Seroprevalence for Hepatitis E and Other Viral Hepatitides among Diverse Populations, Malawi

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Taha, Taha E. ; Rusie, Laura K. ; Labrique, Alain ; Nyirenda, Mulinda ; Soko, Dean ; Kamanga, Melvin ; Kumwenda, Johnstone ; Farazadegan, Homayoon ; Nelson, Kenrad ; Kumwenda, Newton
• Description:
  Data on prevalence of hepatitis E virus (HEV) in Malawi is limited. We tested blood samples from HIV-uninfected and -infected populations of women and men enrolled in research studies in Malawi during 1989-2008 to determine the seroprevalence of HEV, hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV). Samples were tested for IgG against HEV, total antibodies against HAV and HCV, and presence of HBV surface antigens. Of 800 samples tested, 16.5% were positive for HEV IgG, 99.6% were positive for HAV antibodies, 7.5% were positive for HBV surface antigen, and 7.1% were positive for HCV antibodies. No clear trends over time were observed in the seroprevalence of HEV, and HIV status was not associated with hepatitis seroprevalence. These preliminary data suggest that the seroprevalence of HEV is high in Malawi; the clinical effects may be unrecognized or routinely misclassified.
• Subjects:
  Adolescent Adult Aged Female Hepatitis E Hepatitis E Virus Hiv Infections Humans Male Middle Aged Multivariate Analysis Prevalence Research Seroepidemiologic Studies Young Adult

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• Source:
  Emerg Infect Dis. 21(7):1174-1182
• Pubmed ID:
  26079666
• Pubmed Central ID:
  PMC4480384
• Document Type:
  Journal Article
• Place as Subject:
  Malawi
• Location:
  Africa
• Volume:
  21
• Issue:
  7
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:37cabb7c15d22c9dfc5e224323dcafd85525d2c6c0318a605ca5c33392c8cb95
• Download URL:
  https://stacks.cdc.gov/view/cdc/31826/cdc_31826_DS1.pdf
• File Type:
  [PDF - 656.53 KB ]