Details:

Alternative Title:
Environ Health Perspect
Personal Author:
Chen, Fei ; Shi, Xianglin
Chen, Fei ; Shi, Xianglin Less -
Description:
The nuclear factor kappa B (NF-kappaB) family of transcription factors controls expression of a number of early response genes associated with inflammatory responses, cell growth, cell cycle progression, and neoplastic transformation. These genes include a multitude of cytokines, chemokines, adhesion molecules, immune receptors, stress proteins, apoptotic or anti-apoptotic regulators, and several oncogenes. Accumulating evidence indicates that a variety of toxic metals are able to affect the activation or activity of NF-kappaB, but the molecular mechanisms involved in this process remain largely unknown. The signaling pathways mediating cytokine- or microorganism-induced NF-kappaB activation have been well established recently. Whether the same signaling systems are involved in metal-induced NF-kappaB activation, however, is unclear. In the present review, we have attempted to evaluate and update the possible mechanisms of metal signals on the activation and function of NF-kappaB.
Subject:
[+]
Cytokines
Gene Expression Regulation
Humans
Metals, Heavy
NF-kappa B
Oxidative Stress
Phosphotransferases
Reactive Oxygen Species
Research Article
Signal Transduction

Source:
Environ Health Perspect. 110(Suppl 5):807-811.
Document Type:
Journal Article
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:57f6942c7511f7876024ac68e3a2e443f03aeb9cb499985ce67abe55f6a2c2a0
File Type:

Supporting Files

• 	ehp110s-000807.nxml	txt
  	license.txt	txt

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