Malaria Prevalence among Young Infants in Different Transmission Settings, Africa

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Ceesay, Serign J. ; Koivogui, Lamine ; Nahum, Alain ; Taal, Makie Abdoulie ; Okebe, Joseph ; Affara, Muna ; Kaman, Lama Eugène ; Bohissou, Francis ; Agbowai, Carine ; Tolno, Benoit Gniouma ; Amambua-Ngwa, Alfred ; Bangoura, NFaly ; Ahounou, Daniel ; Muhammad, Abdul Khalie ; Duparc, Stephan ; Hamed, Kamal ; Ubben, David ; Bojang, Kalifa ; Achan, Jane ; D’Alessandro, Umberto
• Description:
  The prevalence and consequences of malaria among infants are not well characterized and may be underestimated. A better understanding of the risk for malaria in early infancy is critical for drug development and informed decision making. In a cross-sectional survey in Guinea, The Gambia, and Benin, countries with different malaria transmission intensities, the overall prevalence of malaria among infants <6 months of age was 11.8% (Guinea, 21.7%; The Gambia, 3.7%; and Benin, 10.2%). Seroprevalence ranged from 5.7% in The Gambia to 41.6% in Guinea. Mean parasite densities in infants were significantly lower than those in children 1-9 years of age in The Gambia (p<0.0001) and Benin (p = 0.0021). Malaria in infants was significantly associated with fever or recent history of fever (p = 0.007) and anemia (p = 0.001). Targeted preventive interventions, adequate drug formulations, and treatment guidelines are needed to address the sizeable prevalence of malaria among young infants in malaria-endemic countries.
• Subjects:
  Adolescent Antibodies, Protozoan Child Child, Preschool Cross-Sectional Studies Endemic Diseases Humans Infant Infant, Newborn Malaria, Falciparum Prevalence Research Seroepidemiologic Studies

  More +
• Source:
  Emerg Infect Dis. 21(7):1114-1121
• Pubmed ID:
  26079062
• Pubmed Central ID:
  PMC4480393
• Document Type:
  Journal Article
• Funding:
  MC_EX_MR/K02440X/1/Medical Research Council/United Kingdom ; MC_UP_A900_1117/Medical Research Council/United Kingdom ; MC_UP_A900_1118/Medical Research Council/United Kingdom ; MC_UP_A900_1119/Medical Research Council/United Kingdom
• Place as Subject:
  Benin ; Gambia ; Guinea
• Location:
  Africa
• Volume:
  21
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:e702143d16f5393c30c5969e9634bc022bf8dbb1daa69668938145dd0c395ed7
• Download URL:
  https://stacks.cdc.gov/view/cdc/31835/cdc_31835_DS1.pdf
• File Type:
  [PDF - 904.13 KB ]