Molecular epidemiology of noroviruses in children under 5 years of age with acute gastroenteritis in Yaoundé, Cameroon

Mugyia, Akongnwi E.; Ndze, Valentine N.; Akoachere, Jane-Francis T. K.; Browne, Hannah; Boula, Angeline; Ndombo, Paul Koki; Cannon, Jennifer L.; Vinjé, Jan; Ndip, Lucy M.

doi:10.1002/jmv.25380

i

Molecular epidemiology of noroviruses in children under 5 years of age with acute gastroenteritis in Yaoundé, Cameroon

Supporting Files

5 2019
By Mugyia, Akongnwi E. ; Ndze, Valentine N. ; Akoachere, Jane-Francis T. K. ; ...

File Language:

English

Details

Alternative Title:

J Med Virol
Personal Author:

Mugyia, Akongnwi E. ; Ndze, Valentine N. ; Akoachere, Jane-Francis T. K. ; Browne, Hannah ; Boula, Angeline ; Ndombo, Paul Koki ; Cannon, Jennifer L. ; Vinjé, Jan ; Ndip, Lucy M.
Description:

Norovirus is a common cause of acute gastroenteritis (AGE) among children in developing countries. Limited data on the prevalence and genetic variability of norovirus are available in Cameroon, where early childhood mortality due to AGE is common. We tested 902 fecal specimens from children younger than 5 years of age hospitalized with AGE between January 2010 and December 2013. Overall, 76 (8.4%) samples tested positive for norovirus, of which 83% (63/76) were among children below 12 months old. Most of the noroviruses detected were in children infected between July and December of each year. All norovirus-positive specimens were genotyped, with 80% (61/76) being GII.4 (three variants detected). Genotypes GI.2, GI.6, GII.1, GII.2, GII.3, GII.6, GII.16, GII.17, and GII.21 were also detected. Interestingly, GII.4 Sydney and GII.17 Kawasaki viruses were found as early as 2010, years before their emergence globally. This study suggests norovirus is a significant cause of moderate to severe gastroenteritis among young children in Cameroon. The results are important to highlight appropriate prevention and control strategies for reducing the burden of norovirus disease.
Subjects:

Caliciviridae Infections Cameroon Child, Preschool Feces Female Gastroenteritis Genotype Humans Infant Infant, Newborn Male Molecular Epidemiology Norovirus Prevalence Seasons
Keywords:

Acute Gastroenteritis (AGE) Genotypes Norovirus
Source:

J Med Virol. 91(5):738-743
Pubmed ID:

30570784
Pubmed Central ID:

PMC8978256
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/
Volume:

91
Issue:

5
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:895da2269770743b25c4315a30b0f995df029b8af8734d531a675ab8dd6a2870
Download URL:

https://stacks.cdc.gov/view/cdc/116015/cdc_116015_DS1.pdf
File Type:

[PDF - 729.53 KB ]

File Language:

English

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