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Nanoparticles, Lung Injury, and the Role of Oxidant Stress
Filetype[PDF - 1.66 MB]


Details:
  • Funding:
    OH07550/OH/NIOSH CDC HHS/United States
    P01 ES000628/ES/NIEHS NIH HHS/United States
    P01 ES00628/ES/NIEHS NIH HHS/United States
    P51 RR000169/RR/NCRR NIH HHS/United States
    RC1 ES018232/ES/NIEHS NIH HHS/United States
    RC1 ES018232/ES/NIEHS NIH HHS/United States
    RR00169/RR/NCRR NIH HHS/United States
    U01 ES020127/ES/NIEHS NIH HHS/United States
    U01 ES02027/ES/NIEHS NIH HHS/United States
    U54 OH007550/OH/NIOSH CDC HHS/United States
  • Document Type:
  • Collection(s):
  • Description:
    The emergence of engineered nanoscale materials has provided significant advancements in electronic, biomedical, and material science applications. Both engineered nanoparticles and nanoparticles derived from combustion or incidental processes exhibit a range of physical and chemical properties that induce inflammation and oxidative stress in biological systems. Oxidative stress reflects the imbalance between the generation of reactive oxygen species and the biochemical mechanisms to detoxify and repair the damage resulting from reactive intermediates. This review examines current research on incidental and engineered nanoparticles in terms of their health effects on lungs and the mechanisms by which oxidative stress via physicochemical characteristics influences toxicity or biocompatibility. Although oxidative stress has generally been thought of as an adverse biological outcome, this review also briefly discusses some of the potential emerging technologies to use nanoparticle-induced oxidative stress to treat disease in a site-specific fashion.