Details:

Alternative Title:
Genet Med
Publisher's site:
http://dx.doi.org/10.1038/gim.2013.143
Personal Author:
Glidewell, Jill ; Reefhuis, Jennita ; Rasmussen, Sonja A. ; Woomert, Alison ; Hobbs, Charlotte ; ... More +
Glidewell, Jill ; Reefhuis, Jennita ; Rasmussen, Sonja A. ; Woomert, Alison ; Hobbs, Charlotte ; Romitti, Paul A. ; Crider, Krista S. ; Less -
Description:
Purpose As epidemiological studies expand to examine gene–environment interaction effects, it is important to identify factors associated with participation in genetic studies. The National Birth Defects Prevention Study is a multisite case–control study designed to investigate environmental and genetic risk factors for major birth defects. The National Birth Defects Prevention Study includes maternal telephone interviews and mailed buccal cell self-collection kits. Because subjects can participate in the interview, independent of buccal cell collection, detailed analysis of factors associated with participation in buccal cell collection was possible. Methods Multivariable logistic regression models were used to identify the factors associated with participation in the genetic component of the study. Results Buccal cell participation rates varied by race/ethnicity (non-Hispanic whites, 66.9%; Hispanics, 60.4%; and non-Hispanic blacks, 47.3%) and study site (50.2–74.2%). Additional monetary incentive following return of buccal cell kit and shorter interval between infant’s estimated date of delivery and interview were associated with increased participation across all racial/ethnic groups. Higher education and delivering an infant with a birth defect were associated with increased participation among non-Hispanic whites and Hispanics. Conclusion Factors associated with participation varied by race/ethnicity. Improved understanding of factors associated with participation may facilitate strategies to increase participation, thereby improving generalizability of study findings.
Subject:
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Article
Attitude To Health
Birth Defects
Case-Control Studies
Congenital Abnormalities
Data Collection
Epidemiologic Methods
Ethnic Groups
Female
Humans
Interviews As Topic
Logistic Models
Mouth Mucosa
Patient Participation
Risk Factors
Risk Factors

Source:
Genet Med. 16(4):329-337.
Pubmed ID:
24071796
Pubmed Central ID:
PMC4471475
Document Type:
Journal Article ;
Funding:
IYP0/Intramural CDC HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States ;
IYP0/Intramural CDC HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e1e29a5c9aa5f59fc931a8ea7c419d0158cce8b2e2fb290028db5db915049b51
File Type:

Supporting Files

• 	NIHMS698802-supplement-Table1.doc	doc
  	NIHMS698802-supplement-Table2.doc	doc
  	NIHMS698802-supplement-Table3.doc	doc
  	NIHMS698802-supplement-Table4.doc	doc
  	NIHMS698802-supplement-Table5.doc	doc
  	nihms698802.nxml	txt
  	nihms698802f1.gif	gif
  	nihms698802f1.jpg	jpeg

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