Cardiac complications in thalassemia throughout the lifespan: Victories and challenges

Details

• Alternative Title:
  Ann N Y Acad Sci
• Personal Author:
  Wood, John C.
• Description:
  Thalassemias are among the most common hereditary diseases in the world because heterozygosity offers protection against malarial infection. Affected individuals have variable expression of alpha or beta chains that lead to their unbalanced utilization during hemoglobin formation, oxidative stress, and apoptosis of red cell precursors prior to maturation. Some individuals produce sufficient hemoglobin to survive but suffer the vascular stress imposed by chronic anemia and ineffective erythropoiesis. In other patients, mature red cell formation is insufficient, and chronic transfusions are required-suppressing anemia and ineffective erythropoiesis but at the expense of iron overload. The cardiovascular consequences of thalassemia have changed dramatically over the previous five decades because of evolving treatment practices. This review summarizes this evolution, focusing on complications and management pertinent to modern patient cohorts.
• Subjects:
  Beta-Thalassemia Erythropoiesis Heart Hemoglobins Humans Iron Overload Longevity Thalassemia
• Keywords:
  Arrhythmias Cardiovascular Health Chelation Heart Failure Iron Overload Pulmonary Hypertension Thalassemia
• Source:
  Ann N Y Acad Sci. 1530(1):64-73
• Pubmed ID:
  37902424
• Pubmed Central ID:
  PMC10841366
• Document Type:
  Journal Article
• Funding:
  1 RO1 HL075592-01A1/HL/NHLBI NIH HHSUnited States/ ; R01 HL075592/HL/NHLBI NIH HHSUnited States/ ; 1R01DK097115-01A1/DK/NIDDK NIH HHSUnited States/ ; 1 U01 DD000309-1/CC/CDC HHSUnited States/ ; R01 DK097115/DK/NIDDK NIH HHSUnited States/ ; M01 RR000043/RR/NCRR NIH HHSUnited States/ ; U01 DD000309/DD/NCBDD CDC HHSUnited States/ ; UL1 TR001855/TR/NCATS NIH HHSUnited States/
• Volume:
  1530
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:6d1776f30abbccc9853c7d3561c1a598395c2a4d6184a9aee04fb0827aadc187f6292b58a22dd5a434c47583e885f334bdb84420a8bba7313537c31d0b4157b7
• Download URL:
  https://stacks.cdc.gov/view/cdc/147708/cdc_147708_DS1.pdf
• File Type:
  [PDF - 399.80 KB ]