Effects of Microgravity and Bone Morphogenetic Protein II on GFAP in Rat Brain

Details

• Personal Author:
  Day JR ; DeHart BW ; Frank AT ; O'Callaghan JP
• Description:
  This study evaluated effects of bone morphogenetic protein II (BMP) on glial fibrillary acidic protein (GFAP) in the brain of female Fischer 344 rats during 14 days of spaceflight. GFAP mRNA decreased in vehicle-implanted rats flown on the space shuttle by 53 and 48% in the stratum moleculare and stratum lacunosum moleculare hippocampal subregions, respectively. GFAP mRNA was not significantly affected by BMP implantation during spaceflight. Rats returning from space exhibited a 56% increase in serum corticosterone. BMP treatment did not additively increase corticosterone elevations in microgravity but appeared to increase serum corticosterone and reduce GFAP mRNA in the stratum moleculare in control rats. These data suggest that exposure to microgravity reduces GFAP expression in hippocampal astrocytes. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Nervous System Occupational Health Safety
• Keywords:
  Animal-studies Astrocytes Author Keywords: Hippocampus Brain-function Brain-matter Central-nervous-system Glial Fibrillary Acidic Protein Glucocorticoids Laboratory-animals Space-physiology Spaceflight Stress

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• ISSN:
  8750-7587
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  85
• Issue:
  2
• NIOSHTIC Number:
  nn:20024964
• Citation:
  J Appl Physiol 1998 Aug; 85(2):716-722
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Applied Physiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ff7abdbc7c93c8ee8ebedcac3ba5aabf80bec81e06c12bdc3e46a5c518fb649814877365ee52ca6160dac39b4dd61574dc10c0d27e20835c688b6400b24927c2
• Download URL:
  https://stacks.cdc.gov/view/cdc/196513/cdc_196513_DS1.pdf
• File Type:
  [PDF - 186.19 KB ]