Sequence Type 4821 Clonal Complex Serogroup B Neisseria meningitidis in China, 1978–2013

Zhu, Bingqing; Xu, Zheng; Du, Pengcheng; Xu, Li; Sun, Xiaofang; Gao, Yuan; Shao, Zhujun

doi:10.3201/eid2106.140687

i

Sequence Type 4821 Clonal Complex Serogroup B Neisseria meningitidis in China, 1978–2013

Supporting Files Public Domain

Jun 2015
By Zhu, Bingqing ; Xu, Zheng ; Du, Pengcheng ; ...

File Language:

English

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Alternative Title:

Emerg Infect Dis
Personal Author:

Zhu, Bingqing ; Xu, Zheng ; Du, Pengcheng ; Xu, Li ; Sun, Xiaofang ; Gao, Yuan ; Shao, Zhujun
Description:

Serogroup B Neisseria meningitidis strains belonging to sequence type 4821 clonal complex (CC4821), a hyperinvasive lineage first identified for serogroup C in 2003, have been increasingly isolated in China. We characterized the outer membrane protein genes of 48 serogroup B and 214 serogroup C strains belonging to CC4821 and analyzed the genomic sequences of 22 strains. Four serogroup B strains had porin A (i.e., PorA), PorB, and ferric enterobactin transport (i.e., FetA) genotypes identical to those for serogroup C. Phylogenetic analysis of the genomic sequences showed that the 22 CC4821 strains from patients and healthy carriers were unevenly clustered into 2 closely related groups; each group contained serogroup B and C strains. Serogroup B strains appeared variable at the capsule locus, and several recombination events had occurred at uncertain breakpoints. These findings suggest that CC4821 serogroup C N. meningitidis is the probable origin of highly pathogenic CC4821 serogroup B strains.
Subjects:

Genome, Bacterial Genotype Geography History, 20th Century History, 21st Century Humans Meningitis, Meningococcal/epidemiology Meningitis, Meningococcal/history Meningitis, Meningococcal/microbiology Molecular Typing Neisseria Meningitidis, Serogroup B Phylogeny Population Surveillance Porins Quantitative Trait Loci Research Sequence Analysis, DNA Serogroup
Source:

Emerg Infect Dis. 21(6):925-932.
Document Type:

Journal Article
Place as Subject:

China
Location:

Asia
Volume:

21
Issue:

6
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:c8a179885776db7fb0b8aa844288828916dfe082a5e9a83fed4500531ef75840
Download URL:

https://stacks.cdc.gov/view/cdc/31452/cdc_31452_DS1.pdf
File Type:

[PDF - 3.22 MB ]

File Language:

English

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