Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Oberste, M. Steven; Gotuzzo, Eduardo; Blair, Patrick; Nix, W. Allan; Ksiazek, Thomas G.; Comer, James A.; Rollin, Pierre; Goldsmith, Cynthia S.; Olson, James; Kochel, Tadeusz J.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Human Febrile Illness Caused by Encephalomyocarditis Virus Infection, Peru

Published Date:

Apr 2009

Source:

Emerg Infect Dis. 15(4):640-646.

[PDF-356.37 KB]

Details:

Personal Authors:

Oberste, M. Steven ; Gotuzzo, Eduardo ; Blair, Patrick ; Nix, W. Allan ; Ksiazek, Thomas G. ; ... More ▼

Keywords:

[+]

Description:

Etiologic studies of acute febrile disease were conducted in sites across South America, including Cusco and Iquitos, Peru. Patients' clinical signs and symptoms were recorded, and acute- and convalescent-phase serum samples were obtained for serologic examination and virus isolation in Vero E6 and C6/36 cells. Virus isolated in Vero E6 cells was identified as encephalomyocarditis virus (EMCV) by electron microscopy and by subsequent molecular diagnostic testing of samples from 2 febrile patients with nausea, headache, and dyspnea. The virus was recovered from acute-phase serum samples from both case-patients and identified with cardiovirus-specific reverse transcription-PCR and sequencing. Serum samples from case-patient 1 showed cardiovirus antibody by immunoglobulin M ELISA (acute phase <8, convalescent phase >1,024) and by neutralization assay (acute phase <10, convalescent phase >1,280). Serum samples from case-patient 2 did not contain antibodies detectable by either assay. Detection of virus in serum strongly supports a role for EMCV in human infection and febrile illness.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases
CDC Public Access

Supporting Files:

	08-1428-F1.gif	image/gif
	08-1428-F1.jpg	image/jpeg
	08-1428-F2.gif	image/gif
	08-1428-F2.jpg	image/jpeg
	08-1428_finalR.nxml	text/plain
	license.txt	text/plain

No Related Documents.

You May Also Like:

Diversity of picornaviruses in rural Bolivia

Personal Author:

Nix, W. Allan; Khetsuriani, Nino; Peñaranda, Silvia; Maher, Kaija; Venczel, Linda; Cselkó, Zsuzsa; Freire, Maria Cecelia; Cisterna, Daniel; Lema, Cristina L.; Rosales, Patricia; Rodriguez, Jacqueline R.; Rodriguez, Wilma; Halkyer, Percy; Ronveaux, Olivier; Pallansch, Mark A.; Oberste, M. Steven;

Published:

Jun 26 2013

Source:

J Gen Virol. 94(0 9):2017-2028.

Description:

The family Picornaviridae is a large and diverse group of viruses that infect humans and animals. Picornaviruses are among the most common infections of humans and cause a wide spectrum of acute human disease. This study began as an investigation of ...

File Type:

[PDF - 2.48 MB]
Serious Invasive Saffold Virus Infections in Children, 2009

Personal Author:

Nielsen, Alex Christian Yde; Böttiger, Blenda; Banner, Jytte; Hoffmann, Thomas; Nielsen, Lars Peter;

Published:

Jan 2012

Source:

Emerg Infect Dis. 18(1):7-12.

Description:

The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated ...

File Type:

[PDF - 245.32 KB]
Venezuelan Equine Encephalitis and 2 Human Deaths, Peru

Personal Author:

Vilcarromero, Stalin; Aguilar, Patricia V.; Halsey, Eric S.; Laguna-Torres, Alberto; Razuri, Hugo; Perez, Juan; Valderrama, Yadira; Gotuzzo, Eduardo; Suárez, Luis; Céspedes, Manuel; Kochel, Tadeusz J.;

Published:

Mar 2010

Source:

Emerg Infect Dis. 16(3):553-556.

Description:

Studies have suggested that enzootic strains of Venezuelan equine encephalitis (VEE) subtype ID in the Amazon region, Peru, may be less pathogenic to humans than are epizootic variants. Deaths of 2 persons with evidence of acute VEE virus infection i...

File Type:

[PDF - 161.26 KB]
Endemic Venezuelan Equine Encephalitis in Northern Peru

Personal Author:

Aguilar, Patricia V.; Greene, Ivorlyne P.; Coffey, Lark L.; Medina, Gladys; Moncayo, Abelardo C.; Anishchenko, Michael; Ludwig, George V.; Turell, Michael J.; O’Guinn, Monica L.; Lee, John; Tesh, Robert B.; Watts, Douglas M.; Russell, Kevin L.; Hice, Christine; Yanoviak, Stephen; Morrison, Amy C.; Klein, Terry A.; Dohm, David J.; Guzman, Hilda; Travassos da Rosa, Amelia P.A.; Guevara, Carolina; Kochel, Tadeusz; Olson, James; Cabezas, Cesar; Weaver, Scott C.;

Published:

May 2004

Source:

Emerg Infect Dis. 10(5):880-888.

Description:

Since Venezuelan equine encephalitis virus (VEEV) was isolated in Peru in 1942, >70 isolates have been obtained from mosquitoes, humans, and sylvatic mammals primarily in the Amazon region. To investigate genetic relationships among the Peru VEEV iso...

File Type:

[PDF - 480.28 KB]
Itaya virus, a Novel Orthobunyavirus Associated with Human Febrile Illness, Peru

Personal Author:

Hontz, Robert D.; Guevara, Carolina; Halsey, Eric S.; Silvas, Jesus; Santiago, Felix W.; Widen, Steven G.; Wood, Thomas G.; Casanova, Wilma; Vasilakis, Nikos; Watts, Douglas M.; Kochel, Tadeusz J.; Ebihara, Hideki; Aguilar, Patricia V.;

Published:

May 2015

Source:

Emerg Infect Dis. 21(5):781-788.

Description:

Our genetic analyses of uncharacterized bunyaviruses isolated in Peru identified a possible reassortant virus containing small and large gene segment sequences closely related to the Caraparu virus and a medium gene segment sequence potentially deriv...

File Type:

[PDF - 1.89 MB]