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MyD88 signaling in T cells directs IgA-mediated control of the microbiota to promote health
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    Villablanca, Eduardo J.; Wang, Sen; De Calisto, Jaime; Gomes, Daniel C. O.; Kane, Maureen A.; Napoli, Joseph L.; Blaner, William S.; Kagechika, Hiroyuki; Blomhoff, Rune; Rosemblatt, Mario; Bono, Maria Rosa; von Andrian, Ulrich H.; Mora, J. Rodrigo;
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    Gastroenterology. 2011; 141(1):176-185.
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    BACKGROUND & AIMSGut-associated dendritic cells (DC) metabolize vitamin A into all-trans retinoic acid (RA), which is required to induce lymphocytes to localize to the gastrointestinal (GI) tract and promotes the differentiation of Foxp3+ regulatory ...
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    Nov 22 2011
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    Mol Aspects Med. 2011; 33(1):63-76.
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    The vitamin A (VA) metabolite all-trans retinoic acid (RA) plays a key role in mucosal immune responses. RA is produced by gut-associated dendritic cells (DC) and is required for generating gut-tropic lymphocytes and IgA-antibody-secreting cells (IgA...
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    Gut Microbes. 2014; 5(5):663-668.
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    From birth to adulthood, the gut microbiota matures from a simple community dominated by a few major bacterial groups into a highly diverse ecosystem that provides both benefits and challenges to the host. Currently there is great interest in identif...
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