Cardiac R2* values are independent on the image analysis approach employed

Details

• Alternative Title:
  Magn Reson Med
• Personal Author:
  Meloni, Antonella ; Rienhoff, Hugh Young ; Jones, Amber ; Pepe, Alessia ; Lombardi, Massimo ; Wood, John C.
• Description:
  Purpose
  
  To determine whether systematic differences were present between myocardial R2* values obtained with two different decay models: truncation and exponential-plus-constant (Exp-C).
  
  Methods
  
  Single-center cohorts were used to compare black and bright blood sequences separately and a multi-center cohort of mixed bright and black blood studies was used to assess the generalizability. Truncated exponential estimates were calculated with CMRTools that uses a single region of interest (ROI) method. Exp-C estimates were calculated using a pixelwise approach.
  
  Results
  
  No differences could be distinguished based upon whether a white or black blood sequence was examined. The two fitting algorithms gave similar R2* values, with R-squared values exceeding 0.997 and CoV of 3–4%. Results using the pixelwise method yielded a small systematic bias (~3%) that became apparent in patients with severe iron deposition. This disparity disappeared when Exp-C fitting was used on a single ROI suggesting that the use of pixelwise mapping was responsible for the bias. In the multicenter cohort the strong agreement between the two fitting approaches was reconfirmed.
  
  Conclusion
  
  Cardiac R2* values are independent of the signal model used for its calculation over clinically relevant ranges. Clinicians can compare results among centers using these disparate approaches with confidence.
  
  
• Subjects:
  Algorithms Article Artifacts Beta-Thalassemia Cardiac R2* Cardiovascular Magnetic Resonance Female Heart Diseases Humans Image Analysis Image Interpretation, Computer-Assisted Iron Overload Magnetic Resonance Imaging Male Reproducibility Of Results Sensitivity And Specificity Young Adult

  More +
• Source:
  Magn Reson Med. 72(2):485-491
• Pubmed ID:
  24123261
• Pubmed Central ID:
  PMC4293021
• Document Type:
  Journal Article
• Funding:
  RC1 HL099412/HL/NHLBI NIH HHS/United States ; RR00043-43/RR/NCRR NIH HHS/United States ; 1 U01 DD000309-1/DD/NCBDD CDC HHS/United States ; R01 HL075592/HL/NHLBI NIH HHS/United States ; M01 RR000043/RR/NCRR NIH HHS/United States ; U01 DD000309/DD/NCBDD CDC HHS/United States ; 1 R01 HL075592-01A1/HL/NHLBI NIH HHS/United States
• Volume:
  72
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b708fc1a53367bda2c4b8b9db9da6a0caa01fb37ff134965c3f6e91ed27c55b8
• Download URL:
  https://stacks.cdc.gov/view/cdc/30236/cdc_30236_DS1.pdf
• File Type:
  [PDF - 789.23 KB ]