Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Bousema, Teun ; Youssef, Randa M. ; Cook, Jackie ; Cox, Jonathan ; Alegana, Victor A. ; ... More +
Bousema, Teun ; Youssef, Randa M. ; Cook, Jackie ; Cox, Jonathan ; Alegana, Victor A. ; Amran, Jamal ; Noor, Abdisalan M. ; Snow, Robert W. ; Drakeley, Chris ; Less -
Description:
Areas in which malaria is not highly endemic are suitable for malaria elimination, but assessing transmission is difficult because of lack of sensitivity of commonly used methods. We evaluated serologic markers for detecting variation in malaria exposure in Somalia. Plasmodium falciparum or P. vivax was not detected by microscopy in cross-sectional surveys of samples from persons during the dry (0/1,178) and wet (0/1,128) seasons. Antibody responses against P. falciparum or P. vivax were detected in 17.9% (179/1,001) and 19.3% (202/1,044) of persons tested. Reactivity against P. falciparum was significantly different between 3 villages (p<0.001); clusters of seroreactivity were present. Distance to the nearest seasonal river was negatively associated with P. falciparum (p = 0.028) and P. vivax seroreactivity (p = 0.016). Serologic markers are a promising tool for detecting spatial variation in malaria exposure and evaluating malaria control efforts in areas where transmission has decreased to levels below the detection limit of microscopy.
Subject:
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Adolescent
Animals
Anopheles
Antibodies, Protozoan
Child
Child, Preschool
Cross-Sectional Studies
Heterogeneity
Humans
Immunity
Malaria
Malaria, Falciparum
Malaria, Vivax
Parasites
Plasmodium Falciparum
Plasmodium Vivax
Prevalence
Research
Seasons
Serology
Transmission

Source:
Emerg Infect Dis. 16(3):392-399. ;
Document Type:
Journal Article ;
Place as Subject:
Somalia ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:9a0f8dbfb77db2f14cf0448bb80584453dfdf1ccb17121d943a8e163a0f6ff9c
File Type:

Supporting Files

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  	09-0732_finalR.nxml	txt
  	license.txt	txt

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