Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Oberste, M. Steven; Gotuzzo, Eduardo; Blair, Patrick; Nix, W. Allan; Ksiazek, Thomas G.; Comer, James A.; Rollin, Pierre; Goldsmith, Cynthia S.; Olson, James; Kochel, Tadeusz J.

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Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Published Date:

Apr 2009

Source:

Emerg Infect Dis. 15(4):640-646.

[PDF-356.37 KB]

Details:

Personal Authors:

Oberste, M. Steven ; Gotuzzo, Eduardo ; Blair, Patrick ; Nix, W. Allan ; Ksiazek, Thomas G. ; ... More ▼

Keywords:

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Description:

Etiologic studies of acute febrile disease were conducted in sites across South America, including Cusco and Iquitos, Peru. Patients' clinical signs and symptoms were recorded, and acute- and convalescent-phase serum samples were obtained for serologic examination and virus isolation in Vero E6 and C6/36 cells. Virus isolated in Vero E6 cells was identified as encephalomyocarditis virus (EMCV) by electron microscopy and by subsequent molecular diagnostic testing of samples from 2 febrile patients with nausea, headache, and dyspnea. The virus was recovered from acute-phase serum samples from both case-patients and identified with cardiovirus-specific reverse transcription-PCR and sequencing. Serum samples from case-patient 1 showed cardiovirus antibody by immunoglobulin M ELISA (acute phase <8, convalescent phase >1,024) and by neutralization assay (acute phase <10, convalescent phase >1,280). Serum samples from case-patient 2 did not contain antibodies detectable by either assay. Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases
CDC Public Access

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