Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin

Ndam, Nicaise Tuikue; Denoeud-Ndam, Lise; Doritchamou, Justin; Viwami, Firmine; Salanti, Ali; Nielsen, Morten A.; Fievet, Nadine; Massougbodji, Achille; Luty, Adrian J.F.; Deloron, Philippe

doi:10.3201/eid2105.141626

i

Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin

Supporting Files Public Domain

May 2015
By Ndam, Nicaise Tuikue ; Denoeud-Ndam, Lise ; Doritchamou, Justin ; ...

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Ndam, Nicaise Tuikue ; Denoeud-Ndam, Lise ; Doritchamou, Justin ; Viwami, Firmine ; Salanti, Ali ; Nielsen, Morten A. ; Fievet, Nadine ; Massougbodji, Achille ; Luty, Adrian J.F. ; Deloron, Philippe
Description:

Placental malaria is caused by Plasmodium falciparum-infected erythrocytes that bind to placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var gene, which interacts with chondroitin sulfate A (CSA). Consequences include maternal anemia and fetal growth retardation. Antibody-mediated immunity to placental malaria is acquired during successive pregnancies, but the target of VAR2CSA-specific protective antibodies is unclear. We assessed VAR2CSA-specific antibodies in pregnant women and analyzed their relationships with protection against placental infection, preterm birth, and low birthweight. Antibody responses to the N-terminal region of VAR2CSA during early pregnancy were associated with reduced risks for infections and low birthweight. Among women infected during pregnancy, an increase in CSA binding inhibition was associated with reduced risks for placental infection, preterm birth, and low birthweight. These data suggest that antibodies against VAR2CSA N-terminal region mediate immunity to placental malaria and associated outcomes. Our results validate current vaccine development efforts with VAR2CSA N-terminal constructs.
Subjects:

Antibodies Benin Erythrocytes Malaria Outcomes Parasites Placental Malaria Plasmodium Falciparum Pregnancy Protective Antibodies Against Placental Malaria And Poor Outcomes During Pregnancy, Benin Research VAR2CSA
Source:

Emerg Infect Dis. 21(5):813-823.
Document Type:

Journal Article
Place as Subject:

Benin
Location:

Africa
Volume:

21
Issue:

5
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:673e5e37c61a9465bc1558a3321d0b498832b30a705277dbe9a8c377251c3675
Download URL:

https://stacks.cdc.gov/view/cdc/30899/cdc_30899_DS1.pdf
File Type:

[PDF - 1.07 MB ]

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