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Particle-guided Image Registration
  • Published Date:
  • Source:
    Med Image Comput Comput Assist Interv. 16(0 3):203-210.
Filetype[PDF-442.64 KB]

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  • Pubmed Central ID:
  • Description:
    We present a novel image registration method based on B-spline free-form deformation that simultaneously optimizes particle correspondence and image similarity metrics. Different from previous B-spline based registration methods optimized w.r.t. the control points, the deformation in our method is estimated from a set of dense unstructured pair of points, which we refer as corresponding particles. As intensity values are matched on the corresponding location, the registration performance is iteratively improved. Moreover, the use of corresponding particles naturally extends our method to a group-wise registration by computing a mean of particles. Motivated by a surface-based group-wise particle correspondence method, we developed a novel system that takes such particles to the image domain, while keeping the spirit of the method similar. The core algorithm both minimizes an entropy based group-wise correspondence metric as well as maximizes the space sampling of the particles. We demonstrate the results of our method in an application of rodent brain structure segmentation and show that our method provides better accuracy in two structures compared to other registration methods.

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  • Funding:
    R42 NS059095/NS/NINDS NIH HHS/United States
    U01 AA019969/AA/NIAAA NIH HHS/United States
    A020024/PHS HHS/United States
    AA019969/AA/NIAAA NIH HHS/United States
    U24 AA020022/AA/NIAAA NIH HHS/United States
    R01 AA006059/AA/NIAAA NIH HHS/United States
    P01 DA022446/DA/NIDA NIH HHS/United States
    U54 EB005149/EB/NIBIB NIH HHS/United States
    P30 HD03110/HD/NICHD NIH HHS/United States
    R41 NS059095/NS/NINDS NIH HHS/United States
    U54 sEB005149/SE/SEPDPO CDC HHS/United States
    P30 HD003110/HD/NICHD NIH HHS/United States
    U24 AA020024/AA/NIAAA NIH HHS/United States
    U01 AA020023/AA/NIAAA NIH HHS/United States
    U01 AA020022/AA/NIAAA NIH HHS/United States
    A020023/PHS HHS/United States
    AA06059/AA/NIAAA NIH HHS/United States
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