Details:

Alternative Title:
AIDS
Publisher's site:
http://dx.doi.org/10.1097/QAD.0000000000000617
Personal Author:
Chang, Tiffany S. ; Wiener, Jeffrey ; Dollard, Sheila C. ; Amin, Minal M. ; Ellington, Sascha ; ... More +
Chang, Tiffany S. ; Wiener, Jeffrey ; Dollard, Sheila C. ; Amin, Minal M. ; Ellington, Sascha ; Chasela, Charles ; Kayira, Dumbani ; Tegha, Gerald ; Kamwendo, Deborah ; Jamieson, Denise J. ; van der Horst, Charlie ; Kourtis, Athena P. ; Less -
Description:
Background Cytomegalovirus (CMV) infection can be acquired in utero or postnatally through horizontal transmission and breastfeeding. The effect of postnatal CMV infection on postnatal HIV transmission is unknown. Methods The Breastfeeding, Antiretrovirals and Nutrition study, conducted in Malawi, randomized 2369 mothers and their infants to three antiretroviral prophylaxis arms –mother (triple regimen), infant (nevirapine), or neither – for 28 weeks of breastfeeding, followed by weaning. Stored plasma and peripheral blood mononuclear cell specimens were available for 492 infants at 24 weeks and were tested with CMV PCR. Available samples from infants who were CMV PCR-positive at 24 weeks were also tested at birth (N = 242), and from infants PCR-negative at 24 weeks were tested at 48 weeks (N = 96). Cox proportional-hazards models were used to determine if CMV infection was associated with infant morbidity, mortality, or postnatal HIV acquisition. Results At 24 weeks of age, CMV DNA was detected in 345/492 infants (70.1%); the estimated congenital CMV infection rate was 2.3%, and the estimated rate of CMV infection at 48 weeks was 78.5%. CMV infection at 24 weeks was associated with subsequent HIV acquisition through breastfeeding or infant death between 24 and 48 weeks of age (hazard ratio 4.27, P = 0.05). Conclusion Most breastfed infants of HIV-infected mothers in this resource-limited setting are infected with CMV by 24 weeks of age. Early CMV infection may be a risk factor for subsequent infant HIV infection through breastfeeding, pointing to the need for comprehensive approaches in order to achieve elimination of breastfeeding transmission of HIV.
Subject:
[+]
Article
Breast Feeding
Cytomegalovirus
Cytomegalovirus Infections
Disease Transmission, Infectious
DNA, Viral
Female
HIV Infections
Humans
Incidence
Infant
Infant, Newborn
Leukocytes, Mononuclear
Male
Plasma
Polymerase Chain Reaction
Pregnancy

Source:
AIDS. 2015; 29(7):831-836.
Pubmed ID:
25985405
Pubmed Central ID:
PMC4493887
Document Type:
Journal Article ;
Funding:
2-D43 TW01039-06/TW/FIC NIH HHS/United States ; D43 TW001039/TW/FIC NIH HHS/United States ; P30 AI050410/AI/NIAID NIH HHS/United States ; R24 TW00798/TW/FIC NIH HHS/United States ; R24 TW007988/TW/FIC NIH HHS/United States ; ... More +
2-D43 TW01039-06/TW/FIC NIH HHS/United States ; D43 TW001039/TW/FIC NIH HHS/United States ; P30 AI050410/AI/NIAID NIH HHS/United States ; R24 TW00798/TW/FIC NIH HHS/United States ; R24 TW007988/TW/FIC NIH HHS/United States ; U48-CCU409660-09/PHS HHS/United States ; U48-DP000059-01/DP/NCCDPHP CDC HHS/United States ; U48-DP001944-01/DP/NCCDPHP CDC HHS/United States ; Less -
Place as Subject:
Malawi ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:4f4e06ec2a907c6d3d42c79252ea83b3625880dae72b5e5af7e71dbec1d7b13f
File Type:

Supporting Files

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