Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia

Details

• Journal Article:
  Emerging Infectious Diseases
• Personal Author:
  Klempa, Boris ; Tkachenko, Evgeniy A. ; Dzagurova, Tamara K. ; Yunicheva, Yulia V. ; Morozov, Vyacheslav G. ; Okulova, Natalia M. ; Slyusareva, Galina P. ; Smirnov, Aleksey ; Kruger, Detlev H.
• Description:
  Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.
• Subjects:
  Adolescent Adult Animals Antibodies, Viral Cercopithecus Aethiops Female Hantavirus Infections Hemorrhagic Fever With Renal Syndrome Humans Male Middle Aged Orthohantavirus Phylogeny Rodentia Serotyping Vero Cells Zoonoses

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• Keywords:
  Rodents
• Series:
  Emerging Infectious Diseases
• DOI:
  https://doi.org/10.3201/eid1404.071310
• ISSN:
  1080-6059 (digital) ; 1080-6040 (print)
• Publisher:
  Centers for Disease Control and Prevention (CDC) (U.S.)
• Pubmed ID:
  18394280
• Pubmed Central ID:
  PMC2570905 
• Document Type:
  Text ; Journal Article
• Genre:
  Journal Article
• Place as Subject:
  Russia
• Rights:
  Public Domain
• Topic:
  Diseases & Conditions
• Location:
  Europe ; Asia
• Volume:
  14
• Issue:
  4
• Citation:
  Emerg Infect Dis. 14(4):617-625.
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha-512:f41ce2915e26ec77c356769414e612e40af3c15d0fa7422c34f627caa7e01a1a3312dbfa2773428858cd0d8ebc44df7b6fc26e8938e7025f832b85e4a033920b
• Download URL:
  https://stacks.cdc.gov/view/cdc/17067/cdc_17067_DS1.pdf
• File Type:
  [PDF - 325.98 KB ]