Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Oberste, M. Steven; Gotuzzo, Eduardo; Blair, Patrick; Nix, W. Allan; Ksiazek, Thomas G.; Comer, James A.; Rollin, Pierre; Goldsmith, Cynthia S.; Olson, James; Kochel, Tadeusz J.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Published Date:

Apr 2009

Source:

Emerg Infect Dis. 15(4):640-646.

[PDF - 356.37 KB]

Details:

Personal Authors:

Oberste, M. Steven ; Gotuzzo, Eduardo ; Blair, Patrick ; Nix, W. Allan ; Ksiazek, Thomas G. ; ... More ▼

Keywords:

[+]

Description:

Etiologic studies of acute febrile disease were conducted in sites across South America, including Cusco and Iquitos, Peru. Patients' clinical signs and symptoms were recorded, and acute- and convalescent-phase serum samples were obtained for serologic examination and virus isolation in Vero E6 and C6/36 cells. Virus isolated in Vero E6 cells was identified as encephalomyocarditis virus (EMCV) by electron microscopy and by subsequent molecular diagnostic testing of samples from 2 febrile patients with nausea, headache, and dyspnea. The virus was recovered from acute-phase serum samples from both case-patients and identified with cardiovirus-specific reverse transcription-PCR and sequencing. Serum samples from case-patient 1 showed cardiovirus antibody by immunoglobulin M ELISA (acute phase <8, convalescent phase >1,024) and by neutralization assay (acute phase <10, convalescent phase >1,280). Serum samples from case-patient 2 did not contain antibodies detectable by either assay. Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness.

Document Type:

Journal Article

Collection(s):

CDC Public Access
Emerging Infectious Diseases

Supporting Files:

08-1428-F1.gif	image/gif
08-1428-F1.jpg	image/jpeg
08-1428-F2.gif	image/gif
08-1428-F2.jpg	image/jpeg
08-1428_finalR.nxml	text/plain
license.txt	text/plain

No Related Documents.

You May Also Like:

Itaya virus, a Novel Orthobunyavirus Associated with Human Febrile Illness, Peru

Personal Author:

Hontz, Robert D.; Guevara, Carolina; Halsey, Eric S.; Silvas, Jesus; Santiago, Felix W.; Widen, Steven G.; Wood, Thomas G.; Casanova, Wilma; Vasilakis, Nikos; Watts, Douglas M.; Kochel, Tadeusz J.; Ebihara, Hideki; Aguilar, Patricia V.;

Published:

May 2015

Source:

Emerg Infect Dis. 21(5):781-788.

Description:

Our genetic analyses of uncharacterized bunyaviruses isolated in Peru identified a possible reassortant virus containing small and large gene segment sequences closely related to the Caraparu virus and a medium gene segment sequence potentially deriv...

File Type:

[PDF - 1.89 MB]
Meningitis and a Febrile Vomiting illness Caused by Echovirus Type 4, Northern Territory, Australia

Personal Author:

Markey, Peter G.; Davis, Joshua S.; Harnett, Gerry B.; Williams, Simon H.; Speers, David J.;

Published:

Jan 2010

Source:

Emerg Infect Dis. 16(1):63-68.

Description:

In July 2007, a cluster of meningitis cases caused by an echovirus 4 strain was detected in 1 indigenous community in the Top End of the Northern Territory of Australia. Illness was characterized by fever, vomiting, and headache. Over the next 4 mont...

File Type:

[PDF - 318.35 KB]
Human Infection Caused by Leptospira fainei

Personal Author:

Arzouni, Jean-Pierre; Parola, Philippe; La Scola, Bernard; Postic, Danièle; Brouqui, Philippe; Raoult, Didier;

Published:

Aug 2002

Source:

Emerg Infect Dis. 8(8):865-868.

Description:

We report a human case of leptospirosis in which the spirochete was detected by dark-field microscopy examination of cerebrospinal fluid (CSF) and isolated from both CSF and blood. Leptospira fainei was identified by sequencing the 16S rDNA gene, whi...

File Type:

[PDF - 1.41 MB]
Human Infection Caused by Clostridium hathewayi

Personal Author:

Elsayed, Sameer; Zhang, Kunyan;

Published:

Nov 2004

Source:

Emerg Infect Dis. 10(11):1950-1952.

Description:

We describe a 27-year-old man with acute cholecystitis, hepatic abscess, and bacteremia caused by Clostridium hathewayi, a newly described gram-negative, endospore-forming, rod-shaped bacterium. This report is the first of human infection caused by t...

File Type:

[PDF - 347.53 KB]
Serologic evidence for hepatitis E virus infection among patients with undifferentiated acute febrile illness in Kibera, Kenya

Personal Author:

Furukawa, NW; Teshale, EH; Cosmas, L; Ochieng, M; Gikunju, S; Fields, BS; Montgomery, JM;

Published:

Feb 23 2016

Source:

J Clin Virol. 77:106-108.

Description:

Background : Hepatitis E (HEV) is an emerging cause of viral hepatitis mainly transmitted through the fecal-oral route. Residents of the Kibera slum of Nairobi, Kenya are at risk for fecal-orally transmitted infections. : Objective : To quantify the ...

File Type:

[PDF - 58.79 KB]