Hemorrhagic Fever with Renal Syndrome Caused by 2 Lineages of Dobrava Hantavirus, Russia1

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Klempa, Boris ; Tkachenko, Evgeniy A. ; Dzagurova, Tamara K. ; Yunicheva, Yulia V. ; Morozov, Vyacheslav G. ; Okulova, Natalia M. ; Slyusareva, Galina P. ; Smirnov, Aleksey ; Kruger, Detlev H.
• Description:
  Dobrava-Belgrade virus (DOBV) is a European hantavirus that causes hemorrhagic fever with renal syndrome (HFRS); case-fatality rates in Balkan countries are as high as 12%. To determine causative agents, we examined 126 cases of DOBV-associated HFRS in central and southern European Russia. In central Russia (Lipetsk, Voronezh, Orel regions), outbreaks were caused by a DOBV variant (DOBV-Aa) carried by Apodemus agrarius. In southern Russia (Sochi district), where HFRS is endemic, HFRS cases were caused by a new DOBV variant (DOBV-Ap), found in A. ponticus, a novel hantavirus natural host. Both viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were isolated through Vero E6 cells, genetically characterized, and used for serotyping of the HFRS patients' serum. The clinical severity of HFRS caused by DOBV-Aa resembles that of HFRS caused by Puumala virus (mild to moderate); clinical severity of disease caused by DOBV-Ap infections is more often moderate to severe.
• Subjects:
  Adolescent Adult Animals Antibodies, Viral Cercopithecus Aethiops Female Hantavirus Hemorrhagic Fever With Renal Syndrome Humans Male Middle Aged Phylogeny Research Rodentia Serotyping Vero Cells

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• Source:
  Emerg Infect Dis. 14(4):617-625.
• Document Type:
  Journal Article
• Place as Subject:
  Russia
• Location:
  Europe
• Volume:
  14
• Issue:
  4
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9fd94f40fc0539ead13bcf2eb3f359447e1f480be223e97024336c2827fa3c6f
• Download URL:
  https://stacks.cdc.gov/view/cdc/17067/cdc_17067_DS1.pdf
• File Type:
  [PDF - 325.98 KB ]