Nanoparticles, lung injury, and the role of oxidant stress

Details

• Personal Author:
  Carosino C ; Madl AK ; Pinkerton KE ; Plummer LE
• Description:
  The emergence of engineered nanoscale materials has provided significant advancements in electronic, biomedical, and material science applications. Both engineered nanoparticles and nanoparticles derived from combustion or incidental processes exhibit a range of physical and chemical properties that induce inflammation and oxidative stress in biological systems. Oxidative stress reflects the imbalance between the generation of reactive oxygen species and the biochemical mechanisms to detoxify and repair the damage resulting from reactive intermediates. This review examines current research on incidental and engineered nanoparticles in terms of their health effects on lungs and the mechanisms by which oxidative stress via physicochemical characteristics influences toxicity or biocompatibility. Although oxidative stress has generally been thought of as an adverse biological outcome, this review also briefly discusses some of the potential emerging technologies to use nanoparticle-induced oxidative stress to treat disease in a site-specific fashion. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biochemistry DNA Immune System Lung Occupational Health Particulate Matter Respiratory System Safety
• Keywords:
  Airborne-particles Ambient Particulate Matter Author Keywords: Oxidative Stress Biochemical-indicators Carbon Nanotubes DNA-damage Drugs Immune-reaction Lung Lung-cells Nanoparticles Nanotechnology Oxidation Oxidative-processes Therapeutic-agents

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• ISSN:
  0066-4278
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  447-465
• Volume:
  76
• NIOSHTIC Number:
  nn:20045197
• Citation:
  Annu Rev Physiol 2014 Feb; 76:447-465
• Contact Point Address:
  Amy K. Madl, Center for Health and the Environment, University of California, Davis, California, CA 95616, USA
• Email:
  akmadl@ucdavis.edu
• Federal Fiscal Year:
  2014
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Annual Review of Physiology
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cbf07f2b69a63d17968aec152d24001bf455b769ab6f425773d9dcae45c3eb953085968c2e924d19bd4de4db7db5e90268e8611272ab0e99428773f43aea351c
• Download URL:
  https://stacks.cdc.gov/view/cdc/200710/cdc_200710_DS1.pdf
• File Type:
  [PDF - 1.16 MB ]