Worldwide Emergence of Extensively Drug-resistant Tuberculosis

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Shah, N. Sarita ; Wright, Abigail ; Bai, Gill-Han ; Barrera, Lucia ; Boulahbal, Fadila ; Martín-Casabona, Nuria ; Drobniewski, Francis ; Gilpin, Chris ; Havelková, Marta ; Lepe, Rosario ; Lumb, Richard ; Metchock, Beverly ; Portaels, Françoise ; Rodrigues, Maria Filomena ; Rüsch-Gerdes, Sabine ; Van Deun, Armand ; Vincent, Veronique ; Laserson, Kayla ; Wells, Charles ; Cegielski, J. Peter
• Description:
  Mycobacterium tuberculosis strains that are resistant to an increasing number of second-line drugs used to treat multidrug-resistant tuberculosis (MDR TB) are becoming a threat to public health worldwide. We surveyed the Network of Supranational Reference Laboratories for M. tuberculosis isolates that were resistant to second-line anti-TB drugs during 2000-2004. We defined extensively drug-resistant TB (XDR TB) as MDR TB with further resistance to > or = 3 of the 6 classes of second-line drugs. Of 23 eligible laboratories, 14 (61%) contributed data on 17,690 isolates, which reflected drug susceptibility results from 48 countries. Of 3,520 (19.9%) MDR TB isolates, 347 (9.9%) met criteria for XDR TB. Further investigation of population-based trends and expanded efforts to prevent drug resistance and effectively treat patients with MDR TB are crucial for protection of public health and control of TB.
• Subjects:
  Antitubercular Agents Communicable Disease Control Global Health Humans Laboratories Research Sentinel Surveillance Tuberculosis Tuberculosis, Multidrug-Resistant
• Source:
  Emerg Infect Dis. 13(3):380-387.
• Document Type:
  Journal Article
• Volume:
  13
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:a468d206761ab2b9150a9637f386f236f4b1b4aff1a045dead35bc64ab6a5c95
• Download URL:
  https://stacks.cdc.gov/view/cdc/3167/cdc_3167_DS1.pdf
• File Type:
  [PDF - 227.07 KB ]