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Cardiac R2* values are independent on the image analysis approach employed
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October 01 2013
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Source: Magn Reson Med. 72(2):485-491
[PDF-789.23 KB]
Details:
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Alternative Title:Magn Reson Med
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Personal Author:
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Description:Purpose
To determine whether systematic differences were present between myocardial R2* values obtained with two different decay models: truncation and exponential-plus-constant (Exp-C).
Methods
Single-center cohorts were used to compare black and bright blood sequences separately and a multi-center cohort of mixed bright and black blood studies was used to assess the generalizability. Truncated exponential estimates were calculated with CMRTools that uses a single region of interest (ROI) method. Exp-C estimates were calculated using a pixelwise approach.
Results
No differences could be distinguished based upon whether a white or black blood sequence was examined. The two fitting algorithms gave similar R2* values, with R-squared values exceeding 0.997 and CoV of 3–4%. Results using the pixelwise method yielded a small systematic bias (~3%) that became apparent in patients with severe iron deposition. This disparity disappeared when Exp-C fitting was used on a single ROI suggesting that the use of pixelwise mapping was responsible for the bias. In the multicenter cohort the strong agreement between the two fitting approaches was reconfirmed.
Conclusion
Cardiac R2* values are independent of the signal model used for its calculation over clinically relevant ranges. Clinicians can compare results among centers using these disparate approaches with confidence.
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Source:
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Pubmed ID:24123261
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Pubmed Central ID:PMC4293021
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Funding:
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Volume:72
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Issue:2
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