Factors affecting maternal participation in the genetic component of the National Birth Defects Prevention Study—United States, 1997–2007

Details

• Alternative Title:
  Genet Med
• Personal Author:
  Glidewell, Jill ; Reefhuis, Jennita ; Rasmussen, Sonja A. ; Woomert, Alison ; Hobbs, Charlotte ; Romitti, Paul A. ; Crider, Krista S.
• Description:
  Purpose ; As epidemiological studies expand to examine gene–environment interaction effects, it is important to identify factors associated with participation in genetic studies. The National Birth Defects Prevention Study is a multisite case–control study designed to investigate environmental and genetic risk factors for major birth defects. The National Birth Defects Prevention Study includes maternal telephone interviews and mailed buccal cell self-collection kits. Because subjects can participate in the interview, independent of buccal cell collection, detailed analysis of factors associated with participation in buccal cell collection was possible. ; Methods ; Multivariable logistic regression models were used to identify the factors associated with participation in the genetic component of the study. ; Results ; Buccal cell participation rates varied by race/ethnicity (non-Hispanic whites, 66.9%; Hispanics, 60.4%; and non-Hispanic blacks, 47.3%) and study site (50.2–74.2%). Additional monetary incentive following return of buccal cell kit and shorter interval between infant’s estimated date of delivery and interview were associated with increased participation across all racial/ethnic groups. Higher education and delivering an infant with a birth defect were associated with increased participation among non-Hispanic whites and Hispanics. ; Conclusion ; Factors associated with participation varied by race/ethnicity. Improved understanding of factors associated with participation may facilitate strategies to increase participation, thereby improving generalizability of study findings.
• Subjects:
  • Attitude to Health
  • Case-Control Studies
  • Congenital Abnormalities
  • Female
  • Humans
  • Interviews as Topic
  • Logistic Models
  • Mouth Mucosa
  • Patient Participation
  • Risk Factors
• Source:
  Genet Med. 16(4):329-337.
• Pubmed ID:
  24071796
• Pubmed Central ID:
  PMC4471475
• Document Type:
  Journal Article
• Funding:
  IYP0/Intramural CDC HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States
• Volume:
  16
• Issue:
  4
• Download URL:
  https://stacks.cdc.gov/view/cdc/31675/cdc_31675_DS1.pdf
• File Type:
  [PDF - 384.80 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:e1e29a5c9aa5f59fc931a8ea7c419d0158cce8b2e2fb290028db5db915049b51