Kinetics of Hepatitis E Virus Infections in Asymptomatic Persons

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Plümers, Ricarda ; Dreier, Jens ; Knabbe, Cornelius ; Steinmann, Eike ; Todt, Daniel ; Vollmer, Tanja
• Description:
  To determine the kinetics of hepatitis E virus (HEV) in asymptomatic persons and to evaluate viral load doubling time and half-life, we retrospectively tested samples retained from 32 HEV RNA-positive asymptomatic blood donors in Germany. Close-meshed monitoring of viral load and seroconversion in intervals of ≈4 days provided more information about the kinetics of asymptomatic HEV infections. We determined that a typical median infection began with PCR-detectable viremia at 36 days and a maximum viral load of 2.0 × 10| IU/mL. Viremia doubled in 2.4 days and had a half-life of 1.6 days. HEV IgM started to rise on about day 33 and peaked on day 36; IgG started to rise on about day 32 and peaked on day 53. Although HEV IgG titers remained stable, IgM titers became undetectable in 40% of donors. Knowledge of the dynamics of HEV viremia is useful for assessing the risk for transfusion-transmitted hepatitis E.
• Subjects:
  Adult Asymptomatic Infections Blood Donors Female Germany Hepatitis Antibodies Hepatitis E Hepatitis E Virus Humans Immunoglobulin G Immunoglobulin M Kinetics Male Middle Aged Retrospective Studies RNA, Viral Viral Load Viremia Young Adult

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• Keywords:
  Asymptomatic Blood Safety Doubling Time Hepatitis Immune Response Transfusion Viruses
• Source:
  Emerg Infect Dis. 2024; 30(5):934-940
• Pubmed ID:
  38666600
• Pubmed Central ID:
  PMC11060471
• Document Type:
  Journal Article
• Volume:
  30
• Issue:
  5
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:b5df62ed15b269892ad13069a092e641ee8e0609fb8d1847b78bad8421cca0e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/154884/cdc_154884_DS1.pdf
• File Type:
  [PDF - 830.15 KB ]