Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species.

Details

• Alternative Title:
  Environ Health Perspect
• Personal Author:
  Chen, Fei ; Shi, Xianglin
• Description:
  The nuclear factor kappa B (NF-kappaB) family of transcription factors controls expression of a number of early response genes associated with inflammatory responses, cell growth, cell cycle progression, and neoplastic transformation. These genes include a multitude of cytokines, chemokines, adhesion molecules, immune receptors, stress proteins, apoptotic or anti-apoptotic regulators, and several oncogenes. Accumulating evidence indicates that a variety of toxic metals are able to affect the activation or activity of NF-kappaB, but the molecular mechanisms involved in this process remain largely unknown. The signaling pathways mediating cytokine- or microorganism-induced NF-kappaB activation have been well established recently. Whether the same signaling systems are involved in metal-induced NF-kappaB activation, however, is unclear. In the present review, we have attempted to evaluate and update the possible mechanisms of metal signals on the activation and function of NF-kappaB.
• Subjects:
  Cytokines Gene Expression Regulation Humans Metals, Heavy NF-kappa B Oxidative Stress Phosphotransferases Reactive Oxygen Species Signal Transduction
• Source:
  Environ Health Perspect. 110(Suppl 5):807-811.
• Document Type:
  Journal Article
• Volume:
  110
• NIOSHTIC Number:
  nn:20022253
• Collection(s):
  CDC Public Access National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a40d5236fb7eb1f165391ff0d3f86a360ad688202e532b7098e996617b95fd5054744f2e08c556f3750bba18ab9e367fa6c52d87e5f96146b96a9400af026630
• Download URL:
  https://stacks.cdc.gov/view/cdc/3919/cdc_3919_DS1.pdf
• File Type:
  [PDF - 158.03 KB ]