.; Scheideler, Olivia J.; Na, Yun Suk; Todhunter, Michael E.; Hsiao, Sonny; Bomdica, Prithvi R.; Maharbiz, Michel M.; Gartner, Zev J.; Schaffer, David V.;

Published:

Jan 12 2016

Source:

Nat Commun. 2016; 7.

Description:

Recreating heterotypic cell-cell interactions in vitro is key to dissecting the role of cellular communication during a variety of biological processes. This is especially relevant for stem cell niches, where neighbouring cells provide instructive in...

File Type:

[PDF - 2.13 MB]
Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts Type of article: research article

Personal Author:

Tsytsarev, Vassiliy; Rao, Bin; Maslov, Konstantin I.; Li, Li; Wang, Lihong V.;

Published:

Apr 17 2013

Source:

J Neurosci Methods. 2013; 216(2):142-145.

Description:

Epilepsy mapping with high spatial and temporal resolution has great significance for both fundamental research on epileptic neurons and the clinical management of epilepsy. In this communication, we demonstrate for the first time in vivo epilepsy ma...

File Type:

[PDF - 305.61 KB]