Cardiac R2* values are independent on the image analysis approach employed
Published Date:Oct 01 2013
Source:Magn Reson Med. 72(2):485-491.
Pubmed Central ID:PMC4293021
Funding:1 R01 HL075592-01A1/HL/NHLBI NIH HHS/United States
1 U01 DD000309-1/DD/NCBDD CDC HHS/United States
M01 RR000043/RR/NCRR NIH HHS/United States
R01 HL075592/HL/NHLBI NIH HHS/United States
RC1 HL099412/HL/NHLBI NIH HHS/United States
RR00043-43/RR/NCRR NIH HHS/United States
To determine whether systematic differences were present between myocardial R2* values obtained with two different decay models: truncation and exponential-plus-constant (Exp-C).
Single-center cohorts were used to compare black and bright blood sequences separately and a multi-center cohort of mixed bright and black blood studies was used to assess the generalizability. Truncated exponential estimates were calculated with CMRTools that uses a single region of interest (ROI) method. Exp-C estimates were calculated using a pixelwise approach.
No differences could be distinguished based upon whether a white or black blood sequence was examined. The two fitting algorithms gave similar R2* values, with R-squared values exceeding 0.997 and CoV of 3–4%. Results using the pixelwise method yielded a small systematic bias (~3%) that became apparent in patients with severe iron deposition. This disparity disappeared when Exp-C fitting was used on a single ROI suggesting that the use of pixelwise mapping was responsible for the bias. In the multicenter cohort the strong agreement between the two fitting approaches was reconfirmed.
Cardiac R2* values are independent of the signal model used for its calculation over clinically relevant ranges. Clinicians can compare results among centers using these disparate approaches with confidence.
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