RECOVERY OF VASCULAR FUNCTION AFTER EXPOSURE TO A SINGLE BOUT OF SEGMENTAL VIBRATION

Details

• Alternative Title:
  J Toxicol Environ Health A
• Personal Author:
  Krajnak, Kristine ; Waugh, Stacey ; Miller, G. Roger ; Johnson, Claud
• Description:
  Work rotation schedules may be used to reduce the negative effects of vibration on vascular function. This study determined how long it takes vascular function to recover after a single exposure to vibration in rats (125 Hz, acceleration 5 g). The responsiveness of rat-tail arteries to the vasoconstricting factor UK14304, an α2C-adrenoreceptor agonist, and the vasodilating factor acetylcholine (ACh) were measured ex vivo 1, 2, 7, or 9 d after exposure to a single bout of vibration. Vasoconstriction induced by UK14304 returned to control levels after 1 d of recovery. However, re-dilation induced by ACh did not return to baseline until after 9 d of recovery. Exposure to vibration exerted prolonged effects on peripheral vascular function, and altered vascular responses to a subsequent exposure. To optimize the positive results of work rotation schedules, it is suggested that studies assessing recovery of vascular function after exposure to a single bout of vibration be performed in humans.
• Subjects:
  Acetylcholine Animals Arteries Article Disease Models, Animal Endothelium, Vascular Male Quinoxalines Rats Rats, Sprague-Dawley Time Factors Vasoconstriction Vibration

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• Source:
  J Toxicol Environ Health A. 77(17):1061-1069.
• Pubmed ID:
  25072825
• Pubmed Central ID:
  PMC4505626
• Document Type:
  Journal Article
• Funding:
  KSK1/Intramural CDC HHS/United States
• Volume:
  77
• Issue:
  17
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b8208514a10a7740487ad049285d1a30254aebfae1a8eaae7920f1fa792c5d31
• Download URL:
  https://stacks.cdc.gov/view/cdc/32081/cdc_32081_DS1.pdf
• File Type:
  [PDF - 1.87 MB ]