Norovirus Infection and Disease in an Ecuadorian Birth Cohort: Association of Certain Norovirus Genotypes With Host FUT2 Secretor Status

Details

• Journal Article:
  J Infect Dis
• Personal Author:
  Lopman, Ben A. ; Trivedi, Tarak ; Vicuña, Yosselin ; Costantini, Veronica ; Collins, Nikail ; Gregoricus, Nicole ; Parashar, Umesh ; Sandoval, Carlos ; Broncano, Nely ; Vaca, Maritza ; Chico, Martha E. ; Vinjé, Jan ; Cooper, Philip J.
• Description:
  Although norovirus is the most common cause of gastroenteritis, there are few data on the community incidence of infection/disease or the patterns of acquired immunity or innate resistance to norovirus.|We followed a community-based birth cohort of 194 children in Ecuador with the aim to estimate (1) the incidence of norovirus gastroenteritis from birth to age 3 years, (2) the protective effect of norovirus infection against subsequent infection/disease, and (3) the association of infection and disease with FUT2 secretor status.|Over the 3-year period, we detected a mean of 2.26 diarrheal episodes per child (range, 0-12 episodes). Norovirus was detected in 260 samples (18%) but was not found more frequently in diarrheal samples (79 of 438 [18%]), compared with diarrhea-free samples (181 of 1016 [18%]; P = .919). A total of 66% of children had at least 1 norovirus infection during the first 3 years of life, and 40% of children had 2 infections. Previous norovirus infections were not associated with the risk of subsequent infection. All genogroup II, genotype 4 (GII.4) infections were among secretor-positive children (P < .001), but higher rates of non-GII.4 infections were found in secretor-negative children (relative risk, 0.56; P = .029).|GII.4 infections were uniquely detected in secretor-positive children, while non-GII.4 infections were more often found in secretor-negative children.
• Subjects:
  Caliciviridae Infections Child, Preschool Cohort Studies Diarrhea Feces Fucosyltransferases Gastroenteritis Genetic Predisposition To Disease Genotype Humans Incidence Infant Infant, Newborn Male Norovirus Saliva

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• DOI:
  http://dx.doi.org/10.1093/infdis/jiu672
• Pubmed ID:
  25505295
• Document Type:
  Text ; Journal Article
• Funding:
  100714/Wellcome Trust/United Kingdom
• Genre:
  Journal Article
• Place as Subject:
  Ecuador
• Volume:
  211
• Issue:
  11
• Citation:
  J Infect Dis. 2014; 211(11):1813-1821.
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:f2aa5ca684c8c720d39bc0428b890bd7ed6d03b005514a22464ff8c9c6a3de52c9765cd410708f298508a8a918b1c63463dca44b3b1cc24eae05f3ab484591f1
• Download URL:
  https://stacks.cdc.gov/view/cdc/31120/cdc_31120_DS1.pdf
• File Type:
  [PDF - 303.13 KB ]