Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Shah, N. Sarita ; Wright, Abigail ; Bai, Gill-Han ; Barrera, Lucia ; Boulahbal, Fadila ; ... More +
Shah, N. Sarita ; Wright, Abigail ; Bai, Gill-Han ; Barrera, Lucia ; Boulahbal, Fadila ; Martín-Casabona, Nuria ; Drobniewski, Francis ; Gilpin, Chris ; Havelková, Marta ; Lepe, Rosario ; Lumb, Richard ; Metchock, Beverly ; Portaels, Françoise ; Rodrigues, Maria Filomena ; Rüsch-Gerdes, Sabine ; Van Deun, Armand ; Vincent, Veronique ; Laserson, Kayla ; Wells, Charles ; Cegielski, J. Peter Less -
Description:
Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to > or = 3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.
Subjects:
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Antitubercular Agents Communicable Disease Control Global Health Humans Laboratories Research Sentinel Surveillance Tuberculosis Tuberculosis, Multidrug-Resistant
Source:
Emerg Infect Dis. 13(3):380-387.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:a468d206761ab2b9150a9637f386f236f4b1b4aff1a045dead35bc64ab6a5c95
Download URL:
https://stacks.cdc.gov/view/cdc/3167/cdc_3167_DS1.pdf
File Type:

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