Factors affecting maternal participation in the genetic component of the National Birth Defects Prevention Study—United States, 1997–2007

Details

• Alternative Title:
  Genet Med
• Personal Author:
  Glidewell, Jill ; Reefhuis, Jennita ; Rasmussen, Sonja A. ; Woomert, Alison ; Hobbs, Charlotte ; Romitti, Paul A. ; Crider, Krista S.
• Description:
  Purpose
  
  As epidemiological studies expand to examine gene–environment interaction effects, it is important to identify factors associated with participation in genetic studies. The National Birth Defects Prevention Study is a multisite case–control study designed to investigate environmental and genetic risk factors for major birth defects. The National Birth Defects Prevention Study includes maternal telephone interviews and mailed buccal cell self-collection kits. Because subjects can participate in the interview, independent of buccal cell collection, detailed analysis of factors associated with participation in buccal cell collection was possible.
  
  Methods
  
  Multivariable logistic regression models were used to identify the factors associated with participation in the genetic component of the study.
  
  Results
  
  Buccal cell participation rates varied by race/ethnicity (non-Hispanic whites, 66.9%; Hispanics, 60.4%; and non-Hispanic blacks, 47.3%) and study site (50.2–74.2%). Additional monetary incentive following return of buccal cell kit and shorter interval between infant’s estimated date of delivery and interview were associated with increased participation across all racial/ethnic groups. Higher education and delivering an infant with a birth defect were associated with increased participation among non-Hispanic whites and Hispanics.
  
  Conclusion
  
  Factors associated with participation varied by race/ethnicity. Improved understanding of factors associated with participation may facilitate strategies to increase participation, thereby improving generalizability of study findings.
  
  
• Subjects:
  Attitude To Health Case-Control Studies Congenital Abnormalities Female Humans Interviews As Topic Logistic Models Mouth Mucosa Patient Participation Risk Factors
• Source:
  Genet Med. 16(4):329-337.
• Pubmed ID:
  24071796
• Pubmed Central ID:
  PMC4471475
• Document Type:
  Journal Article
• Funding:
  IYP0/Intramural CDC HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States
• Volume:
  16
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e1e29a5c9aa5f59fc931a8ea7c419d0158cce8b2e2fb290028db5db915049b51
• Download URL:
  https://stacks.cdc.gov/view/cdc/31675/cdc_31675_DS1.pdf
• File Type:
  [PDF - 384.80 KB ]