Additional Drug Resistance of Multidrug-Resistant Tuberculosis in Patients in 9 Countries

Kurbatova, Ekaterina V.; Dalton, Tracy; Ershova, Julia; Tupasi, Thelma; Caoili, Janice Campos; Van Der Walt, Martie; Kvasnovsky, Charlotte; Yagui, Martin; Bayona, Jaime; Contreras, Carmen; Leimane, Vaira; Via, Laura E.; Kim, HeeJin; Akksilp, Somsak; Kazennyy, Boris Y.; Volchenkov, Grigory V.; Jou, Ruwen; Kliiman, Kai; Demikhova, Olga V.; Cegielski, J. Peter

doi:10.3201/eid2106.141329

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Additional Drug Resistance of Multidrug-Resistant Tuberculosis in Patients in 9 Countries

Jun 2015
By Kurbatova, Ekaterina V. ; Dalton, Tracy ; Ershova, Julia ; ...
http://dx.doi.org/10.3201/eid2106.141329
Source: Emerg Infect Dis. 21(6):977-983.

[PDF-705.41 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Kurbatova, Ekaterina V. ; Dalton, Tracy ; Ershova, Julia ; Tupasi, Thelma ; Caoili, Janice Campos ; ... More +

Kurbatova, Ekaterina V. ; Dalton, Tracy ; Ershova, Julia ; Tupasi, Thelma ; Caoili, Janice Campos ; Van Der Walt, Martie ; Kvasnovsky, Charlotte ; Yagui, Martin ; Bayona, Jaime ; Contreras, Carmen ; Leimane, Vaira ; Via, Laura E. ; Kim, HeeJin ; Akksilp, Somsak ; Kazennyy, Boris Y. ; Volchenkov, Grigory V. ; Jou, Ruwen ; Kliiman, Kai ; Demikhova, Olga V. ; Cegielski, J. Peter Less -
Description:

Data from a large multicenter observational study of patients with multidrug-resistant tuberculosis (MDR TB) were analyzed to simulate the possible use of 2 new approaches to treatment of MDR TB: a short (9-month) regimen and a bedaquiline-containing regimen. Of 1,254 patients, 952 (75.9%) had no resistance to fluoroquinolones and second-line injectable drugs and thus would qualify as candidates for the 9-month regimen; 302 (24.1%) patients with resistance to a fluoroquinolone or second-line injectable drug would qualify as candidates for a bedaquiline-containing regimen in accordance with published guidelines. Among candidates for the 9-month regimen, standardized drug-susceptibility tests demonstrated susceptibility to a median of 5 (interquartile range 5-6) drugs. Among candidates for bedaquiline, drug-susceptibility tests demonstrated susceptibility to a median of 3 (interquartile range 2-4) drugs; 26% retained susceptibility to <2 drugs. These data may assist national TB programs in planning to implement new drugs and drug regimens.
Subjects:

[+]

Antitubercular Agents Drug Resistance, Multiple, Bacterial Extensively Drug-Resistant Tuberculosis Humans Microbial Sensitivity Tests Mycobacterium Tuberculosis/Drug Effects
Source:

Emerg Infect Dis. 21(6):977-983.
Document Type:

Journal Article
Volume:

21
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:d9efffcc1901116c78c1b50b08946c03926d173dbdc13e11aa2d43f3d51957f5
Download URL:

https://stacks.cdc.gov/view/cdc/31530/cdc_31530_DS1.pdf
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	14-1329.nxml	txt
	license.txt	txt

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