Nanoparticles, Lung Injury, and the Role of Oxidant Stress

Details

• Alternative Title:
  Annu Rev Physiol
• Personal Author:
  Madl, Amy K. ; Plummer, Laurel E. ; Carosino, Christopher ; Pinkerton, Kent E.
• Description:
  The emergence of engineered nanoscale materials has provided significant advancements in electronic, biomedical, and material science applications. Both engineered nanoparticles and nanoparticles derived from combustion or incidental processes exhibit a range of physical and chemical properties that induce inflammation and oxidative stress in biological systems. Oxidative stress reflects the imbalance between the generation of reactive oxygen species and the biochemical mechanisms to detoxify and repair the damage resulting from reactive intermediates. This review examines current research on incidental and engineered nanoparticles in terms of their health effects on lungs and the mechanisms by which oxidative stress via physicochemical characteristics influences toxicity or biocompatibility. Although oxidative stress has generally been thought of as an adverse biological outcome, this review also briefly discusses some of the potential emerging technologies to use nanoparticle-induced oxidative stress to treat disease in a site-specific fashion.
• Subjects:
  Acute Lung Injury Ambient Particulate Matter Animals Article Carbon Nanotubes DNA Damage Humans Lung Nanoparticles Nanostructures Oxidative Stress

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• Source:
  Annu Rev Physiol. 76:447-465.
• Document Type:
  Journal Article
• Funding:
  OH07550/OH/NIOSH CDC HHS/United States ; P01 ES000628/ES/NIEHS NIH HHS/United States ; P01 ES00628/ES/NIEHS NIH HHS/United States ; P51 RR000169/RR/NCRR NIH HHS/United States ; RC1 ES018232/ES/NIEHS NIH HHS/United States ; RC1 ES018232/ES/NIEHS NIH HHS/United States ; RR00169/RR/NCRR NIH HHS/United States ; U01 ES020127/ES/NIEHS NIH HHS/United States ; U01 ES02027/ES/NIEHS NIH HHS/United States ; U54 OH007550/OH/NIOSH CDC HHS/United States
• Volume:
  76
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:3ae63a5b288f0f6085e2c335eff955955a4eb63d2ecad5add118e4aff35c6c16
• Download URL:
  https://stacks.cdc.gov/view/cdc/30641/cdc_30641_DS1.pdf
• File Type:
  [PDF - 1.66 MB ]