Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Oberste, M. Steven; Gotuzzo, Eduardo; Blair, Patrick; Nix, W. Allan; Ksiazek, Thomas G.; Comer, James A.; Rollin, Pierre; Goldsmith, Cynthia S.; Olson, James; Kochel, Tadeusz J.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Published Date:

Apr 2009

Source:

Emerg Infect Dis. 15(4):640-646.

[PDF-356.37 KB]

Details:

Personal Authors:

Oberste, M. Steven ; Gotuzzo, Eduardo ; Blair, Patrick ; Nix, W. Allan ; Ksiazek, Thomas G. ; ... More ▼

Keywords:

[+]

Description:

Etiologic studies of acute febrile disease were conducted in sites across South America, including Cusco and Iquitos, Peru. Patients' clinical signs and symptoms were recorded, and acute- and convalescent-phase serum samples were obtained for serologic examination and virus isolation in Vero E6 and C6/36 cells. Virus isolated in Vero E6 cells was identified as encephalomyocarditis virus (EMCV) by electron microscopy and by subsequent molecular diagnostic testing of samples from 2 febrile patients with nausea, headache, and dyspnea. The virus was recovered from acute-phase serum samples from both case-patients and identified with cardiovirus-specific reverse transcription-PCR and sequencing. Serum samples from case-patient 1 showed cardiovirus antibody by immunoglobulin M ELISA (acute phase <8, convalescent phase >1,024) and by neutralization assay (acute phase <10, convalescent phase >1,280). Serum samples from case-patient 2 did not contain antibodies detectable by either assay. Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases
CDC Public Access

Supporting Files:

	08-1428-F1.gif	image/gif
	08-1428-F1.jpg	image/jpeg
	08-1428-F2.gif	image/gif
	08-1428-F2.jpg	image/jpeg
	08-1428_finalR.nxml	text/plain
	license.txt	text/plain

No Related Documents.

You May Also Like:

Diversity of picornaviruses in rural Bolivia

Personal Author:

Nix, W. Allan; Khetsuriani, Nino; Peñaranda, Silvia; Maher, Kaija; Venczel, Linda; Cselkó, Zsuzsa; Freire, Maria Cecelia; Cisterna, Daniel; Lema, Cristina L.; Rosales, Patricia; Rodriguez, Jacqueline R.; Rodriguez, Wilma; Halkyer, Percy; Ronveaux, Olivier; Pallansch, Mark A.; Oberste, M. Steven;

Published:

Jun 26 2013

Source:

J Gen Virol. 94(0 9):2017-2028.

Description:

The family Picornaviridae is a large and diverse group of viruses that infect humans and animals. Picornaviruses are among the most common infections of humans and cause a wide spectrum of acute human disease. This study began as an investigation of ...

File Type:

[PDF - 2.48 MB]
Serious Invasive Saffold Virus Infections in Children, 2009

Personal Author:

Nielsen, Alex Christian Yde; Böttiger, Blenda; Banner, Jytte; Hoffmann, Thomas; Nielsen, Lars Peter;

Published:

Jan 2012

Source:

Emerg Infect Dis. 18(1):7-12.

Description:

The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated ...

File Type:

[PDF - 245.32 KB]
Enterovirus surveillance--United States, 1970-2005

Personal Author:

LaMonte-Fowlkes, Ashley; Oberste, M. Steven; Pallansch, Mark A.;

Corporate Author:

National Center for Infectious Diseases (U.S.). Respiratory and Enterovirus Branch. Khetsuriani, Nino. Centers for Disease Control and Prevention (U.S.).

Published:

September 16, 2006

Series:

MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries ; v. 55, no. SS-8

Description:

"PROBLEM: Enteroviruses are common human viruses associated with various clinical syndromes, from minor febrile illness to severe, potentially fatal conditions (e.g., aseptic meningitis, paralysis, myocarditis, and neonatal enteroviral sepsis). Multi...

File Type:

[PDF - 249.98 KB]
Circulation of 3 Lineages of a Novel Saffold Cardiovirus in Humans

Personal Author:

Drexler, Jan Felix; de Souza Luna, Luciano Kleber; Stöcker, Andreas; Almeida, Patrícia Silva; Ribeiro, Tereza Cristina Medrado; Petersen, Nadine; Herzog, Petra; Pedroso, Célia; Huppertz, Hans Iko; da Costa Ribeiro, Hugo; Baumgarte, Sigrid; Drosten, Christian;

Published:

Sep 2008

Source:

Emerg Infect Dis. 14(9):1398-1405

Description:

Cardioviruses cause serious disease, mainly in rodents, including diabetes, myocarditis, encephalomyelitis, and multiple sclerosis-like disseminated encephalomyelitis. Recently, a human virus isolate obtained 25 years ago, termed Saffold virus, was s...

File Type:

[PDF - 251.07 KB]
An apparently new virus (family Paramyxoviridae) infectious for pigs, humans, and fruit bats.

Personal Author:

Philbey, A. W.; Kirkland, P. D.; Ross, A. D.; Davis, R. J.; Gleeson, A. B.; Love, R. J.; Daniels, P. W.; Gould, A. R.; Hyatt, A. D.;

Published:

1998 Apr-Jun

Source:

Emerg Infect Dis. 4(2):269-271.

Description:

We isolated an apparently new virus in the family Paramyxoviridae from stillborn piglets with deformities at a piggery in New South Wales, Australia. In 1997, the pregnancy rate and litter size at the piggery decreased markedly, while the proportion ...

File Type:

[PDF - 99.99 KB]